Search Results - "Fitz, Y"

Controlled trials of rG-CSF and CD11b-directed MAb during hyperoxia and E. coli pneumonia in rats by Freeman, B D, Correa, R, Karzai, W, Natanson, C, Patterson, M, Banks, S, Fitz, Y, Danner, R L, Wilson, L, Eichacker, P Q

“…We studied the effects of inhibiting and augmenting neutrophil function by using an immunocompetent rat model of infectious and hyperoxic lung injury. After…”
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C54 CRITICAL CARE: TRANSLATIONAL INSIGHTS INTO ARDS AND SEPSIS - FROM BENCH TO BEDSIDE: B. Anthracis Edema Toxin But Not Lethal Toxin Depresses The Contractile Response Of Rat Aortic Tissue To Phenylephrine In An In-Vivo And In An Ex-Vivo Aortic Ring Model by Suffredini, D A, Cui, X, Li, Y, Fitz, Y, Eichacker, P

“…To further investigate the effects of ET and LT on arterial contractile function, we tested whether aortic rings prepared from rats challenged in vivo with…”
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A104 CRITICAL CARE: SEPSIS TRANSLATIONAL INSIGHTS: Hydrocortisone Treatment Decreases Nitric Oxide Levels And Increases Blood Pressure And Survival Following B. Anthracis Cell Wall Peptidoglycan Challenge In Rats by Suffredini, D A, Cui, X, Li, Y, Fitz, Y, Eichacker, P

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B24 MECHANISMS OF INJURY IN SEPSIS: INFLAMMATION, OXIDATION, AND ENDOTHELIAL DAMAGE: Nitric Oxide Synthase Inhibition Improves Hemodynamics And Survival In B. Anthracis Edema Toxin Challenged Rats by Li, Y, Namagerdi, L Ohanjanian, Sampath-Kumar, H, Cui, X, Fitz, Y, Eichacker, P Q

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A47 CRITICAL ILLNESS: NOVEL MOLECULES AND MODELS: Nitric Oxide Contributes To The Arterial Relaxant Effects Of B. Anthracis Edema Toxin In The Rat Aortic Ring Model by Li, Y, Cui, X, Malide, D A, Yu, Z, Fitz, Y, Eichacker, P Q

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B24 MECHANISMS OF INJURY IN SEPSIS: INFLAMMATION, OXIDATION, AND ENDOTHELIAL DAMAGE: The Development And Implementation Of An Isolated Perfused Rat Kidney Model To Study Renal Tubular Function by Jaswal, D S, Namagerdi, L Ohanjanian, Sampath-Kumar, H, Fitz, Y, Li, Y, Cui, X, Eichacker, P Q

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B24 MECHANISMS OF INJURY IN SEPSIS: INFLAMMATION, OXIDATION, AND ENDOTHELIAL DAMAGE: B. Anthracis Edema Toxin Increases Fractional Free Water Reabsorption In An Isolated Perfused Rat Kidney Model by Jaswal, D S, Sampath-Kumar, H, Namagerdi, L Ohanjanian, Fitz, Y, Li, Y, Cui, X, Eichacker, P Q

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Risk and the Efficacy of Antiinflammatory Agents: Retrospective and Confirmatory Studies of Sepsis by Eichacker, Peter Q, Parent, Chantal, Kalil, Andre, Esposito, Claire, Cui, Xizhong, Banks, Steven M, Gerstenberger, Eric P, Fitz, Yvonne, Danner, Robert L, Natanson, Charles

“…We investigated whether a relationship between risk of death and treatment effect could explain the disparate results between the preclinical and clinical…”
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A47 CRITICAL ILLNESS: NOVEL MOLECULES AND MODELS: Treatment With 3-MorpholINOSydnoime (sin-1), An No And O2- Donor Agent, Improves Survival In Bacillus Anthracis Lethal Toxin-Challenged Rats by Qiu, P, Cui, X, Li, Y, Fitz, Y, Ferreyra, G, Wang, S, Wang, H, Moayeri, M, Leppla, S, Suffredini, A F, Danner, R, Eichacker, P Q

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Lethality during continuous anthrax lethal toxin infusion is associated with circulatory shock but not inflammatory cytokine or nitric oxide release in rats by Cui, Xizhong, Moayeri, Mahtab, Li, Yan, Li, Xuemei, Haley, Michael, Fitz, Yvonne, Correa-Araujo, Rosaly, Banks, Steven M, Leppla, Stephen H, Eichacker, Peter Q

“…Although circulatory shock related to lethal toxin (LeTx) may play a primary role in lethality due to Bacillus anthracis infection, its mechanisms are unclear…”
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Late Treatment with a Protective Antigen-Directed Monoclonal Antibody Improves Hemodynamic Function and Survival in a Lethal Toxin-Infused Rat Model of Anthrax Sepsis by Cui, Xizhong, Li, Yan, Moayeri, Mahtab, Choi, Gil H., Subramanian, G. M., Li, Xuemei, Haley, Michael, Fitz, Yvonne, Feng, Jing, Banks, Steven M., Leppla, Stephen H., Eichacker, Peter Q.

