Search Results - "Fishwild, D M"

Potent Anti-CD5 Ricin A Chain Immunoconjugates from Bacterially Produced Fab' and F(ab') 2 by Better, Marc, Bernhard, Susan L., Lei, Shau-Ping, Fishwild, Dianne M., Lane, Julie A., Carroll, Stephen F., Howritz, Arnold H.

“…We have used genetic engineering to obtain secretion of anti-human CD5 antibody fragments from Escherichia coli for conjugation to the 30-kDa form of ricin A…”
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Differential Effects of Administration of a Human Anti-CD4 Monoclonal Antibody, HM6G, in Nonhuman Primates by Fishwild, Dianne M., Hudson, Debra V., Deshpande, Usha, Kung, Ada H.C.

“…A human sequence IgGκ anti-CD4 monoclonal antibody (mAb), HM6G, originally isolated from a human immunoglobulin transgenic mouse was specific for and bound…”
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Functional characterization of human T lymphocyte subsets distinguished by monoclonal anti-leu-8 by Kansas, GS, Wood, GS, Fishwild, DM, Engleman, EG

“…Previous studies have shown that monoclonal anti-Leu-8 antibody identifies functionally distinct subpopulations within both the Leu-2 (T8+) and Leu-3 (T4+)…”
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Activity of recombinant mitogillin and mitogillin immunoconjugates by BETTER, M, BERNHARD, S. L, SHAU-PING LEI, FISHWILD, D. M, CARROLL, S. F

“…A synthetic gene for the Aspergillus protein toxin mitogillin has been synthesized and expressed in Escherichia coli. The recombinant mitogillin is a potent…”
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Administration of an anti-CD5 immunoconjugate to patients with rheumatoid arthritis: effect on peripheral blood mononuclear cells and in vitro immune function by Fishwild, D M, Strand, V

“…An immunoconjugate, CD5 Plus, composed of ricin A chain and murine IgG1 anti-CD5 monoclonal antibody is under investigation for treatment of rheumatoid…”
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Cytotoxicity against human peripheral blood mononuclear cells and T cell lines mediated by anti‐T cell immunotoxins in the absence of added potentiator by FISHWILD, D. M., STASKAWICZ, M. O., WU, H.‐M., CARROLL, S. F.

“…SUMMARY Several in vitro assays have indicated that anti‐T cell immunotoxins (IT), composed of monoclonal antibodies (MoAbs)conjugated to ricin A chain (RTA),…”
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High-avidity human IgGκ monoclonal antibodies from a novel strain of minilocus transgenic mice by Fishwild, Dianne M, O'Donnell, Susan L, Bengoechea, Tasha, Hudson, Debra V, Harding, Fiona, Bernhard, Susan L, Jones, Debbie, Kay, Robert M, Higgins, Kay M, Schramm, Stephen R, Lonberg, Nils

“…Human immunoglobulin transgenic mice provide a method of obtaining human monoclonal antibodies (Mabs) using conventional hybridoma technology. We describe a…”
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Gelonin analogs with engineered cysteine residues form antibody immunoconjugates with unique properties by Better, M, Bernhard, S L, Fishwild, D M, Nolan, P A, Bauer, R J, Kung, A H, Carroll, S F

“…We engineered the ribosome inactivating-protein gelonin (Gel) to generate a family of Gel analogs, each with a single unpaired cysteine residue. The cysteine…”
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Activation of HLA-restricted EBV-specific cytotoxic T cells does not require CD4+ (helper) T cells or exogenous cytokines by Fishwild, DM, Benike, CJ, Engleman, EG

“…MHC-restricted, viral Ag-specific "memory" CTL are thought to play a decisive role in the defense against pathogenic viruses. However, the requirements for…”
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Immunoregulatory T cell circuits in man. Identification of a distinct T cell subpopulation of the helper/inducer lineage that amplifies the development of alloantigen-specific suppressor T cells by Damle, NK, Mohagheghpour, N, Kansas, GS, Fishwild, DM, Engleman, EG

