Search Results - "Fitzgerald, Laura R"

Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1 by Chambers, Jon, Ames, Robert S, Bergsma, Derk, Muir, Alison, Fitzgerald, Laura R, Hervieu, Guillaume, Dytko, George M, Foley, James J, Martin, John, Liu, Wu-Schyong, Park, Janet, Ellis, Catherine, Ganguly, Subinay, Konchar, Susan, Cluderay, Jane, Leslie, Ron, Wilson, Shelagh, Sarau, Henry M

“…The underlying causes of obesity are poorly understood but probably involve complex interactions between many neurotransmitter and neuropeptide systems…”
Get full text

Novel Mechanistic Class of Fatty Acid Amide Hydrolase Inhibitors with Remarkable Selectivity by Ahn, Kyunghye, Johnson, Douglas S, Fitzgerald, Laura R, Liimatta, Marya, Arendse, Andrea, Stevenson, Tracy, Lund, Eric. T, Nugent, Richard A, Nomanbhoy, Tyzoon K, Alexander, Jessica P, Cravatt, Benjamin F

“…Fatty acid amide hydrolase (FAAH) is an integral membrane enzyme that degrades the fatty acid amide family of signaling lipids, including the endocannabinoid…”
Get full text

Cloning, expression, and pharmacological characterization of a novel human histamine receptor by Zhu, Y, Michalovich, D, Wu, H, Tan, K B, Dytko, G M, Mannan, I J, Boyce, R, Alston, J, Tierney, L A, Li, X, Herrity, N C, Vawter, L, Sarau, H M, Ames, R S, Davenport, C M, Hieble, J P, Wilson, S, Bergsma, D J, Fitzgerald, L R

“…Using a genomics-based reverse pharmacological approach for screening orphan G-protein coupled receptors, we have identified and cloned a novel high-affinity…”
Get more information

Receptor for the Pain Modulatory Neuropeptides FF and AF Is an Orphan G Protein-coupled Receptor by Elshourbagy, N A, Ames, R S, Fitzgerald, L R, Foley, J J, Chambers, J K, Szekeres, P G, Evans, N A, Schmidt, D B, Buckley, P T, Dytko, G M, Murdock, P R, Milligan, G, Groarke, D A, Tan, K B, Shabon, U, Nuthulaganti, P, Wang, D Y, Wilson, S, Bergsma, D J, Sarau, H M

“…Opiate tolerance and dependence are major clinical and social problems. The anti-opiate neuropeptides FF and AF (NPFF and NPAF) have been implicated in pain…”
Get full text

Smoothened antagonists for hair inhibition by Li, Jie Jack, Shanmugasundaram, Veerabahu, Reddy, Satya, Fleischer, Laura L., Wang, Zenquan, Smith, Yvonne, Harter, William G., Yue, Wen-Song, Swaroop, Manju, Li, Ling, Ji, Christy Xiaodong, Dettling, Danielle, Osak, Bella, Fitzgerald, Laura R., Conradi, Robert

“…A series of aminomethylpyrazoles were prepared and evaluated using cell-based Smoothened β-lactamase reporter assay and Smoothened binding assay. Potent…”
Get full text

Neuromedin U Is a Potent Agonist at the Orphan G Protein-coupled Receptor FM3 by Szekeres, Philip G., Muir, Alison I., Spinage, Lisa D., Miller, Jane E., Butler, Sharon I., Smith, Angela, Rennie, Gillian I., Murdock, Paul R., Fitzgerald, Laura R., Wu, Hsiao-ling, McMillan, Lynette J., Guerrera, Stephanie, Vawter, Lisa, Elshourbagy, Nabil A., Mooney, Jeffrey L., Bergsma, Derk J., Wilson, Shelagh, Chambers, Jon K.

“…Neuromedins are a family of peptides best known for their contractile activity on smooth muscle preparations. The biological mechanism of action of neuromedin…”
Get full text

A cluster of novel serotonin receptor 3-like genes on human chromosome 3 by Karnovsky, Alla M., Gotow, Lisa F., McKinley, Denise D., Piechan, Julie L., Ruble, Cara L., Mills, Cynthia J., Schellin, Kathleen A.B., Slightom, Jerry L., Fitzgerald, Laura R., Benjamin, Christopher W., Roberds, Steven L.

“…The ligand-gated ion channel family includes receptors for serotonin (5-hydroxytryptamine, 5-HT), acetylcholine, GABA, and glutamate. Drugs targeting subtypes…”
Get full text

A beta-lactamase reporter assay for monitoring the activation of the smoothened pathway by Osak, Bella, Fitzgerald, Laura R

“…The seven-transmembrane protein Smoothened (Smo) mediates the cellular response to the Hedgehog protein signal and is involved in cell growth and…”
Get more information

Melatonin Agonists for the Treatment of Sleep Disorders and Major Depression by Fitzgerald, Laura R., Reed, Jessica E.

“…Melatonin is widely used as an over-the-counter therapy for the treatment of sleep disorders. This chapter discusses the use of melatonin and synthetic…”
Get full text