Search Results - "Fishwild, Dianne M."

Antigen-specific human antibodies from mice comprising four distinct genetic modifications by Lonberg, Nils, Taylor, Lisa D, Harding, Fiona A, Trounstine, Mary, Higgins, Kay M, Schramm, Stephen R, Kuo, Chiung-Chi, Mashayekh, Roshanak, Wymore, Kathryn, McCabe, James G, Munoz-O'Regan, Donna, O'Donnell, Susan L, Lapachet, Elizabeth S. G, Bengoechea, Tasha, Fishwild, Dianne M, Carmack, Condie E, Kay, Robert M, Huszar, Dennis

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High-avidity human IgGκ monoclonal antibodies from a novel strain of minilocus transgenic mice by Fishwild, Dianne M, O'Donnell, Susan L, Bengoechea, Tasha, Hudson, Debra V, Harding, Fiona, Bernhard, Susan L, Jones, Debbie, Kay, Robert M, Higgins, Kay M, Schramm, Stephen R, Lonberg, Nils

“…Human immunoglobulin transgenic mice provide a method of obtaining human monoclonal antibodies (Mabs) using conventional hybridoma technology. We describe a…”
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Three-Dimensional Quantitative Structure−Activity Relationship Analysis of Ligand Binding to Human Sequence Antidigoxin Monoclonal Antibodies Using Comparative Molecular Field Analysis by Farr, Carol D, Tabet, Michael R, Ball, William J, Fishwild, Dianne M, Wang, Xia, Nair, Anil C, Welsh, William J

“…The present study indicates that the newly generated human sequence antidigoxin monoclonal antibody (mAb), 1B3, binds digoxin with a different fine specificity…”
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T Cell-targeted Immunofusion Proteins from Escherichia coli(∗) by Better, Marc, Bernhard, Susan L., Williams, Robert E., Leigh, Scott D., Bauer, Robert J., Kung, Ada H.C., Carroll, Stephen F., Fishwild, Dianne M.

“…Fusion proteins between cell-targeting domains and cytotoxic proteins should be particularly effective therapeutic reagents. We constructed a family of…”
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Efficacy of an anti-CD7-ricin A chain immunoconjugate in a novel murine model of human T-cell leukemia by FISHWILD, D. M, ABERLE, S, BERNHARD, S. L, KUNG, A. H. C

“…In vivo efficacy testing of monoclonal antibody-based drugs specific for human leukemias is hampered by the paucity of suitable animal models, due in part to…”
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Cysteine Analogs of Recombinant Barley Ribosome Inactivating Protein Form Antibody Conjugates with Enhanced Stability and Potency in vitro by Bernhard, Susan L, Better, Marc, Fishwild, Dianne M, Lane, Julie A, Orme, Ann E, Garrison, Darryl A, Birr, Cynthia A, Lei, Shau-Ping, Carroll, Stephen F

“…Antibody immunoconjugates were made with native and recombinant forms of the type-I ribosome inactivating protein from barley (BRIP) and with three recombinant…”
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Assessing the regulation of T cell function by distinct cytokine combinations using GuavaFlo, a cytometry-based system for multidimensional cellular analysis. (B206) by Gillis, Katherine Anne, Fishwild, Dianne M, Lefebvre, Ray, Zieske, Lynn R, Snyder-Cappione, Jennifer E., Cappione, Amedeo J

“…Precise regulation of effector function is critical for mounting a potent, yet specific, immune response to a given antigenic challenge. Distinct cytokine…”
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Differential Effects of Administration of a Human Anti-CD4 Monoclonal Antibody, HM6G, in Nonhuman Primates by Fishwild, Dianne M., Hudson, Debra V., Deshpande, Usha, Kung, Ada H.C.