“…Regulation of the immune response in man is dependent on interactions between cells of helper/inducer (Leu-3+/T4+) lineage and cells of suppressor/cytotoxic…”
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Efficacy of an anti-CD7-ricin A chain immunoconjugate in a novel murine model of human T-cell leukemia by FISHWILD, D. M, ABERLE, S, BERNHARD, S. L, KUNG, A. H. C

“…In vivo efficacy testing of monoclonal antibody-based drugs specific for human leukemias is hampered by the paucity of suitable animal models, due in part to…”
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Investigation and prevention of artifactual staining in flow cytometric analyses of whole blood samples from patients treated with H65-RTA, an anti-CD5 monoclonal antibody conjugated to ricin A chain by Fishwild, D M, Saria, E A

“…To assess the biological effect of therapeutic monoclonal antibodies (mAbs) immunoconjugates, flow cytometric assays are often performed on patients' blood…”
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Antigen-specific suppressor T lymphocytes in man make use of the same set of surface molecules as do cytolytic T lymphocytes: roles of Leu- 2/T8, Leu-4/T3, Leu-5/T11, LFA-1 molecules by Damle, NK, Fishwild, DM, Engleman, EG

“…When cultured with autologous antigen-primed Leu-3+ lymphoblasts, Leu-2+ cells differentiate into suppressor T cells (Ts) that specifically inhibit the…”
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Characterization of the increased cytotoxicity of gelonin anti‐T cell immunoconjugates compared with ricin A chain immunoconjugates by FISHWILD, D. M., WU, H.‐M., CARROLL, S. F., BERNHARD, S. L.

“…SUMMARY Ribosomal inactivating proteins such as gelonin (Gel) and ricin A chain (RTA) conjugated to MoAbs bind to specific target cells, and upon…”
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Effect of para substituent on rates of phenyl ring rotation in gallium complexes of para-substituted tetraphenylporphyrins by Eaton, S. S, Fishwild, D. M, Eaton, G. R

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Human Monoclonal Antibodies Neutralizing Varicella-Zoster Virus by Foung, Steven K. H., Perkins, Susan, Koropchak, Celine, Fishwild, Dianne M., Wittek, Alec E., Engleman, Edgar G., Grumet, F. Carl, Arvin, Ann M.

“…Hybridomas secreting human monoclonal antibodies to varicella-zoster virus were produced by fusing B cells of a patient recovering from acute varicella…”
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Efficacy of an anti-CD5-ricin A chain immunoconjugate in an improved human peripheral blood lymphocyte--reconstituted severe combined immunodeficient mouse model by Kohn, F R, Fishwild, D M, Kung, A H

“…Severe combined immunodeficient mice reconstituted with human peripheral blood lymphocytes (hu-PBL-SCID mice) were used to evaluate in vivo efficacy of a mouse…”
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Efficacy of anti-CD5 F(ab')2 and Fab' immunoconjugates in human peripheral blood lymphocyte-reconstituted severe combined immunodeficient mice by Kohn, F R, Fishwild, D M, Bernhard, S L, Better, M, Kung, A H

“…A human peripheral blood lymphocyte-reconstituted severe combined immunodeficient (hu-PBL-SCID) mouse model was used to compare in vivo efficacy of…”
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A recombinant amino-terminal fragment of bactericidal/permeability increasing protein (rBPI23) inhibits soluble CD14-mediated lipopolysaccharide-induced endothelial adherence for human neutrophils by Huang, K, Conlon, P J, Fishwild, D M

“…Exposure of cultured human umbilical vein endothelial cells (HUVEC) to lipopolysaccharide (LPS) or interleukin 1 (IL-1) causes increased expression of adhesion…”
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Lipopolysaccharide-induced E-selectin expression requires continuous presence of LPS and is inhibited by bactericidal/permeability-increasing protein by Huang, K, Fishwild, D M, Wu, H M, Dedrick, R L

“…Endothelial cells stimulated by LPS express E-selectin, which plays an important role in mediating neutrophil adhesion during inflammation. E-selectin is…”
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