Search Results - "Fiskum, G"

Mitochondrial participation in ischemic and traumatic neural cell death by Fiskum, G

“…Mitochondria play critical roles in cerebral energy metabolism and in the regulation of cellular Ca2+ homeostasis. They are also the primary intracellular…”
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Anaesthetic neurotoxicity and neuroplasticity: an expert group report and statement based on the BJA Salzburg Seminar by Jevtovic-Todorovic, V, Absalom, A.R., Blomgren, K, Brambrink, A, Crosby, G, Culley, D.J., Fiskum, G, Giffard, R.G., Herold, K.F., Loepke, A.W., Ma, D, Orser, B.A., Planel, E, Slikker, W, Soriano, S.G., Stratmann, G, Vutskits, L, Xie, Z, Hemmings, H.C.

“…Although previously considered entirely reversible, general anaesthesia is now being viewed as a potentially significant risk to cognitive performance at both…”
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Sex-dependent mitophagy and neuronal death following rat neonatal hypoxia–ischemia by Demarest, T.G, Waite, E.L, Kristian, T, Puche, A.C, Waddell, J, McKenna, M.C, Fiskum, G

“…Highlights • Sex differences in mitochondrial quality control may contribute to the relative male vulnerability to HI. • Mitochondrial fission occurs, to…”
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Mitochondrial detachment of hexokinase 1 in mood and psychotic disorders: Implications for brain energy metabolism and neurotrophic signaling by Regenold, W.T, Pratt, M, Nekkalapu, S, Shapiro, P.S, Kristian, T, Fiskum, G

“…Abstract The pathophysiology of mood and psychotic disorders, including unipolar depression (UPD), bipolar disorder (BPD) and schizophrenia (SCHZ), is largely…”
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Mitochondrial dysfunction in mouse trisomy 16 brain by Bambrick, L.L, Fiskum, G

“…Abstract Mitochondrial function in the brain of mouse trisomy 16, an animal model of Down syndrome with accelerated neuron death, was studied in isolated…”
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Mechanisms of Musculoskeletal Frailty in People Living with HIV by Nelson, A K, Fiskum, G, Renn, C, Zhu, S, Kottilil, S, Klinedinst, N J

“…People over age 50 living with HIV experience frailty including functional declines and illnesses usually attributed to aging, more frequently and ten years…”
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Methoxychlor causes mitochondrial dysfunction and oxidative damage in the mouse ovary by Gupta, R.K., Schuh, R.A., Fiskum, G., Flaws, J.A.

“…Methoxychlor (MXC) is an organochlorine pesticide that reduces fertility in female rodents by causing ovarian atrophy, persistent estrous cyclicity, and antral…”
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Bcl-2 prevents mitochondrial permeability transition and cytochrome c release via maintenance of reduced pyridine nucleotides by Kowaltowski, A J, Vercesi, A E, Fiskum, G

“…Digitonin-permeabilized PC12 and GT1-7 neural cells exhibited a cyclosporin A-sensitive decrease in mitochondrial membrane potential, increased volume, and…”
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Ovarian steroid modulation of seizure severity and hippocampal cell death after kainic acid treatment by Hoffman, G.E, Moore, N, Fiskum, G, Murphy, A.Z

“…To determine whether maintained estrogen or progesterone levels affect kainic acid (KA) seizure patterns or the susceptibility of hippocampal neurons to death…”
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Bcl-2 Potentiates the Maximal Calcium Uptake Capacity of Neural Cell Mitochondria by Murphy, Anne N., Bredesen, Dale E., Cortopassi, Gino, Wang, Endi, Fiskum, Gary

“…Expression of the human protooncogene bcl-2 protects neural cells from death induced by many forms of stress, including conditions that greatly elevate…”
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Neuroprotective effects of bilobalide, a component of Ginkgo biloba extract (EGb 761) in global brain ischemia and in excitotoxicity-induced neuronal death by Chandrasekaran, K, Mehrabian, Z, Spinnewyn, B, Chinopoulos, C, Drieu, K, Fiskum, G

“…In this study, we compared the protective effect of bilobalide, a purified terpene lactone component of ginkgo biloba extract EGb 761, (definition see…”
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Distribution of hypothalamic, hippocampal and other limbic peptidergic neuronal cell bodies giving rise to retinopetal fibers: Anterograde and retrograde tracing and neuropeptide immunohistochemical studies by Vereczki, V., Köves, K., Csáki, A., Grósz, K., Hoffman, G.E., Fiskum, G.

“…In our present work utilizing the retrograde or anterograde transport of tracers (biotinylated dextran amine and Fluorogold, respectively) we have provided…”
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Early processing of Bid and caspase-6, -8, -10, -14 in the canine brain during cardiac arrest and resuscitation by Krajewska, Maryla, Rosenthal, Robert E., Mikolajczyk, Jowita, Stennicke, Henning R., Wiesenthal, Thomas, Mai, Juergen, Naito, Mikihiko, Salvesen, Guy S., Reed, John C., Fiskum, Gary, Krajewski, Stan

“…A clinically relevant model of transient global brain ischemia involving cardiac arrest followed by resuscitation in dogs was utilized to study the expression…”
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Postnatal brain development and neural cell differentiation modulate mitochondrial Bax and BH3 peptide-induced cytochrome c release by Polster, B M, Robertson, C L, Bucci, C J, Suzuki, M, Fiskum, G

“…Bax mediates cytochrome c release and apoptosis during neurodevelopment. Brain mitochondria that were isolated from 8-day, 17-day, and adult rats displayed…”
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Effects of L-carnitine on serum triglyceride and cytokine levels in rat models of cachexia and septic shock by WINTER, B. K, FISKUM, G, GALLO, L. L

“…Inappropriate hepatic lipogenesis, hypertriglyceridaemia, decreased fatty acid oxidation and muscle protein wasting are common in patients with sepsis, cancer…”
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GABAergic mechanism of propofol toxicity in immature neurons by Kahraman, S, Zup, SL, McCarthy, MM, Fiskum, G

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Normoxic Compared to Hyperoxic Reperfusion Improves Neurochemical and Histologic Outcome in Models of Global Cerebral Ischemia and Reperfusion Using Different Animal Species by Fiskum, G, Balan, IS, Rosenthal, RE, Kristian, T, Hazelton, JL

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Prevention of postischemic canine neurological injury through potentiation of brain energy metabolism by acetyl-L-carnitine by Rosenthal, R E, Williams, R, Bogaert, Y E, Getson, P R, Fiskum, G

“…Mechanisms of ischemia/reperfusion brain injury include altered patterns of energy metabolism that may be amenable to pharmacological manipulation. The purpose…”
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Regulation of brain mitochondrial H2O2 production by membrane potential and NAD(P)H redox state by Starkov, Anatoly A., Fiskum, Gary

“…Mitochondrial production of reactive oxygen species (ROS) at Complex I of the electron transport chain is implicated in the etiology of neural cell death in…”
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Mitochondrial mechanisms of neural cell apoptosis by Polster, Brian M., Fiskum, Gary

“…The importance of calcium overload, mitochondrial dysfunction, and free radical generation to neuropathological processes has been recognized for many years…”
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