Search Results - "Fitz, Stephanie D."

A selective orexin-1 receptor antagonist attenuates stress-induced hyperarousal without hypnotic effects by Bonaventure, Pascal, Yun, Sujin, Johnson, Philip L, Shekhar, Anantha, Fitz, Stephanie D, Shireman, Brock T, Lebold, Terry P, Nepomuceno, Diane, Lord, Brian, Wennerholm, Michelle, Shelton, Jonathan, Carruthers, Nicholas, Lovenberg, Timothy, Dugovic, Christine

“…Orexins (OXs) are peptides produced by perifornical (PeF) and lateral hypothalamic neurons that exert a prominent role in arousal-related processes, including…”
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Orexin 1 receptors are a novel target to modulate panic responses and the panic brain network by Johnson, Philip L, Samuels, Brian C, Fitz, Stephanie D, Federici, Lauren M, Hammes, Nathan, Early, Maureen C, Truitt, William, Lowry, Christopher A, Shekhar, Anantha

“…Abstract Background Although the hypothalamic orexin system is known to regulate appetitive behaviors and promote wakefulness and arousal (Sakurai, 2007 [56]…”
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Pharmacological depletion of serotonin in the basolateral amygdala complex reduces anxiety and disrupts fear conditioning by Johnson, Philip L., Molosh, Andrei, Fitz, Stephanie D., Arendt, Dave, Deehan, Gerald A., Federici, Lauren M., Bernabe, Cristian, Engleman, Eric A., Rodd, Zachary A., Lowry, Christopher A., Shekhar, Anantha

“…•5,7-DHT injections into BLC/CeA+i.p. desipramine increase social interaction behaviors.•5,7-DHT injections into BLC/CeA+i.p. desipramine disrupt acquisition…”
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Orexin Depolarizes Central Amygdala Neurons via Orexin Receptor 1, Phospholipase C and Sodium-Calcium Exchanger and Modulates Conditioned Fear by Dustrude, Erik T, Caliman, Izabela F, Bernabe, Cristian S, Fitz, Stephanie D, Grafe, Laura A, Bhatnagar, Seema, Bonaventure, Pascal, Johnson, Philip L, Molosh, Andrei I, Shekhar, Anantha

“…Orexins (OX), also known as hypocretins, are excitatory neuropeptides with well-described roles in regulation of wakefulness, arousal, energy homeostasis, and…”
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Evaluation of JNJ-54717793 a Novel Brain Penetrant Selective Orexin 1 Receptor Antagonist in Two Rat Models of Panic Attack Provocation by Bonaventure, Pascal, Dugovic, Christine, Shireman, Brock, Preville, Cathy, Yun, Sujin, Lord, Brian, Nepomuceno, Diane, Wennerholm, Michelle, Lovenberg, Timothy, Carruthers, Nicolas, Fitz, Stephanie D, Shekhar, Anantha, Johnson, Philip L

“…Orexin neurons originating in the perifornical and lateral hypothalamic area are highly reactive to anxiogenic stimuli and have strong projections to anxiety…”
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Anxiogenic CO2 stimulus elicits exacerbated hot flash-like responses in a rat menopause model and hot flashes in postmenopausal women by Federici, Lauren M, Roth, Sarah Dorsey, Krier, Connie, Fitz, Stephanie D, Skaar, Todd, Shekhar, Anantha, Carpenter, Janet S, Johnson, Philip L

“…OBJECTIVE:As longitudinal studies determined that anxiety is a strong risk factor for hot flashes, we hypothesized that an anxiogenic stimulus that signals air…”
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Evaluation of Low versus High Volume per Minute Displacement CO₂ Methods of Euthanasia in the Induction and Duration of Panic-Associated Behavior and Physiology by Hickman, Debra L, Fitz, Stephanie D, Bernabe, Cristian S, Caliman, Izabela F, Haulcomb, Melissa M, Federici, Lauren M, Shekhar, Anantha, Johnson, Philip L

