Search Results - "Fitzsimons, Daniel P."

Cardiac MyBP-C Regulates the Rate and Force of Contraction in Mammalian Myocardium by Moss, Richard L, Fitzsimons, Daniel P, Ralphe, J Carter

“…Cardiac myosin–binding protein-C (cMyBP-C) is a thick filament-associated protein that seems to contribute to the regulation of cardiac contraction through…”
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RLC phosphorylation amplifies Ca2+ sensitivity of force in myocardium from cMyBP-C knockout mice by Turner, Kyrah L, Morris, Haley S, Awinda, Peter O, Fitzsimons, Daniel P, Tanner, Bertrand C W

“…Hypertrophic cardiomyopathy (HCM) is the leading genetic cause of heart disease. The heart comprises several proteins that work together to properly facilitate…”
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Differential roles of regulatory light chain and myosin binding protein‐C phosphorylations in the modulation of cardiac force development by Colson, Brett A., Locher, Matthew R., Bekyarova, Tanya, Patel, Jitandrakumar R., Fitzsimons, Daniel P., Irving, Thomas C., Moss, Richard L.

“…Phosphorylation of myosin regulatory light chain (RLC) by myosin light chain kinase (MLCK) and myosin binding protein‐C (cMyBP‐C) by protein kinase A (PKA)…”
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Phosphorylation of cardiac Myosin-binding protein-C is a critical mediator of diastolic function by Rosas, Paola C, Liu, Yang, Abdalla, Mohamed I, Thomas, Candice M, Kidwell, David T, Dusio, Giuseppina F, Mukhopadhyay, Dhriti, Kumar, Rajesh, Baker, Kenneth M, Mitchell, Brett M, Powers, Patricia A, Fitzsimons, Daniel P, Patel, Bindiya G, Warren, Chad M, Solaro, R John, Moss, Richard L, Tong, Carl W

“…Heart failure (HF) with preserved ejection fraction (HFpEF) accounts for ≈50% of all cases of HF and currently has no effective treatment. Diastolic…”
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Myosin binding protein-C phosphorylation is the principal mediator of protein kinase A effects on thick filament structure in myocardium by Colson, Brett A, Patel, Jitandrakumar R, Chen, Peter P, Bekyarova, Tanya, Abdalla, Mohamed I, Tong, Carl W, Fitzsimons, Daniel P, Irving, Thomas C, Moss, Richard L

“…Abstract Phosphorylation of cardiac myosin binding protein-C (cMyBP-C) is a regulator of pump function in healthy hearts. However, the mechanisms of regulation…”
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Protein Kinase A-Mediated Phosphorylation of cMyBP-C Increases Proximity of Myosin Heads to Actin in Resting Myocardium by Colson, Brett A, Bekyarova, Tanya, Locher, Matthew R, Fitzsimons, Daniel P, Irving, Thomas C, Moss, Richard L

“…Protein kinase A-mediated (PKA) phosphorylation of cardiac myosin binding protein C (cMyBP-C) accelerates the kinetics of cross-bridge cycling and may relieve…”
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Overexpression of TEAD-1 in Transgenic Mouse Striated Muscles Produces a Slower Skeletal Muscle Contractile Phenotype by Tsika, Richard W., Schramm, Christine, Simmer, Gretchen, Fitzsimons, Daniel P., Moss, Richard L., Ji, Juan

“…TEA domain (TEAD) transcription factors serve important functional roles during embryonic development and in striated muscle gene expression. Our previous work…”
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Radial Displacement of Myosin Cross-bridges in Mouse Myocardium due to Ablation of Myosin Binding Protein-C by Colson, Brett A., Bekyarova, Tanya, Fitzsimons, Daniel P., Irving, Thomas C., Moss, Richard L.

