Search Results - "Fitzsimmons, Colin"

Protective human IgE responses are promoted by comparable life-cycle dependent Tegument Allergen-Like expression in Schistosoma haematobium and Schistosoma mansoni infection by Oettle, Rebecca C, Dickinson, Harriet A, Fitzsimmons, Colin M, Sacko, Moussa, Tukahebwa, Edridah M, Chalmers, Iain W, Wilson, Shona

“…Schistosoma haematobium is the most prevalent of the human-infecting schistosome species, causing significant morbidity in endemically exposed populations…”
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Comparisons of Allergenic and Metazoan Parasite Proteins: Allergy the Price of Immunity by Tyagi, Nidhi, Farnell, Edward J, Fitzsimmons, Colin M, Ryan, Stephanie, Tukahebwa, Edridah, Maizels, Rick M, Dunne, David W, Thornton, Janet M, Furnham, Nicholas

“…Allergic reactions can be considered as maladaptive IgE immune responses towards environmental antigens. Intriguingly, these mechanisms are observed to be very…”
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Omega-1, a glycoprotein secreted by Schistosoma mansoni eggs, drives Th2 responses by Everts, Bart, Perona-Wright, Georgia, Smits, Hermelijn H, Hokke, Cornelis H, van der Ham, Alwin J, Fitzsimmons, Colin M, Doenhoff, Michael J, van der Bosch, Jürgen, Mohrs, Katja, Haas, Helmut, Mohrs, Markus, Yazdanbakhsh, Maria, Schramm, Gabriele

“…Soluble egg antigens of the parasitic helminth Schistosoma mansoni (S. mansoni egg antigen [SEA]) induce strong Th2 responses both in vitro and in vivo…”
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Comparative biochemical analysis of three members of the Schistosoma mansoni TAL family: Differences in ion and drug binding properties by Thomas, Charlotte M., Fitzsimmons, Colin M., Dunne, David W., Timson, David J.

“…The tegumental allergen-like (TAL) proteins from Schistosoma mansoni are part of a family of calcium binding proteins found only in parasitic flatworms. These…”
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Survival of the fittest: allergology or parasitology? by Fitzsimmons, Colin M, Dunne, David W

“…Allergologists have long recognized that only a small fraction of the environmental and food proteins that we are exposed to give rise to IgE responses. This…”
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Influence of exposure history on the immunology and development of resistance to human Schistosomiasis mansoni by Black, Carla L, Mwinzi, Pauline N M, Muok, Erick M O, Abudho, Bernard, Fitzsimmons, Colin M, Dunne, David W, Karanja, Diana M S, Secor, W Evan, Colley, Daniel G

“…Previous studies suggest that humans can acquire immunity to reinfection with schistosomes, most probably due to immunologic mechanisms acquired after exposure…”
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Progressive Cross-Reactivity in IgE Responses: an Explanation for the Slow Development of Human Immunity to Schistosomiasis? by FITZSIMMONS, Colin M, JONES, Frances M, DE MOIRA, Angela Pinot, PROTASIO, Anna V, KHALIFE, Jamal, DICKINSON, Harriet A, TUKAHEBWA, Edridah M, DUNNE, David W

“…OA  Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Human Schistosoma haematobium Antifecundity Immunity Is Dependent on Transmission Intensity and Associated With Immunoglobulin G1 to Worm-Derived Antigens by Wilson, Shona, Jones, Frances M., van Dam, Govert J., Corstjens, Paul L. A. M., Riveau, Gilles, Fitzsimmons, Colin M., Sacko, Moussa, Vennervald, Birgitte J., Dunne, David W.

“…Background. Immunity that reduces worm fecundity and, in turn, reduces morbidity is proposed for Schistosoma haematobium, a parasite of major public health…”
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Use of humanised rat basophilic leukaemia cell line RS-ATL8 for the assessment of allergenicity of Schistosoma mansoni proteins by Wan, Daniel, Ludolf, Fernanda, Alanine, Daniel G W, Stretton, Owen, Ali Ali, Eman, Al-Barwary, Nafal, Wang, Xiaowei, Doenhoff, Michael J, Mari, Adriano, Fitzsimmons, Colin M, Dunne, David W, Nakamura, Ryosuke, Oliveira, Guilherme C, Alcocer, Marcos J C, Falcone, Franco H

“…Parasite-specific IgE is thought to correlate with protection against Schistosoma mansoni infection or re-infection. Only a few molecular targets of the IgE…”
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Helminth Allergens, Parasite-Specific IgE, and Its Protective Role in Human Immunity by Fitzsimmons, Colin Matthew, Falcone, Franco Harald, Dunne, David William

“…The Th2 immune response, culminating in eosinophilia and IgE production, is not only characteristic of allergy but also of infection by parasitic worms…”
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Effects of Treatment on IgE Responses against Parasite Allergen-Like Proteins and Immunity to Reinfection in Childhood Schistosome and Hookworm Coinfections by Pinot de Moira, Angela, Jones, Frances M, Wilson, Shona, Tukahebwa, Edridah, Fitzsimmons, Colin M, Mwatha, Joseph K, Bethony, Jeffrey M, Kabatereine, Narcis B, Dunne, David W

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Maternal hookworm modifies risk factors for childhood eczema: results from a birth cohort in Uganda by Mpairwe, Harriet, Ndibazza, Juliet, Webb, Emily L., Nampijja, Margaret, Muhangi, Lawrence, Apule, Barbara, Lule, Swaib, Akurut, Hellen, Kizito, Dennison, Kakande, Mohammed, Jones, Frances M., Fitzsimmons, Colin M., Muwanga, Moses, Rodrigues, Laura C., Dunne, David W., Elliott, Alison M.