“…Current recommendations for the use of CO ₂ as a euthanasia agent for rats require the use of gradual fill protocols (such as 10% to 30% volume displacement…”
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Stress and central Urocortin increase anxiety-like behavior in the social interaction test via the CRF1 receptor by GEHLERT, Donald R, SHEKHAR, Anantha, MORIN, S. Michelle, HIPSKIND, Phillip A, ZINK, Charity, GACKENHEIMER, Susan L, SHAW, Janice, FITZ, Stephanie D, SAJDYK, Tammy J

“…Corticotropin releasing factor (CRF) and Urocortin are important neurotransmitters in the regulation of physiological and behavioral responses to stress…”
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The role of neuropeptide Y in the amygdala on corticotropin-releasing factor receptor-mediated behavioral stress responses in the rat by Sajdyk, Tammy J, Fitz, Stephanie D, Shekhar, Anantha

“…Neuropeptide Y (NPY) is one of the most abundant peptides in the brain and has been shown to be a critical regulator of emotionality, most notably for its…”
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A key role for orexin in panic anxiety by Shekhar, Anantha, Johnson, Philip L, Truitt, William, Fitz, Stephanie D, Minick, Pamela E, Dietrich, Amy, Sanghani, Sonal, Träskman-Bendz, Lil, Goddard, Andrew W, Brundin, Lena

“…Panic disorder is a severe anxiety disorder with recurrent, debilitating panic attacks. In individuals with panic disorder there is evidence of decreased…”
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The small molecule GAT1508 activates brain-specific GIRK1/2 channel heteromers and facilitates conditioned fear extinction in rodents by Xu, Yu, Cantwell, Lucas, Molosh, Andrei I., Plant, Leigh D., Gazgalis, Dimitris, Fitz, Stephanie D., Dustrude, Erik T., Yang, Yuchen, Kawano, Takeharu, Garai, Sumanta, Noujaim, Sami F., Shekhar, Anantha, Logothetis, Diomedes E., Thakur, Ganesh A.

“…G-protein–gated inwardly-rectifying K+ (GIRK) channels are targets of Gi/o-protein–signaling systems that inhibit cell excitability. GIRK channels exist as…”
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Orexin, stress, and anxiety/panic states by Johnson, Philip L, Molosh, Andrei, Fitz, Stephanie D, Truitt, William A, Shekhar, Anantha

“…A panic response is an adaptive response to deal with an imminent threat and consists of an integrated pattern of behavioral (aggression, fleeing, or freezing)…”
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Activation of the orexin 1 receptor is a critical component of CO2-mediated anxiety and hypertension but not bradycardia by Johnson, Philip L, Samuels, Brian C, Fitz, Stephanie D, Lightman, Stafford L, Lowry, Christopher A, Shekhar, Anantha

“…Acute hypercapnia (elevated arterial CO(2)/H(+)) is a suffocation signal that is life threatening and rapidly mobilizes adaptive changes in breathing and…”
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OREXIN 1 AND 2 RECEPTOR INVOLVEMENT IN CO2-INDUCED PANIC-ASSOCIATED BEHAVIOR AND AUTONOMIC RESPONSES by Johnson, Philip L., Federici, Lauren M., Fitz, Stephanie D., Renger, John J., Shireman, Brock, Winrow, Christopher J., Bonaventure, Pascal, Shekhar, Anantha

“…Background The neuropeptides orexin A and B play a role in reward and feeding and are critical for arousal. However, it was not initially appreciated that most…”
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Crh receptor priming in the bed nucleus of the stria terminalis (BNST) induces tph2 gene expression in the dorsomedial dorsal raphe nucleus and chronic anxiety by Donner, Nina C., Davies, Sofia M., Fitz, Stephanie D., Kienzle, Drake M., Shekhar, Anantha, Lowry, Christopher A.