“…A human sequence IgGκ anti-CD4 monoclonal antibody (mAb), HM6G, originally isolated from a human immunoglobulin transgenic mouse was specific for and bound…”
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Potent Anti-CD5 Ricin A Chain Immunoconjugates from Bacterially Produced Fab' and F(ab') 2 by Better, Marc, Bernhard, Susan L., Lei, Shau-Ping, Fishwild, Dianne M., Lane, Julie A., Carroll, Stephen F., Howritz, Arnold H.

“…We have used genetic engineering to obtain secretion of anti-human CD5 antibody fragments from Escherichia coli for conjugation to the 30-kDa form of ricin A…”
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Potent anti-CD5 ricin A chain immunoconjugates from bacterially produced Fab' and F(ab')(2) by Better, Marc, Bernhard, Susan L, Lei, Shau-ping, Fishwild, Dianne M

“…A study demonstrating that chimeric Fab' with one hinge cysteine residue can be produced in Escherichia coli and conjugated to the 30-kDa form of the ricin A…”
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Activity of recombinant mitogillin and mitogillin immunoconjugates by BETTER, M, BERNHARD, S. L, SHAU-PING LEI, FISHWILD, D. M, CARROLL, S. F

“…A synthetic gene for the Aspergillus protein toxin mitogillin has been synthesized and expressed in Escherichia coli. The recombinant mitogillin is a potent…”
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Gelonin analogs with engineered cysteine residues form antibody immunoconjugates with unique properties by Better, M, Bernhard, S L, Fishwild, D M, Nolan, P A, Bauer, R J, Kung, A H, Carroll, S F

“…We engineered the ribosome inactivating-protein gelonin (Gel) to generate a family of Gel analogs, each with a single unpaired cysteine residue. The cysteine…”
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Lipopolysaccharide-induced E-selectin expression requires continuous presence of LPS and is inhibited by bactericidal/permeability-increasing protein by Huang, K, Fishwild, D M, Wu, H M, Dedrick, R L

“…Endothelial cells stimulated by LPS express E-selectin, which plays an important role in mediating neutrophil adhesion during inflammation. E-selectin is…”
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Investigation and prevention of artifactual staining in flow cytometric analyses of whole blood samples from patients treated with H65-RTA, an anti-CD5 monoclonal antibody conjugated to ricin A chain by Fishwild, D M, Saria, E A

“…To assess the biological effect of therapeutic monoclonal antibodies (mAbs) immunoconjugates, flow cytometric assays are often performed on patients' blood…”
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Efficacy of an anti-CD5-ricin A chain immunoconjugate in an improved human peripheral blood lymphocyte--reconstituted severe combined immunodeficient mouse model by Kohn, F R, Fishwild, D M, Kung, A H

“…Severe combined immunodeficient mice reconstituted with human peripheral blood lymphocytes (hu-PBL-SCID mice) were used to evaluate in vivo efficacy of a mouse…”
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Efficacy of anti-CD5 F(ab')2 and Fab' immunoconjugates in human peripheral blood lymphocyte-reconstituted severe combined immunodeficient mice by Kohn, F R, Fishwild, D M, Bernhard, S L, Better, M, Kung, A H

“…A human peripheral blood lymphocyte-reconstituted severe combined immunodeficient (hu-PBL-SCID) mouse model was used to compare in vivo efficacy of…”
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Human Monoclonal Antibodies Neutralizing Varicella-Zoster Virus by Foung, Steven K. H., Perkins, Susan, Koropchak, Celine, Fishwild, Dianne M., Wittek, Alec E., Engleman, Edgar G., Grumet, F. Carl, Arvin, Ann M.

“…Hybridomas secreting human monoclonal antibodies to varicella-zoster virus were produced by fusing B cells of a patient recovering from acute varicella…”
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A subset of human rosetted lymphocytes contains previously unidentified histamine by Khan, M M, Fishwild, D M, Melmon, K L, Coutre, S, Engleman, E G, Bauer, J A

“…By sequential solid-phase immunoadsorption (panning) steps, we have isolated a subset of lymphocytes (comprising 3-7% of rosetted cells) that contains high…”
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