Search Results - "Fitzhugh, David J."

G Protein Coupled Receptor Kinase 3 Regulates Breast Cancer Migration, Invasion, and Metastasis by Billard, Matthew J, Fitzhugh, David J, Parker, Joel S, Brozowski, Jaime M, McGinnis, Marcus W, Timoshchenko, Roman G, Serafin, D Stephen, Lininger, Ruth, Klauber-Demore, Nancy, Sahagian, Gary, Truong, Young K, Sassano, Maria F, Serody, Jonathan S, Tarrant, Teresa K

“…Triple negative breast cancer (TNBC) is a heterogeneous disease that has a poor prognosis and limited treatment options. Chemokine receptor interactions are…”
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Should Epinephrine Autoinjectors Be Prescribed to All Patients on Subcutaneous Immunotherapy? by Fitzhugh, David J., MD, Bernstein, David I., MD

“…Subcutaneous allergen immunotherapy (SCIT) clearly benefits appropriately selected patients with allergic rhinitis, asthma and anaphylaxis to stinging insects…”
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Increasing cost of epinephrine autoinjectors by Westermann-Clark, Emma, MD, MA, Fitzhugh, David J., MD, Lockey, Richard F., MD, MS

“…The average wholesale price of 1 epinephrine autoinjector was found to have increased annually from $35.59 in 1986 to $87.92 in 2011 (147%) in constant 2011 US…”
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History of Immunotherapy: The First 100 Years by Fitzhugh, David J., MD, Lockey, Richard F., MD

“…Allergen-specific immunotherapy (SIT) defines and distinguishes the modern practice of clinical allergy and immunology as the 100th anniversary of this…”
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Bromelain treatment decreases neutrophil migration to sites of inflammation by Fitzhugh, David J, Shan, Siqing, Dewhirst, Mark W, Hale, Laura P

“…Abstract Bromelain, a mixture of proteases derived from pineapple stem, has been reported to have therapeutic benefits in a variety of inflammatory diseases,…”
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Decreased Th17 and antigen-specific humoral responses in CX3CR1-deficient mice in the collagen-induced arthritis model by Tarrant, Teresa K., Liu, Peng, Rampersad, Rishi R., Esserman, Denise, Rothlein, Lisa R., Timoshchenko, Roman G., McGinnis, Marcus W., Fitzhugh, David J., Patel, Dhavalkumar D., Fong, Alan M.

“…Objective CX3CR1 is a chemokine receptor that uniquely binds to its ligand fractalkine (CX3CL1) and has been shown to be important in inflammatory arthritis…”
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Allergen immunotherapy: a history of the first 100 years by Fitzhugh, David J, Lockey, Richard F

“…PURPOSE OF REVIEWTo provide a historical perspective on the development of allergen immunotherapy and to describe the progress that has been made in both the…”
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Functional Characterization of A Cis-Acting Temperature Sensitive Mutation From A Respiratory Syncytial Virus Vaccine Candidate by Teng, Michael, Fitzhugh, David J., MD, Tran, Kim, Lockey, Richard F., MD, Collins, Peter

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Risk factors for reactions and adverse effects during oral immunotherapy by Fitzhugh, David J.

“…Oral immunotherapy (OIT) involves the potential for a variety of adverse events, which range from serious systemic reactions that require epinephrine to…”
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Oral immunogenicity of the plant proteinase bromelain by Hale, Laura P., Fitzhugh, David J., Staats, Herman F.

“…Bromelain is a natural mixture of proteolytic enzymes derived from pineapple stem that has been shown to have anti-inflammatory activity when administered…”
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Cutting Edge: C-C Chemokine Receptor 6 Is Essential for Arrest of a Subset of Memory T Cells on Activated Dermal Microvascular Endothelial Cells Under Physiologic Flow Conditions In Vitro by Fitzhugh, David J, Naik, Shubhada, Caughman, S. Wright, Hwang, Sam T

“…Memory T cells (mTC) express multiple chemokine receptors (including CCR4 and CCR6) that may potentially be involved in their arrest on inflamed endothelia…”
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Fractalkine, a CX3C chemokine, is expressed by dendritic cells and is up‐regulated upon dendritic cell maturation by Papadopoulos, Elektra J., Sassetti, Chris, Saeki, Hidehisa, Yamada, Nobuo, Kawamura, Tatsuyoshi, Fitzhugh, David J., Saraf, Manisha A., Schall, Thomas, Blauvelt, Andrew, Rosen, Steven D., Hwang, Sam T.

“…The lone CX3C chemokine, fractalkine (FK), is expressed in a membrane‐bound form on activated endothelial cells and mediates attachment and firm adhesion of T…”
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The Topoisomerase-related Function Gene TRF4 Affects Cellular Sensitivity to the Antitumor Agent Camptothecin by Walowsky, Carrie, Fitzhugh, David J., Castaño, Irene B., Ju, Justina Y., Levin, Nikki A., Christman, Michael F.

“…Camptothecin is an antitumor agent that kills cells by converting DNA topoisomerase I into a DNA-damaging poison. Although camptothecin derivatives are now…”
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Aberrant Expression of Adhesion Molecules by Sézary Cells: Functional Consequences Under Physiologic Shear Stress Conditions by Hwang, Sam T., Fitzhugh, David J.

“…Although aberrations in adhesion molecule expression by lymphoma cells have been reported, the functional consequences of these changes are unclear. Herein, we…”
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Reaching for best practices in food oral immunotherapy: Report on the second annual Food Allergy Support Team meeting by Wasserman, Richard L, Jones, Douglas H, Windom, Hugh H

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Reaching for best practices in food oral immunotherapy by Wasserman, Richard L., Jones, Douglas H., Windom, Hugh H., Bajowala, Sakina S., Carr, Warner W., Chacko, Thomas, Detjen, Paul F., Fergeson, Jennifer, Fitzhugh, David J., Hague, Angela R., Ly, Jean, Mayer, Chad W., Pence, Deanna M., Shah, Atul N.

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History of Immunotherapy: The First 100 Years: Allergen Immunotherapy by FITZHUGH, David J, LOCKEY, Richard F

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Mast cells migrate, but do not degranulate, in response to fractalkine, a membrane‐bound chemokine expressed constitutively in diverse cells of the skin by Papadopoulos, Elektra J., Fitzhugh, David J., Tkaczyk, Christine, Gilfillan, Alasdair M., Sassetti, Christopher, Metcalfe, Dean D., Hwang, Sam T.

“…Mast cells (MC) are anatomically located near nerves and blood vessels in skin and the gastrointestinal tract and tend to localize within certain cutaneous…”
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A Novel Family of TRF (DNA Topoisomerase I-Related Function) Genes Required for Proper Nuclear Segregation by Castaño, Irene B., Heath-Pagliuso, Sharon, Sadoff, Ben U., Fitzhugh, David J., Christman, Michael F.

“…We recently reported the identification of a gene, TRF4 (for DNA topoisomerase related function), in a screen for mutations that are synthetically lethal with…”
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Engagement of the T lymphocyte antigen receptor regulates association of son‐of‐sevenless homologues with the SH3 domain of phospholipase Cγ1 by Scholler, John K., Perez‐Villar, Juan J., O'Day, Kathleen, Kanner, Steven B.

“…One mechanism for transducing signals downstream of lymphocyte receptor activation involves the stable association between signaling proteins. To identify…”
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