“…The bed nucleus of the stria terminalis (BNST) is a nodal structure in neural circuits controlling anxiety-related defensive behavioral responses. It contains…”
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Suppression of inflammatory and neuropathic pain by uncoupling CRMP-2 from the presynaptic Ca2+ channel complex by Brittain, Joel M, Duarte, Djane B, Wilson, Sarah M, Zhu, Weiguo, Ballard, Carrie, Johnson, Philip L, Liu, Naikui, Xiong, Wenhui, Ripsch, Matthew S, Wang, Yuying, Fehrenbacher, Jill C, Fitz, Stephanie D, Khanna, May, Park, Chul-Kyu, Schmutzler, Brian S, Cheon, Bo Myung, Due, Michael R, Brustovetsky, Tatiana, Ashpole, Nicole M, Hudmon, Andy, Meroueh, Samy O, Hingtgen, Cynthia M, Brustovetsky, Nickolay, Ji, Ru-Rong, Hurley, Joyce H, Jin, Xiaoming, Shekhar, Anantha, Xu, Xiao-Ming, Oxford, Gerry S, Vasko, Michael R, White, Fletcher A, Khanna, Rajesh

“…Drugs that block calcium channels reduce pain, but they can cause unwanted side effects. Now, Rajesh Khanna and his colleagues show that a peptide that…”
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Select panicogenic drugs and stimuli induce consistent increases in tail skin flushes and decreases in core body temperature by Federici, Lauren M, Caliman, Izabela F, Fitz, Stephanie D, Shekhar, Anantha, Johnson, Philip L

“…Panic attacks (PAs) are episodes of intense fear or discomfort that are accompanied by a variety of both psychological and somatic symptoms. Panic induction in…”
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Sustained relief of ongoing experimental neuropathic pain by a CRMP2 peptide aptamer with low abuse potential by Xie, Jennifer Y., Chew, Lindsey A., Yang, Xiaofang, Wang, Yuying, Qu, Chaoling, Wang, Yue, Federici, Lauren M., Fitz, Stephanie D., Ripsch, Matthew S., Due, Michael R., Moutal, Aubin, Khanna, May, White, Fletcher A., Vanderah, Todd W., Johnson, Philip L., Porreca, Frank, Khanna, Rajesh

“…Uncoupling the protein-protein interaction between collapsin response mediator protein 2 (CRMP2) and N-type voltage-gated calcium channel (CaV2.2) with an…”
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Assessment of fear and anxiety associated behaviors, physiology and neural circuits in rats with reduced serotonin transporter (SERT) levels by Johnson, Philip L., Molosh, Andrei I., Federici, Lauren M., Bernabe, Cristian, Haggerty, David, Fitz, Stephanie D., Nalivaiko, Eugene, Truitt, William, Shekhar, Anantha

“…Genetic variation in serotonin transporter (SERT) that reduces transcriptional efficiency is associated with higher anxiety and fear traits and a greater…”
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Electroacupuncture Promotes Central Nervous System‐Dependent Release of Mesenchymal Stem Cells by Salazar, Tatiana E., Richardson, Matthew R., Beli, Eleni, Ripsch, Matthew S., George, John, Kim, Youngsook, Duan, Yaqian, Moldovan, Leni, Yan, Yuanqing, Bhatwadekar, Ashay, Jadhav, Vaishnavi, Smith, Jared A., McGorray, Susan, Bertone, Alicia L., Traktuev, Dmitri O., March, Keith L., Colon‐Perez, Luis M., Avin, Keith G., Sims, Emily, Mund, Julie A., Case, Jamie, Deng, Xiaolin, Kim, Min Su, McDavitt, Bruce, Boulton, Michael E., Thinschmidt, Jeffrey, Li Calzi, Sergio, Fitz, Stephanie D., Fuchs, Robyn K., Warden, Stuart J., McKinley, Todd, Shekhar, Anantha, Febo, Marcelo, Johnson, Phillip L., Chang, Lung-Ji, Gao, Zhanguo, Kolonin, Mikhail G., Lai, Song, Ma, Jingfeng, Dong, Xinzhong, White, Fletcher A., Xie, Huisheng, Yoder, Mervin C., Grant, Maria B.

“…Electroacupuncture (EA) performed in rats and humans using limb acupuncture sites, LI‐4 and LI‐11, and GV‐14 and GV‐20 (humans) and Bai‐hui (rats) increased…”
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