Search Results - "Fitzgerald, Hannah"

Regulation of inflammation by the antioxidant haem oxygenase 1 by Campbell, Nicole K., Fitzgerald, Hannah K., Dunne, Aisling

“…Haem oxygenase 1 (HO-1), an inducible enzyme responsible for the breakdown of haem, is primarily considered an antioxidant, and has long been overlooked by…”
Get full text

Cholesterol crystals drive metabolic reprogramming and M1 macrophage polarisation in primary human macrophages by O'Rourke, Sinead A., Neto, Nuno G.B., Devilly, Eimear, Shanley, Lianne C., Fitzgerald, Hannah K., Monaghan, Michael G., Dunne, Aisling

“…Metabolic reprogramming of innate immune cells is emerging as a key player in the progression of a number of chronic diseases, including atherosclerosis, where…”
Get full text

Plant-Derived Polyphenols Modulate Human Dendritic Cell Metabolism and Immune Function via AMPK-Dependent Induction of Heme Oxygenase-1 by Campbell, Nicole K, Fitzgerald, Hannah K, Fletcher, Jean M, Dunne, Aisling

“…Polyphenols are important immunonutrients which have been investigated in the context of inflammatory and autoimmune disease due to their significant…”
Get full text

Endogenous drivers of altered immune cell metabolism by Shanley, Lianne C, Fitzgerald, Hannah K, O’Rourke, Sinead A, Dunne, Aisling

“…Dysregulated metabolism has long been recognized as a feature of many metabolic disorders. However, recent studies demonstrating that metabolic reprogramming…”
Get full text

Non-invasive classification of macrophage polarisation by 2P-FLIM and machine learning by Neto, Nuno GB, O'Rourke, Sinead A, Zhang, Mimi, Fitzgerald, Hannah K, Dunne, Aisling, Monaghan, Michael G

“…In this study, we utilise fluorescence lifetime imaging of NAD(P)H-based cellular autofluorescence as a non-invasive modality to classify two contrasting…”
Get full text

Naturally derived Heme-Oxygenase 1 inducers attenuate inflammatory responses in human dendritic cells and T cells: relevance for psoriasis treatment by Campbell, Nicole K., Fitzgerald, Hannah K., Malara, Anna, Hambly, Roisin, Sweeney, Cheryl M., Kirby, Brian, Fletcher, Jean M., Dunne, Aisling

“…Psoriasis is a chronic autoimmune disease mediated by dysregulated immune responses in dendritic cells (DC) and T cells. The stress-response enzyme heme…”
Get full text

Staphylococcus aureus suppresses the pentose phosphate pathway in human neutrophils via the adenosine receptor A2aR to enhance intracellular survival by Vozza, Emilio G, Daly, Clíodhna M, O'Rourke, Sinead A, Fitzgerald, Hannah K, Dunne, Aisling, McLoughlin, Rachel M

“…is one of the leading causes of antimicrobial-resistant infections whose success as a pathogen is facilitated by its massive array of immune evasion tactics,…”
Get full text

Trypanosoma brucei Secreted Aromatic Ketoacids Activate the Nrf2/HO-1 Pathway and Suppress Pro-inflammatory Responses in Primary Murine Glia and Macrophages by Campbell, Nicole K, Williams, David G, Fitzgerald, Hannah K, Barry, Paul J, Cunningham, Clare C, Nolan, Derek P, Dunne, Aisling

“…African trypanosomes, such as ( ), are protozoan parasites of the mammalian vasculature and central nervous system that are best known for causing fatal human…”
Get full text

The Trypanosoma brucei -Derived Ketoacids, Indole Pyruvate and Hydroxyphenylpyruvate, Induce HO-1 Expression and Suppress Inflammatory Responses in Human Dendritic Cells by Fitzgerald, Hannah K, O'Rourke, Sinead A, Desmond, Eva, Neto, Nuno G B, Monaghan, Michael G, Tosetto, Miriam, Doherty, Jayne, Ryan, Elizabeth J, Doherty, Glen A, Nolan, Derek P, Fletcher, Jean M, Dunne, Aisling

“…The extracellular parasite and causative agent of African sleeping sickness ( ) has evolved a number of strategies to avoid immune detection in the host. One…”
Get full text

"No more amputations": a complex scientific problem and a challenge for effective preventive strategy implementation on vascular field by Kolossváry, Endre, Farkas, Katalin, Colgan, Mary P, Edmonds, Michael, Fitzgerald, Hannah P, Fox, Martin, Pécsvárady, Zsolt, Wautrecht, Jean C, Catalano, Mariella

“…Lower limb vascular amputations represent serious problem in the vascular care. As a consequence of critical limb ischemia, often associated with diabetes, it…”
Get more information

Manipulating Liquid Metal Droplets in Microfluidic Channels With Minimized Skin Residues Toward Tunable RF Applications by Koo, Chiwan, LeBlanc, Brittany E., Kelley, Michael, Fitzgerald, Hannah E., Huff, Gregory H., Han, Arum

“…A nontoxic liquid metal, such as eutectic gallium-indium (EGaIn) alloy, has been used to develop tunable radio frequency (RF) components, such as antennas,…”
Get full text

Resolvin D2-G-Protein Coupled Receptor 18 Enhances Bone Marrow Function and Limits Steatosis and Hepatic Collagen Accumulation in Aging by Fitzgerald, Hannah, Bonin, Jesse L, Khan, Sayeed, Eid, Maya, Sadhu, Sudeshna, Rahtes, Allison, Lipscomb, Masharh, Biswas, Nirupam, Decker, Christa, Nabage, Melisande, Ramos, Ramon Bossardi, Duarte, Giesse Albeche, Marinello, Michael, Chen, Anne, Aydin, Hasan Basri, Mena, Hebe Agustina, Gilliard, Kurrim, Spite, Matthew, DiPersio, C Michael, Adam, Alejandro P, MacNamara, Katherine C, Fredman, Gabrielle

“…Aging is associated with nonresolving inflammation and tissue dysfunction. Resolvin D2 (RvD2) is a proresolving ligand that acts through the G-protein-coupled…”
Get full text

The RvD2-GPR18 Axis Limits Steatosis and Collagen Accumulation in Livers of Middle-Aged Mice by Fitzgerald, Hannah Gilroy

“…The resolution of inflammation (or inflammation-resolution) is a critical protective response that is mediated, in part, by specialized pro-resolving mediators…”
Get full text