Search Results - "Fitzgerald, R C"

scRNA-seq assessment of the human lung, spleen, and esophagus tissue stability after cold preservation by Madissoon, E, Wilbrey-Clark, A, Miragaia, R J, Saeb-Parsy, K, Mahbubani, K T, Georgakopoulos, N, Harding, P, Polanski, K, Huang, N, Nowicki-Osuch, K, Fitzgerald, R C, Loudon, K W, Ferdinand, J R, Clatworthy, M R, Tsingene, A, van Dongen, S, Dabrowska, M, Patel, M, Stubbington, M J T, Teichmann, S A, Stegle, O, Meyer, K B

“…The Human Cell Atlas is a large international collaborative effort to map all cell types of the human body. Single-cell RNA sequencing can generate…”
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Molecular basis of Barrett’s oesophagus and oesophageal adenocarcinoma by Fitzgerald, R C

“…The rationale for the use of acid suppression arises from the in vitro and ex vivo data discussed above, which suggest that acid may adversely affect cell…”
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Early diagnosis of oesophageal cancer by Bird-Lieberman, E L, Fitzgerald, R C

“…Squamous cell carcinoma and adenocarcinoma of the oesophagus are cancers that develop from distinct epithelial sub-types; however, they are both related to…”
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Multi-omic cross-sectional cohort study of pre-malignant Barrett’s esophagus reveals early structural variation and retrotransposon activity by Katz-Summercorn, A. C., Jammula, S., Frangou, A., Peneva, I., O’Donovan, M., Tripathi, M., Malhotra, S., di Pietro, M., Abbas, S., Devonshire, G., Januszewicz, W., Blasko, A., Nowicki-Osuch, K., MacRae, S., Northrop, A., Redmond, A. M., Wedge, D. C., Fitzgerald, R. C.

“…Barrett’s esophagus is a pre-malignant lesion that can progress to esophageal adenocarcinoma. We perform a multi-omic analysis of pre-cancer samples from 146…”
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Histopathological and molecular analysis of gastrectomy specimens from hereditary diffuse gastric cancer patients has implications for endoscopic surveillance of individuals at risk by Barber, ME, Save, V, Carneiro, F, Dwerryhouse, S, Lao-Sirieix, P, Hardwick, RH, Caldas, C, Fitzgerald, RC

“…Hereditary diffuse gastric cancer (HDGC) is caused by germline E-cadherin (CDH1) mutations in 25-40% of tested families. Management options for asymptomatic…”
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Mechanisms and sequelae of E-cadherin silencing in hereditary diffuse gastric cancer by Barber, M, Murrell, A, Ito, Y, Maia, A.T, Hyland, S, Oliveira, C, Save, V, Carneiro, F, Paterson, AL, Grehan, N, Dwerryhouse, S, Lao-Sirieix, P, Caldas, C, Fitzgerald, RC

“…Around 25-40% of cases of hereditary diffuse gastric cancer (HDGC) are caused by heterozygous E-cadherin (CDH1) germline mutations. The mechanisms for loss of…”
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Non-endoscopic screening biomarkers for Barrett's oesophagus: from microarray analysis to the clinic by Lao-Sirieix, P, Boussioutas, A, Kadri, S R, O'Donovan, M, Debiram, I, Das, M, Harihar, L, Fitzgerald, R C

“…Barrett's oesophagus predisposes to oesophageal adenocarcinoma but the majority of patients are undiagnosed. A novel non-endoscopic cytological screening…”
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Pilot study of cytological testing for oesophageal squamous cell dysplasia in a high-risk area in Northern Iran by Roshandel, G, Merat, S, Sotoudeh, M, Khoshnia, M, Poustchi, H, Lao-Sirieix, P, Malhotra, S, O'Donovan, M, Etemadi, A, Nickmanesh, A, Pourshams, A, Norouzi, A, Debiram, I, Semnani, S, Abnet, C C, Dawsey, S M, Fitzgerald, R C, Malekzadeh, R

“…Background: Oesophageal squamous cell carcinoma (ESCC) is a fatal disease with 5-year survival rates of <5% in Northern Iran. Oesophageal squamous dysplasia…”
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Clinical implications of E-cadherin associated hereditary diffuse gastric cancer by Fitzgerald, R C, Caldas, C

