Search Results - "Fishwick, C W G"

Molecular Genetic and Structural Modeling Studies of Staphylococcus aureus RNA Polymerase and the Fitness of Rifampin Resistance Genotypes in Relation to Clinical Prevalence by O'Neill, A J, Huovinen, T, Fishwick, C W G, Chopra, I

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Stereo‐selective inhibition of transient receptor potential TRPC5 cation channels by neuroactive steroids by Majeed, Y, Amer, MS, Agarwal, AK, McKeown, L, Porter, KE, O'Regan, DJ, Naylor, J, Fishwick, CWG, Muraki, K, Beech, DJ

“…BACKGROUND AND PURPOSE Transient receptor potential canonical 5 (TRPC5) channels are widely expressed, including in the CNS, where they potentiate fear…”
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The potential use of single‐particle electron microscopy as a tool for structure‐based inhibitor design by Rawson, S., McPhillie, M. J., Johnson, R. M., Fishwick, C. W. G., Muench, S. P.

“…Recent developments in electron microscopy (EM) have led to a step change in our ability to solve the structures of previously intractable systems, especially…”
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A combinatorial in silico and cellular approach to identify a new class of compounds that target VEGFR2 receptor tyrosine kinase activity and angiogenesis by Kankanala, J, Latham, AM, Johnson, AP, Homer‐Vanniasinkam, S, Fishwick, CWG, Ponnambalam, S

“…BACKGROUND AND PURPOSE Vascular endothelial growth factor receptor 2 (VEGFR2) is an attractive therapeutic target for the treatment of diseases such as cancer…”
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Cis‐isomerism and other chemical requirements of steroidal agonists and partial agonists acting at TRPM3 channels by Majeed, Y, Agarwal, AK, Naylor, J, Seymour, VAL, Jiang, S, Muraki, K, Fishwick, CWG, Beech, DJ

“…BACKGROUND AND PURPOSE The transient receptor potential melastatin‐3 (TRPM3) channel forms calcium‐permeable, non‐selective, cationic channels that are…”
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Indolinones and anilinophthalazines differentially target VEGF‐A‐ and basic fibroblast growth factor‐mediated responses in primary human endothelial cells by Latham, AM, Bruns, AF, Kankanala, J, Johnson, AP, Fishwick, CWG, Homer‐Vanniasinkam, S, Ponnambalam, S

“…BACKGROUND AND PURPOSE The potent pro‐angiogenic growth factors VEGF‐A and basic fibroblast growth factor (bFGF) exert their effects by binding VEGF receptor 2…”
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Derivatives of pyrimidine, phthalimide and anthranilic acid as inhibitors of human hydroxysteroid dehydrogenase AKR1C1 by Brožič, P., Cesar, J., Kovač, A., Davies, M., Johnson, A.P., Fishwick, C.W.G., Lanišnik Rižner, T., Gobec, S.

“…Human hydroxysteroid dehydrogenase (HSD) AKR1C1 is a member of the aldo-keto reductase superfamily, and it functions mainly as a 20α-HSD. It catalyzes the…”
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5068A novel methodology to improve prolonged clot lysis in diabetes by Schutt, K A, King, R A, Tiede, C, Jankowski, V, John, V, Trehan, A, Simmons, K, Ponnambalam, S, Fishwick, C W G, McPherson, M J, Tomlinson, D C, Ajjan, R A

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Analysis of mutational resistance to trimethoprim in Staphylococcus aureus by genetic and structural modelling techniques by Vickers, Anna A., Potter, Nicola J., Fishwick, Colin W. G., Chopra, Ian, O’Neill, Alex J.

“…Objectives This study sought to expand knowledge on the molecular mechanisms of mutational resistance to trimethoprim in Staphylococcus aureus, and the fitness…”
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Benzothioxalone derivatives as novel inhibitors of UDP-N-acetylglucosamine enolpyruvyl transferases (MurA and MurZ) by Miller, Keith, Dunsmore, Colin J., Leeds, Jennifer A., Patching, Simon G., Sachdeva, Meena, Blake, Katy L., Stubbings, William J., Simmons, Katie J., Henderson, Peter J. F., De Los Angeles, Joe, Fishwick, Colin W. G., Chopra, Ian

“…Objectives We sought to identify and characterize new inhibitors of MurA and MurZ, which are enzymes involved in the early stages of bacterial peptidoglycan…”
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Self-assembling β-Sheet Tape Forming Peptides by Davies, R.P.W., Aggeli, A., Beevers, A.J., Boden, N., Carrick, L.M., Fishwick, C.W.G., Mcleish, T.C.B., Nyrkova, I., Semenov, A.N.

“…Biological proteins have intrinsically the ability to self-assemble, and this has been implicated in pathological situations called amyloid diseases…”
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Abstracts of the 20th International Isotope Society (UK group) Symposium: Synthesis & Applications of Labelled Compounds 2011 by Aigbirhio, F., Appleyard, M. V. C. L., Arrowsmith, R. L., Baldwin, S. A., Bayrakdarian, M., Botting, N. P., Cantin, L. D., Carbery, D. R., Carroll, M. A., Dixon, L. I., Dorff, P. N., Ellames, G., Elmore, C. S., Fishwick, C. W. G., Foot, O., Geach, N. J., Gowdy, J., Grainger, R. S., Gregson, T., Harker, W. R. R., Henderson, P. J. F., Heys, J. R., Homans, S. W., Hu, Z., Jackson, S., Johnston, J., Johnson, P., Kalverda, A., Kay, C., Kitson, S. L., Lanoue, B., Levitt, M. H., Li, Y., Lockley, W. J. S., Luo, X, Ma, P., Middleton, D. A., Newsome, J., Pandya, B., Pascu, S. I., Patching, S. G., Phillips-Jones, M. K., Powell, M. E., Riss, P., Simmons, J., Simpson, T. M., Smith, A. D., Thompson, A. M., Trembleau, L., Turtle, R., Watters, K. W., Zhang, Q.

“…Meeting Summary The 20th annual symposium of the International Isotope Society's United Kingdom Group took place at the Wellcome Genome Campus, Hinxton,…”
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Use of synthetic oligoribonucleotides to probe RNA - protein interactions in the MS2 translational operator complex by TALBOT, S. J, GOODMAN, S, BATES, S. R. E, FISHWICK, C. W. G, STOCKLEY, P. G

“…Synthetic oligoribonucleotides have been used to probe the interaction of MS2 coat protein with the translational operator of the MS2 replicase gene. We have…”
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Two novel amino acid derivatives containing side-chain thioamides for the synthesis of photoactivatable peptides by Singh, Preeti, Hurrell, Craig R., Findlay, John B.C., Fishwick, Colin W.G.

“…The highly efficient preparation of two optically pure phenylalanine analogues containing p-N-aryl thiobenzamide moieties are described. These amino acids are…”
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Hyperreactivity of adenines and conformational flexibility of a translational repression site by Talbot, Simon J., Medina, Gloria, Fishwick, Colin W.G., Haneef, I., Stockley, Peter G.

“…We have used a diethylpyrocarbonate (DEPC) modification [(1976) Prog. Nucl. Acids Res. 16, 189–262] to probe the accessibility of adenines essential for coat…”
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Regio- and chemoselective alkylation of 2,3-dialkylindoles. A convenient preparation of 2,3,3-trialkyl-3H-indoles by FISHWICK, C. W. G, JONES, A. D, MITCHELL, M. B

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