“…Background Worms may protect against allergy. Early‐life worm exposure may be critical, but this has not been fully investigated. Objectives To investigate…”
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Human IgG1 Responses to Surface Localised Schistosoma mansoni Ly6 Family Members Drop following Praziquantel Treatment by Chalmers, Iain W, Fitzsimmons, Colin M, Brown, Martha, Pierrot, Christine, Jones, Frances M, Wawrzyniak, Jakub M, Fernandez-Fuentes, Narcis, Tukahebwa, Edridah M, Dunne, David W, Khalife, Jamal, Hoffmann, Karl F

“…The heptalaminate-covered, syncytial tegument is an important anatomical adaptation that enables schistosome parasites to maintain long-term, intravascular…”
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Known Allergen Structures Predict Schistosoma mansoni IgE-Binding Antigens in Human Infection by Farnell, Edward J, Tyagi, Nidhi, Ryan, Stephanie, Chalmers, Iain W, Pinot de Moira, Angela, Jones, Frances M, Wawrzyniak, Jakub, Fitzsimmons, Colin M, Tukahebwa, Edridah M, Furnham, Nicholas, Maizels, Rick M, Dunne, David W

“…The IgE response has been associated with both allergic reactions and immunity to metazoan parasites. Recently, we hypothesized that all environmental…”
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Human IgE responses to different splice variants of Schistosoma mansoni tropomyosin: associations with immunity by Silas, Sukrit, Fitzsimmons, Colin M., Jones, Frances M., Pinot de Moira, Angela, Wawrzyniak, Jakub, Tukahebwa, Edridah M., Dunne, David W.

“…[Display omitted] •Tropomyosin (Tpm) is a common IgE antigen in invertebrates.•Alternative splicing generates at least 13 Tpm isoforms in Schistosoma…”
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The Schistosoma mansoni tegumental-allergen-like (TAL) protein family: influence of developmental expression on human IgE responses by Fitzsimmons, Colin M, Jones, Frances M, Stearn, Alex, Chalmers, Iain W, Hoffmann, Karl F, Wawrzyniak, Jakub, Wilson, Shona, Kabatereine, Narcis B, Dunne, David W

“…A human IgE response to Sm22.6 (a dominant IgE target in Schistosoma mansoni) is associated with the development of partial immunity. Located inside the…”
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Suppression of Basophil Histamine Release and Other IgE-dependent Responses in Childhood Schistosoma mansoni/hookworm Coinfection by de Moira, Angela Pinot, Fitzsimmons, Colin M., Jones, Frances M., Wilson, Shona, Cahen, Pierre, Tukahebwa, Edridah, Mpairwe, Harriet, Mwatha, Joseph K., Bethony, Jeffrey M., Skov, Per S., Kabatereine, Narcis B., Dunne, David W.

“…Background. The poor correlation between allergen-specific immunoglobulin E (asIgE) and clinical signs of allergy in helminth infected populations suggests…”
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Schistosoma mansoni Infection in Preschool-Aged Children: Development of Immunoglobulin E and Immunoglobulin G₄ Responses to Parasite Allergen-Like Proteins by de Moira, Angela Pinot, Sousa-Figueiredo, Jose C., Jones, Frances M., Fitzsimmons, Colin M., Betson, Martha, Kabatereine, Narcis B., Stothard, J. Russell, Dunne, David W.

“…Specific immunoglobulin E (IgE) responses are upregulated during chronic schistosome infection and during allergy. These responses are tightly regulated during…”
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Molecular characterization of omega-1: A hepatotoxic ribonuclease from Schistosoma mansoni eggs by Fitzsimmons, Colin M., Schramm, Gabriele, Jones, Frances M., Chalmers, Iain W., Hoffmann, Karl F., Grevelding, Christoph G., Wuhrer, Manfred, Hokke, Cornelis H., Haas, Helmut, Doenhoff, Michael J., Dunne, David W.

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Factors affecting human IgE and IgG responses to allergen-like Schistosoma mansoni antigens: Molecular structure and patterns of in vivo exposure by Fitzsimmons, Colin M, McBeath, Rowena, Joseph, Sarah, Jones, Frances M, Walter, Klaudia, Hoffmann, Karl F, Kariuki, H Curtis, Mwatha, Joseph K, Kimani, Guchuhi, Kabatereine, Narcis B, Vennervald, Birgitte J, Ouma, John H, Dunne, David W

“…The human IgE response is associated with allergy and with host defence against parasitic worms. A response to Sm22.6, the dominant IgE antigen in adult…”
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