Search Results - "FitzPatrick, Michael E. B."

A conserved population of MHC II-restricted, innate-like, commensal-reactive T cells in the gut of humans and mice by Hackstein, Carl-Philipp, Costigan, Dana, Drexhage, Linnea, Pearson, Claire, Bullers, Samuel, Ilott, Nicholas, Akther, Hossain Delowar, Gu, Yisu, FitzPatrick, Michael E. B., Harrison, Oliver J., Garner, Lucy C., Mann, Elizabeth H., Pandey, Sumeet, Friedrich, Matthias, Provine, Nicholas M., Uhlig, Holm H., Marchi, Emanuele, Powrie, Fiona, Klenerman, Paul, Thornton, Emily E.

“…Interactions with commensal microbes shape host immunity on multiple levels and play a pivotal role in human health and disease. Tissue-dwelling,…”
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MAIT cell activation augments adenovirus vector vaccine immunogenicity by Provine, Nicholas M, Amini, Ali, Garner, Lucy C, Spencer, Alexandra J, Dold, Christina, Hutchings, Claire, Silva Reyes, Laura, FitzPatrick, Michael E B, Chinnakannan, Senthil, Oguti, Blanche, Raymond, Meriel, Ulaszewska, Marta, Troise, Fulvia, Sharpe, Hannah, Morgan, Sophie B, Hinks, Timothy S C, Lambe, Teresa, Capone, Stefania, Folgori, Antonella, Barnes, Eleanor, Rollier, Christine S, Pollard, Andrew J, Klenerman, Paul

“…Mucosal-associated invariant T (MAIT) cells are innate sensors of viruses and can augment early immune responses and contribute to protection. We hypothesized…”
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Single-cell analysis of human MAIT cell transcriptional, functional and clonal diversity by Garner, Lucy C., Amini, Ali, FitzPatrick, Michael E. B., Lett, Martin J., Hess, Gabriel F., Filipowicz Sinnreich, Magdalena, Provine, Nicholas M., Klenerman, Paul

“…Mucosal-associated invariant T (MAIT) cells are innate-like T cells that recognize microbial metabolites through a semi-invariant T cell receptor (TCR). Major…”
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The role of the future physician: building on shifting sands by Fernandes, Linford, FitzPatrick, Michael EB, Roycroft, Matthew

“…The role of the future physician in the NHS is of interest to current doctors, patients, policymakers and the wider public. Amid the COVID-19 pandemic, it has…”
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Unique and Common Features of Innate-Like Human Vδ2 + γδT Cells and Mucosal-Associated Invariant T Cells by Provine, Nicholas M, Binder, Benedikt, FitzPatrick, Michael E B, Schuch, Anita, Garner, Lucy C, Williamson, Kate D, van Wilgenburg, Bonnie, Thimme, Robert, Klenerman, Paul, Hofmann, Maike

“…Mucosal-associated invariant T (MAIT) cells are innate-like T cells abundant in humans that can be activated in a TCR-independent manner by inflammatory and…”
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Interferon-Gamma–Producing CD8+ Tissue Resident Memory T Cells Are a Targetable Hallmark of Immune Checkpoint Inhibitor–Colitis by Sasson, Sarah C., Slevin, Stephanie M., Cheung, Vincent T.F., Nassiri, Isar, Olsson-Brown, Anna, Fryer, Eve, Ferreira, Ricardo C., Trzupek, Dominik, Gupta, Tarun, Al-Hillawi, Lulia, Issaias, Mari-lenna, Easton, Alistair, Campo, Leticia, FitzPatrick, Michael E.B., Adams, Joss, Chitnis, Meenali, Protheroe, Andrew, Tuthill, Mark, Coupe, Nicholas, Simmons, Alison, Payne, Miranda, Middleton, Mark R., Travis, Simon P.L., Fairfax, Benjamin P., Klenerman, Paul, Brain, Oliver

“…The pathogenesis of immune checkpoint inhibitor (ICI)–colitis remains incompletely understood. We sought to identify key cellular drivers of ICI-colitis and…”
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Human intestinal tissue-resident memory T cells comprise transcriptionally and functionally distinct subsets by FitzPatrick, Michael E.B., Provine, Nicholas M., Garner, Lucy C., Powell, Kate, Amini, Ali, Irwin, Sophie L., Ferry, Helen, Ambrose, Tim, Friend, Peter, Vrakas, Georgios, Reddy, Srikanth, Soilleux, Elizabeth, Klenerman, Paul, Allan, Philip J.

“…Tissue-resident memory T (TRM) cells provide key adaptive immune responses in infection, cancer, and autoimmunity. However, transcriptional heterogeneity of…”
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Adenovirus vectors activate Vδ2+ γδT cells in a type I interferon‐, TNF‐, and IL‐18‐dependent manner by Provine, Nicholas M., Amini, Ali, Garner, Lucy C., FitzPatrick, Michael E.B., Dold, Christina, Silva Reyes, Laura, Chinnakannan, Senthil, Oguti, Blanche, Raymond, Meriel, Troise, Fulvia, Capone, Stefania, Folgori, Antonella, Barnes, Eleanor, Rollier, Christine S., Pollard, Andrew J., Klenerman, Paul

“…Vδ2+ γδT cells are unconventional T cells that can be activated by cytokines without TCR signaling. Adenovirus vaccine vectors activated Vδ2+ γδT cells in an…”
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Nutritional care pathways in cancer patients with malignant bowel obstruction: A retrospective multi-centre study by Patel, Pinal S, Fragkos, Konstantinos, Keane, Niamh, Wilkinson, David, Johnson, Amy, Chan, Derek, Roberts, Bradley, Neild, Penny, Yalcin, Metin, Allan, Philip, FitzPatrick, Michael E B, Gomez, Michael, Williams, Sarah, Kok, Klaartje, Sharkey, Lisa, Swift, Carla, Mehta, Shameer, Naghibi, Mani, Mountford, Christopher, Forbes, Alastair, Rahman, Farooq, Di Caro, Simona

“…Variation in access to parenteral nutrition (PN) in patients with intestinal failure secondary to malignant bowel obstruction (MBO) exists due to differing…”
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Classification of intestinal T‐cell receptor repertoires using machine learning methods can identify patients with coeliac disease regardless of dietary gluten status by Foers, Andrew D, Shoukat, M Saad, Welsh, Oliver E, Donovan, Killian, Petry, Russell, Evans, Shelley C, FitzPatrick, Michael EB, Collins, Nadine, Klenerman, Paul, Fowler, Anna, Soilleux, Elizabeth J

“…In coeliac disease (CeD), immune‐mediated small intestinal damage is precipitated by gluten, leading to variable symptoms and complications, occasionally…”
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‘Attorneys of the poor’: Training physicians to tackle health inequalities by FitzPatrick, Michael EB, Badu-Boateng, Charles, Huntley, Christopher, Morgan, Caitlin

“…The stellar gains in life expectancy and health over the past century have been accompanied by an increase in societal and health inequalities. This health gap…”
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