“…Approximately 1–3% of gastric cancers arise as a result of inherited gastric cancer predisposition syndromes. These may be of the diffuse or intestinal type…”
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Barrett’s oesophagus and oesophageal adenocarcinoma: how does acid interfere with cell proliferation and differentiation? by Fitzgerald, R C

“…Acid, a principal component of gastro-oesophageal refluxate, may contribute to the development and malignant progression of Barrett’s oesophagus. Oesophageal…”
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Integrative analysis of array-comparative genomic hybridisation and matched gene expression profiling data reveals novel genes with prognostic significance in oesophageal adenocarcinoma by Goh, X Y, Rees, J R E, Paterson, A L, Chin, S F, Marioni, J C, Save, V, O'Donovan, M, Eijk, P P, Alderson, D, Ylstra, B, Caldas, C, Fitzgerald, R C

“…The incidence of oesophageal adenocarcinoma (OAC) has been increasing rapidly with a dismal survival rate of less than 20%. Understanding the genomic…”
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Differentiation and proliferation in Barrett's esophagus and the effects of acid suppression by Ouatu–Lascar, Rodica, Fitzgerald, Rebecca C., Triadafilopoulos, George

“…Background & Aims: Maintenance of normal epithelial differentiation and proliferation is an important goal in cancer chemoprevention. Because acid has a…”
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Diversity in the oesophageal phenotypic response to gastro-oesophageal reflux: immunological determinants by Fitzgerald, R C, Onwuegbusi, B A, Bajaj-Elliott, M, Saeed, I T, Burnham, W R, Farthing, M J G

“…Background and aims: Approximately 10% of adults experience gastro-oesophageal reflux symptoms with a variable oesophageal response. A total of 60% have no…”
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Inflammatory gradient in Barrett’s oesophagus: implications for disease complications by Fitzgerald, R C, Abdalla, S, Onwuegbusi, B A, Sirieix, P, Saeed, I T, Burnham, W R, Farthing, M J G

“…Introduction: Barrett’s oesophageal epithelium (BE) is clinically important due to the associated inflammatory and malignant complications which are unevenly…”
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Dynamic effects of acid on Barrett's esophagus. An ex vivo proliferation and differentiation model by Fitzgerald, R C, Omary, M B, Triadafilopoulos, G

“…Barrett's esophagus (BE), or specialized intestinal metaplasia, is a premalignant heterogeneous epithelium associated with reflux and an increased risk for…”
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Generation and validation of a revised classification for oesophageal and junctional adenocarcinoma by Peters, C. J., Hardwick, R. H., Vowler, S. L., Fitzgerald, R. C.

“…Background: Oesophageal adenocarcinoma is the commonest oesophageal malignancy in the West, but is staged using a system designed for squamous cell carcinoma…”
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A novel role for the retinoic acid-catabolizing enzyme CYP26A1 in Barrett's associated adenocarcinoma by Chang, C-L, Hong, E, Lao-Sirieix, P, Fitzgerald, R C

“…Vitamin A deficiency is associated with carcinogenesis, and upregulation of CYP26A1, a major retinoic acid (RA)-catabolizing enzyme, has recently been shown in…”
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Endoscopic TriModal imaging and biomarkers for neoplasia conjoined: a feasibility study in Barrett's esophagus by Boerwinkel, D. F., Di Pietro, M., Liu, X., Shariff, M. K., Lao-Sirieix, P., Walker, C. E., Visser, M., O' Donovan, M., Kaye, P., Bergman, J. J. G. H. M., Fitzgerald, R C.

“…Summary In Barrett's esophagus (BE), the normal squamous lining of the esophagus is replaced by specialized columnar epithelium. Endoscopic surveillance with…”
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Systematic review: the application of molecular pathogenesis to prevention and treatment of oesophageal adenocarcinoma by PETERS, C. J., FITZGERALD, R. C.

“…Summary Background Oesophageal adenocarcinoma is an increasingly common cancer with a poor prognosis. It develops in a stepwise progression from Barrett’s…”
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Impaired transforming growth factor β signalling in Barrett’s carcinogenesis due to frequent SMAD4 inactivation by Onwuegbusi, B A, Aitchison, A, Chin, S-F, Kranjac, T, Mills, I, Huang, Y, Lao-Sirieix, P, Caldas, C, Fitzgerald, R C

“…Background and aims: Transforming growth factor β (TGF-β) is frequently involved in gastrointestinal carcinogenesis although its contribution to oesophageal…”
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