Search Results - "Fitter, Stephen"

The Mesenchymal Precursor Cell Marker Antibody STRO‐1 Binds to Cell Surface Heat Shock Cognate 70 by Fitter, Stephen, Gronthos, Stan, Ooi, Soo Siang, Zannettino, Andrew C.W.

“…Since its discovery more than 25 years ago, the STRO‐1 antibody has played a fundamental role in defining the hierarchical nature of mesenchymal precursor…”
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mTORC1 Plays an Important Role in Skeletal Development by Controlling Preosteoblast Differentiation by Fitter, Stephen, Matthews, Mary P., Martin, Sally K., Xie, Jianling, Ooi, Soo Siang, Walkley, Carl R., Codrington, John D., Ruegg, Markus A., Hall, Michael N., Proud, Christopher G., Gronthos, Stan, Zannettino, Andrew C. W.

“…The mammalian target of rapamycin complex 1 (mTORC1) is activated by extracellular factors that control bone accrual. However, the direct role of this complex…”
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Osteocalcin‐dependent regulation of glucose metabolism and fertility: Skeletal implications for the development of insulin resistance by Tangseefa, Pawanrat, Martin, Sally K., Fitter, Stephen, Baldock, Paul A., Proud, Christopher G., Zannettino, Andrew C. W.

“…The skeleton has recently emerged as a critical insulin target tissue that regulates whole body glucose metabolism and male reproductive function. While our…”
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Calorie restriction has no effect on bone marrow tumour burden in a VkMYC transplant model of multiple myeloma by Bradey, Alanah L., Fitter, Stephen, Duggan, Jvaughn, Wilczek, Vicki, Williams, Connor M. D., Cheney, Emma AJ, Noll, Jacqueline E., Tangseefa, Pawanrat, Panagopoulos, Vasilios, Zannettino, Andrew C. W.

“…Multiple myeloma (MM) is an incurable haematological malignancy, caused by the uncontrolled proliferation of plasma cells within the bone marrow (BM). Obesity…”
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Dysregulation of bone remodeling by imatinib mesylate by Vandyke, Kate, Fitter, Stephen, Dewar, Andrea L., Hughes, Timothy P., Zannettino, Andrew C.W.

“…Imatinib mesylate is a rationally designed tyrosine kinase inhibitor that has revolutionized the treatment of chronic myeloid leukemia and gastrointestinal…”
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Suppression of PDGF-induced PI3 kinase activity by imatinib promotes adipogenesis and adiponectin secretion by Fitter, Stephen, Vandyke, Kate, Gronthos, Stan, Zannettino, Andrew C W

“…Improved glucose and lipid metabolism is a unique side effect of imatinib therapy in some chronic myeloid leukaemia (CML) patients. We recently reported that…”
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Long-term imatinib therapy promotes bone formation in CML patients by Fitter, Stephen, Dewar, Andrea L., Kostakis, Panagiota, To, L. Bik, Hughes, Timothy P., Roberts, Marion M., Lynch, Kevin, Vernon-Roberts, Barrie, Zannettino, Andrew C.W.

“…Imatinib inhibits tyrosine kinases important in osteoclast (c-Fms) and osteoblast (platelet-derived growth factor receptor [PDGF-R], c-Abl) function,…”
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The tyrosine kinase inhibitor dasatinib dysregulates bone remodeling through inhibition of osteoclasts in vivo by Vandyke, Kate, Dewar, Andrea L, Diamond, Peter, Fitter, Stephen, Schultz, Christopher G, Sims, Natalie A, Zannettino, Andrew CW

“…Dasatinib is a potent tyrosine kinase inhibitor that is used to treat chronic myeloid leukemia in patients resistant or intolerant to imatinib mesylate. While…”
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Plasma Adiponectin Levels Are Markedly Elevated in Imatinib-Treated Chronic Myeloid Leukemia (CML) Patients: A Mechanism for Improved Insulin Sensitivity in Type 2 Diabetic CML Patients? by Fitter, Stephen, Vandyke, Kate, Schultz, Christopher G., White, Deborah, Hughes, Timothy P., Zannettino, Andrew C. W.

“…Context: The mechanism(s) by which imatinib improves glycemic control in chronic myeloid leukemia (CML) patients with type 2 diabetes remains unclear…”
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NVP‐BEZ235, a dual pan class I PI3 kinase and mTOR inhibitor, promotes osteogenic differentiation in human mesenchymal stromal cells by Martin, Sally K, Fitter, Stephen, Bong, Li Fei, Drew, Jennifer J, Gronthos, Stan, Shepherd, Peter R, Zannettino, Andrew CW

“…Osteoblasts are bone‐forming cells derived from mesenchymal stromal cells (MSCs) that reside within the bone marrow. In response to a variety of factors, MSCs…”
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A novel monoclonal antibody (STRO-3) identifies an isoform of tissue nonspecific alkaline phosphatase expressed by multipotent bone marrow stromal stem cells by Gronthos, Stan, Fitter, Stephen, Diamond, Peter, Simmons, Paul J, Itescu, Silviu, Zannettino, Andrew C W