“…Background. In animal models, treatment with 5H3, a fully human protective antigen-directed monoclonal antibody (PA-MAb), improved survival when administered…”
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Sublethal Doses of Bacillus anthracis Lethal Toxin Inhibit Inflammation with Lipopolysaccharide and Escherichia coli Challenge but Have Opposite Effects on Survival by Cui, Xizhong, Li, Yan, Li, Xuemei, Haley, Michael, Moayeri, Mahtab, Fitz, Yvonne, Leppla, Stephen H., Eichacker, Peter Q.

“…BackgroundOn the basis of the findings of previous in vitro studies, we hypothesized that anthrax lethal toxin (LeTx) would have anti-inflammatory effects in…”
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Parthenolide has limited effects on nuclear factor-κβ increases and worsens survival in lipopolysaccharide-challenged C57BL/6J mice by Li, Xuemei, Cui, Xizhong, Li, Yan, Fitz, Yvonne, Hsu, Lewis, Eichacker, Peter Q.

“…Parthenolide, a sesquiterpene lactone, inhibited lipopolysaccharide (LPS) stimulated nuclear factor (NF)-κβ and cytokine production in vitro and in rats, and…”
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Effective Dosing of Lipid A Analogue E5564 in Rats Depends on the Timing of Treatment and the Route of Escherichia coli Infection by Solomon, Steven B., Cui, Xizhong, Gerstenberger, Eric, Danner, Robert L., Fitz, Yvonne, Banks, Steven M., Natanson, Charles, Eichacker, Peter Q.

“…BackgroundE5564, a competitive lipid A antagonist, inhibits endotoxin-stimulated inflammation and is under study in patients with sepsis MethodsWe tested…”
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Neutrophil inhibition with L-selectin-directed MAb improves or worsens survival dependent on the route but not severity of infection in a rat sepsis model by Haley, Michael, Parent, Chantal, Cui, Xizhong, Kalil, Andre, Fitz, Yvonne, Correa-Araujo, Rosaly, Natanson, Charles, Danner, Robert L, Banks, Steven M, Eichacker, Peter Q

“…Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland Submitted 4 November 2004 ; accepted in final form 26…”
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Severity of sepsis alters the effects of superoxide anion inhibition in a rat sepsis model by Cui, Xizhong, Parent, Chantal, Macarthur, Heather, Ochs, Scott D, Gerstenberg, Eric, Solomon, Steve, Fitz, Yvonne, Danner, Robert L, Banks, Steven M, Natanson, Charles, Salvemini, Daniela, Eichacker, Peter Q

“…1 Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland 20892; 2 Department of Pharmacological and…”
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TGF- beta 1 increases microbial clearance but worsens lung injury during Escherichia coli pneumonia in rats by Cui, X, Zeni, F, Vodovitz, Y, Correa-de-Araujo, R, Quezado, M, Roberts, A, Wahl, S, Danner, R L, Banks, S M, Gerstenberger, E, Fitz, Y, Natanson, C, Eichacker, P Q

“…We investigated the effects of either intravenous (IV) or intrabronchial (IB) treatment with transforming growth factor beta 1 (TGF- beta 1) during bacterial…”
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Acute G-CSF therapy is not protective during lethal E. coli sepsis by Quezado, Z, Parent, C, Karzai, W, Depietro, M, Natanson, C, Hammond, W, Danner, R L, Cui, X, Fitz, Y, Banks, S M, Gerstenberger, E, Eichacker, P Q

“…We investigated whether decreases in circulating polymorphonuclear neutrophils (PMN) during lethal Escherichia coli (E. coli) sepsis in canines are related to…”
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rG-CSF reduces endotoxemia and improves survival during E. coli pneumonia by Freeman, Bradley D, Quezado, Zenaide, Zeni, Fabrice, Natanson, Charles, Danner, Robert L, Banks, Steven, Quezado, Marcello, Fitz, Yvonne, Bacher, John, Eichacker, Peter Q

“…Bradley D. Freeman, Zenaide Quezado, Fabrice Zeni, Charles Natanson, Robert L. Danner, Steven Banks, Marcello Quezado, Yvonne Fitz, John Bacher, and Peter Q…”
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ICAM-1 and CD11b inhibition worsen outcome in rats with E. coli pneumonia by Zeni, Fabrice, Parent, Chantal, Correa, Rosaly, Natanson, Charles, Freeman, Bradley, Fontana, Joseph, Quezado, Marcello, Danner, Robert L, Fitz, Yvonne, Richmond, Steve, Gerstenberger, Eric, Banks, Steven M, Eichacker, Peter Q

“…Critical Care Medicine Department, National Institutes of Health, Bethesda, Maryland 20892-1662 We investigated whether inhibiting an endothelial adhesion…”
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