“…Myosin binding protein-C (cMyBP-C) is a thick filament accessory protein, which in cardiac muscle functions to regulate the kinetics of cross-bridge…”
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Regulation of contraction in mammalian striated muscles--the plot thick-ens by Moss, Richard L, Fitzsimons, Daniel P

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Destabilization of the dystrophin-glycoprotein complex without functional deficits in alpha-dystrobrevin null muscle by Bunnell, Tina M, Jaeger, Michele A, Fitzsimons, Daniel P, Prins, Kurt W, Ervasti, James M

“…Alpha-dystrobrevin is a component of the dystrophin-glycoprotein complex (DGC) and is thought to have both structural and signaling roles in skeletal muscle…”
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Cardiac MyBP-C phosphorylation regulates the Frank-Starling relationship in murine hearts by Hanft, Laurin M, Fitzsimons, Daniel P, Hacker, Timothy A, Moss, Richard L, McDonald, Kerry S

“…The Frank-Starling relationship establishes that elevated end-diastolic volume progressively increases ventricular pressure and stroke volume in healthy…”
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Transgenic overexpression of γ-cytoplasmic actin protects against eccentric contraction-induced force loss in mdx mice by Baltgalvis, Kristen A, Jaeger, Michele A, Fitzsimons, Daniel P, Thayer, Stanley A, Lowe, Dawn A, Ervasti, James M

“…γ-cytoplasmic (γ-cyto) actin levels are elevated in dystrophin-deficient mdx mouse skeletal muscle. The purpose of this study was to determine whether further…”
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Cooperative mechanisms underlie differences in myocardial contractile dynamics between large and small mammals by Patel, Jitandrakumar R, Park, Kayla J V, Bradshaw, Aidan S, Phan, Tuan, Fitzsimons, Daniel P

“…Ca2+ binding to troponin C (TnC) and myosin cross-bridge binding to actin act in a synergistic cooperative manner to modulate myocardial contraction and…”
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The W792R HCM missense mutation in the C6 domain of cardiac myosin binding protein-C increases contractility in neonatal mouse myocardium by Mertens, Jasmine, De Lange, Willem J., Farrell, Emily T., Harbaugh, Ella C., Gauchan, Angeela, Fitzsimons, Daniel P., Moss, Richard L., Ralphe, J. Carter

“…Missense mutations in cardiac myosin binding protein C (cMyBP-C) are known to cause hypertrophic cardiomyopathy (HCM). The W792R mutation in the C6 domain of…”
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Cross-bridge interaction kinetics in rat myocardium are accelerated by strong binding of myosin to the thin filament by Fitzsimons, Daniel P., Patel, Jitandrakumar R., Moss, Richard L.

“…To determine the ability of strong-binding myosin cross-bridges to activate the myocardial thin filament, we examined the Ca 2+ dependence of force and…”
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Role of myosin heavy chain composition in kinetics of force development and relaxation in rat myocardium by Fitzsimons, Daniel P., Patel, Jitandrakumar R., Moss, Richard L.

“…The effects of ventricular myosin heavy chain (MHC) composition on the kinetics of activation and relaxation were examined in both chemically skinned and…”
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cMyBP-C phosphorylation modulates the time-dependent slowing of unloaded shortening in murine skinned myocardium by Giles, Jasmine, Fitzsimons, Daniel P, Patel, Jitandrakumar R, Knudtsen, Chloe, Neuville, Alexander, Moss, Richard L

“…In myocardium, phosphorylation of cardiac myosin-binding protein-C (cMyBP-C) is thought to modulate the cooperative activation of the thin filament by binding…”
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Deletion of Enigma Homologue from the Z-disc slows tension development kinetics in mouse myocardium by Gregorich, Zachery R, Patel, Jitandrakumar R, Cai, Wenxuan, Lin, Ziqing, Heurer, Rachel, Fitzsimons, Daniel P, Moss, Richard L, Ge, Ying

“…Enigma Homologue (ENH) is a component of the Z-disc, a structure that anchors actin filaments in the contractile unit of muscle, the sarcomere…”
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Ablation of Myosin-Binding Protein-C Accelerates Force Development in Mouse Myocardium by Stelzer, Julian E., Fitzsimons, Daniel P., Moss, Richard L.

“…Myosin-binding protein-C (MyBP-C) is a thick filament-associated protein that binds tightly to myosin. Given that cMyBP-C may act to modulate cooperative…”
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Acting on an impulse (or two): Advantages of high-frequency tetanic onset in skeletal muscle by Moss, Richard L, Lynch, 4th, Thomas L, Fitzsimons, Daniel P

“…Moss et al. highlight why high-frequency bursts at the onset of tetany increase force development in fast-twitch skeletal muscle fibers…”
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