“…Numerous studies support the concept that the nonhemopoietic cells of the bone marrow (BM), are derived from a population of multipotent bone marrow stromal…”
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Characterization of Mice Lacking the Tetraspanin Superfamily Member CD151 by Wright, Mark D., Geary, Sean M., Fitter, Stephen, Moseley, Gregory W., Lau, Lai-Man, Sheng, Kuo-Ching, Apostolopoulos, Vasso, Stanley, Edouard G., Jackson, Denise E., Ashman, Leonie K.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The mTORC1 complex in pre-osteoblasts regulates whole-body energy metabolism independently of osteocalcin by Tangseefa, Pawanrat, Martin, Sally K, Chin, Peck Yin, Breen, James, Mah, Chui Yan, Baldock, Paul A, Wittert, Gary A, Page, Amanda J, Proud, Christopher G, Fitter, Stephen, Zannettino, Andrew C W

“…Overnutrition causes hyperactivation of mTORC1-dependent negative feedback loops leading to the downregulation of insulin signaling and development of insulin…”
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Characterization of the role of Samsn1 loss in multiple myeloma development by Friend, Natasha L., Hewett, Duncan R., Panagopoulos, Vasilios, Noll, Jacqueline E., Vandyke, Kate, Mrozik, Krzysztof M., Fitter, Stephen, Zannettino, Andrew C.W.

“…The protein SAMSN1 was recently identified as a putative tumor suppressor in multiple myeloma, with re‐expression of Samsn1 in the 5TGM1/KaLwRij murine model…”
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Deletion of Rptor in Preosteoblasts Reveals a Role for the Mammalian Target of Rapamycin Complex 1 (mTORC1) Complex in Dietary‐Induced Changes to Bone Mass and Glucose Homeostasis in Female Mice by Tangseefa, Pawanrat, Martin, Sally K., Arthur, Agnieszka, Panagopoulos, Vasilios, Page, Amanda J., Wittert, Gary A., Proud, Christopher G., Fitter, Stephen, Zannettino, Andrew C.W.

“…ABSTRACT The mammalian target of rapamycin complex 1 (mTORC1) complex is the major nutrient sensor in mammalian cells that responds to amino acids, energy…”
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Deconvolution of a Complex Target Using DNA Aptamers by Fitter, Stephen, James, Robert

“…In vitro selection of single-stranded nucleic acid aptamers from large random sequence libraries is now a straightforward process particularly when screening…”
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Protein kinase activity of phosphoinositide 3-kinase regulates cytokine-dependent cell survival by Thomas, Daniel, Powell, Jason A, Green, Benjamin D, Barry, Emma F, Ma, Yuefang, Woodcock, Joanna, Fitter, Stephen, Zannettino, Andrew C W, Pitson, Stuart M, Hughes, Timothy P, Lopez, Angel F, Shepherd, Peter R, Wei, Andrew H, Ekert, Paul G, Guthridge, Mark A

“…The dual specificity protein/lipid kinase, phosphoinositide 3-kinase (PI3K), promotes growth factor-mediated cell survival and is frequently deregulated in…”
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Molecular and cellular mechanisms of chemoresistance in paediatric pre–B cell acute lymphoblastic leukaemia by Lill, Caleb B., Fitter, Stephen, Zannettino, Andrew C. W., Vandyke, Kate, Noll, Jacqueline E.

“…Paediatric patients with relapsed B cell acute lymphoblastic leukaemia (B-ALL) have poor prognosis, as relapse-causing clones are often refractory to common…”
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Atriplex hortensis var. 'rubra' extracts and purified amaranthin-type pigments reduce oxidative stress and inflammatory response in LPS-stimulated RAW264.7 cells by Kumorkiewicz-Jamro, Agnieszka, Pachulicz, River J., Fitter, Stephen, Górska, Renata, Duggan, Jvaughn, Vandyke, Kate, Pukala, Tara L., Wybraniec, Sławomir, Zannettino, Andrew C.W.

“…The use of direct injection ion mobility mass spectrometry (DI-IM-MS) to detect and identify betacyanin pigments in A. hortensis ‘rubra’ extracts was explored…”
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Brief Report: The Differential Roles of mTORC1 and mTORC2 in Mesenchymal Stem Cell Differentiation by Martin, Sally K., Fitter, Stephen, Dutta, Ankit K., Matthews, Mary P., Walkley, Carl R., Hall, Michael N., Ruegg, Markus A., Gronthos, Stan, Zannettino, Andrew C. W.

“…Adipocytes (AdCs) and osteoblasts (OBs) are derived from mesenchymal stem cells (MSCs) and differentiation toward either lineage is both mutually exclusive and…”
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