Search Results - "Fitzgibbon, Matthew J"

X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex by Griffith, James P, Kim, Joseph L, Kim, Eunice E, Sintchak, Michael D, Thomson, John A, Fitzgibbon, Matthew J, Fleming, Mark A, Caron, Paul R, Hsiao, Kathy, Navia, Manuel A

“…The X-ray structure of the ternary complex of a calcineurin A fragment, calcineurin B, FKBP12, and the immunosuppressant drug FK506 (also known as tacrolimus)…”
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Structure of Mitogen-activated Protein Kinase-activated Protein (MAPKAP) Kinase 2 Suggests a Bifunctional Switch That Couples Kinase Activation with Nuclear Export by Meng, Wuyi, Swenson, Lora L., Fitzgibbon, Matthew J., Hayakawa, Koto, ter Haar, Ernst, Behrens, Anne E., Fulghum, John R., Lippke, Judith A.

“…MAPK-activated protein kinase 2 (MAPKAPK2), one of several kinases directly phosphorylated and activated by p38 MAPK, plays a central role in the inflammatory…”
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Solution structure of the major binding protein for the immunosuppressant FK506 by Moore, Jonathan M, Peattie, Debra A, Fitzgibbon, Matthew J, Thomson, John A

“…The major FK506 binding protein (FKBP, relative molecular mass approximately 11,800; Mr 11.8K) and cyclophilin (Mr approximately 17K) belong to a class of…”
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The structure of phosphorylated P38γ is monomeric and reveals a conserved activation-loop conformation by Bellon, Steve, Fitzgibbon, Matthew J, Fox, Ted, Hsiao, Hsun-Mei, Wilson, Keith P

“…Background: Mitogen-activated protein (MAP) kinases mediate the cellular response to stimuli such as pro-inflammatory cytokines and environmental stress. P38 γ…”
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Crystal Structure of p38 Mitogen-activated Protein Kinase by Wilson, Keith P., Fitzgibbon, Matthew J., Caron, Paul R., Griffith, James P., Chen, Wenyong, McCaffrey, Patricia G., Chambers, Stephen P., Su, Michael S.-S.

“…p38 mitogen-activated protein kinase is activated by environmental stress and cytokines and plays a role in transcriptional regulation and inflammatory…”
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Kinetic Mechanism of the p38-α MAP Kinase:  Phosphoryl Transfer to Synthetic Peptides by Chen, Guanjing, Porter, Margaret D, Bristol, John R, Fitzgibbon, Matthew J, Pazhanisamy, S

“…p38 is a member of the mitogen-activated protein (MAP) kinase family. Activation (phosphorylation) of p38 acts as a switch for the transcriptional and…”
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Kinetic mechanism and ATP-binding site reactivity of p38γ MAP kinase by Fox, Ted, Fitzgibbon, Matthew J, Fleming, Mark A, Hsiao, Hsun-Mei, Brummel, Christopher L, Su, Michael S-S

“…Activated p38γ MAP kinase exhibited significant basal ATPase activity in the absence of a kinase substrate, and addition of a phosphoacceptor substrate…”
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Probing hydration contributions to the thermodynamics of ligand binding by proteins. Enthalpy and heat capacity changes of tacrolimus and rapamycin binding to FK506 binding protein in deuterium oxide and water by Connelly, Patrick R, Thomson, John A, Fitzgibbon, Matthew J, Bruzzese, Frank J

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The structural basis for the specificity of pyridinylimidazole inhibitors of p38 MAP kinase by Wilson, Keith P., McCaffrey, Patricia G., Hsiao, Kathy, Pazhanisamy, Sam, Galullo, Vincent, Bemis, Guy W., Fitzgibbon, Matthew J., Caron, Paul R., Murcko, Mark A., Su, Michael S.S.

“…Background: The p38 mitogen-activated protein (MAP) kinase regulates signal transduction in response to environmental stress. Pyridinylimidazole compounds are…”
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Enthalpy of Hydrogen Bond Formation in a Protein-Ligand Binding Reaction by Connelly, Patrick R., Aldape, Robert A., Bruzzese, Frank J., Chambers, Stephen P., Fitzgibbon, Matthew J., Fleming, Mark A., Itoh, Susumu, Livingston, David J., Navia, manuel A., Thomson, John A., Wilson, Keith P.

“…Parallel measurements of the thermodynamics (free-energy, enthalpy, entropy and heat-capacity changes) of ligand binding to FK506 binding protein (FKBP-12) in…”
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Probing hydration contributions to the thermodynamics of ligand binding by proteins. Enthalpy and heat capacity changes of tacrolimus and rapamycin binding to FK506 binding protein in D2O and H2O by CONNELLY, P. R, THOMSON, J. A, FITZGIBBON, M. J, BRUZZESE, F. J

“…The stabilities of native proteins and protein-ligand complexes result from differential interactions among numerous polar and nonpolar atoms within the…”
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Preliminary analysis of multiple crystal forms of the bovine cyclophilin-cyclosporin A complex by Itoh, S, Fitzgibbon, M J, Black, J R, Navia, M A

“…The immunosuppressant cyclosporin-A (CsA) has been crystallized in complex with the bovine form of its major receptor protein cyclophilin (CyP) in three…”
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