Search Results - "Fishman, Peter H."

Filipin-Dependent Inhibition of Cholera Toxin: Evidence for Toxin Internalization and Activation through Caveolae-Like Domains by Orlandi, Palmer A., Fishman, Peter H.

“…The mechanism by which cholera toxin (CT) is internalized from the plasma membrane before its intracellular reduction and subsequent activation of adenylyl…”
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Accelerated Dephosphorylation of the β2-Adrenergic Receptor by Mutation of the C-Terminal Lysines: Effects on Ubiquitination, Intracellular Trafficking, and Degradation by Liang, Wei, Hoang, Quang, Clark, Richard B, Fishman, Peter H

“…Agonist-mediated ubiquitination regulates some G protein-coupled receptors by targeting them to lysosomes for degradation. Phosphorylation also regulates…”
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D2-like dopamine and β-adrenergic receptors form a signaling complex that integrates Gs- and Gi-mediated regulation of adenylyl cyclase by Rebois, R. Victor, Maki, Karl, Meeks, Julie A., Fishman, Peter H., Hébert, Terence E., Northup, John K.

“…β-Adrenergic receptors (βAR) and D2-like dopamine receptors (which include D2-, D3- and D4-dopamine receptors) activate Gs and Gi, the stimulatory and…”
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Differences in endosomal targeting of human β1- and β2-adrenergic receptors following clathrin-mediated endocytosis by Liang, Wei, Curran, Patricia K., Hoang, Quang, Moreland, R. Travis, Fishman, Peter H.

“…The β2-adrenergic receptor (β2AR) undergoes agonist-mediated endocytosis via clathrin-coated pits by a process dependent on both arrestins and dynamin…”
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Resistance of the Human β1-Adrenergic Receptor to Agonist-induced Ubiquitination by Liang, Wei, Fishman, Peter H.

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Complexity of Agonist- and Cyclic AMP-Mediated Downregulation of the Human β1-Adrenergic Receptor:  Role of Internalization, Degradation, and mRNA Destabilization by Dunigan, Cheryl D, Hoang, Quang, Curran, Patricia K, Fishman, Peter H

“…Prolonged agonist exposure often induces downregulation of G protein-coupled receptors (GPCRs). Although downregulation of the prototypical β2-adrenergic…”
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Protein kinase C‐mediated down‐regulation of β2‐adrenergic receptor and gene expression in rat C6 glioma cells by Leavitt, Maria, Setola, Vincent, Fishman, Peter H.

“…We investigated the regulation of β2‐adrenergic receptors (β2AR) by protein kinase C (PKC) in rat C6 glioma cells at the levels of receptor activity, protein…”
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Cholera toxin internalization and intoxication by Fishman, Peter H, Orlandi, Palmer A

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Complexity of agonist- and cyclic AMP-mediated downregulation of the human beta 1-adrenergic receptor: role of internalization, degradation, and mRNA destabilization by Dunigan, Cheryl D, Hoang, Quang, Curran, Patricia K, Fishman, Peter H

“…Prolonged agonist exposure often induces downregulation of G protein-coupled receptors (GPCRs). Although downregulation of the prototypical beta(2)-adrenergic…”
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Biosynthesis and localization of gangliosides in cultured cells by Miller-Podraza, Halina, Bradley, Roy M, Fishman, Peter H

“…Mouse neuroblastoma N18 cells contain a homologous series of gangliosides (GM3, GM2, GM1, and GD1a) which constitute a biosynthetic pathway. When added to the…”
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Translocation of newly synthesized gangliosides to the cell surface by Miller-Podraza, Halina, Fishman, Peter H

“…A new method was developed to follow the translocation of gangliosides from their site of synthesis within the cell to the plasma membrane. Cultured mouse…”
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The Heat-Labile Enterotoxin of Escherichia coli Binds to Polylactosaminoglycan-Containing Receptors in CaCo-2 Human Intestinal Epithelial Cells by Orlandi, Palmer A, Critchley, David R, Fishman, Peter H

“…The E. coli type I heat-labile enterotoxin (LT-I) shares considerable functional, structural, and immunological homology with cholera toxin (CT). Although the…”
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Brefeldin A inhibits protein synthesis in cultured cells by Fishman, Peter H., Curran, Patricia K.

“…The fungal metabolite brefeldin A (BFA) is known to disrupt the Golgi apparatus resulting in redistribution of Golgi proteins to the endoplasmic reticulum and…”
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Biosynthesis and Function of Gangliosides by Fishman, Peter H., Brady, Roscoe O.

“…Gangliosides are unique acidic glycolipids that are selectively concentrated in the plasma membrane of cells. Surface labeling studies have demonstrated that…”
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Neoglycolipid analogs of ganglioside GM1 as functional receptors of cholera toxin by Pacuszka, Tadeusz, Bradley, Roy M, Fishman, Peter H

“…We synthesized several lipid analogues of ganglioside GM1 by attaching its oligosaccharide moiety (GM1OS) to aminophospholipids, aliphatic amines, and…”
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Direct evidence that endogenous GM1 ganglioside can mediate thymocyte proliferation by SPIEGEL, F, FISHMAN, P. H, WEBER, R. J

“…The B subunit of cholera toxin, which is multivalent and binds exclusively to a specific ganglioside, GM1, was mitogenic for rat thymocytes. When exposed to…”
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Muscarinic receptor-mediated increase in cAMP levels in SK-N-SH human neuroblastoma cells by Baumgold, J, Fishman, P H

“…Stimulation of muscarinic cholinergic receptors in SK-N-SH human neuroblastoma cells resulted in a 1.5-4 fold increase in intracellular cAMP levels. This…”
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D2-like dopamine and [beta]-adrenergic receptors form a signaling complex that integrates Gs- and Gi-mediated regulation of adenylyl cyclase by Rebois, RVictor, Maki, Karl, Meeks, Julie A, Fishman, Peter H, Hebert, Terence E, Northup, John K

“…[beta]-Adrenergic receptors ([beta]AR) and D2-like dopamine receptors (which include D2-, D3- and D4-dopamine receptors) activate Gs and Gi, the stimulatory…”
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Anomalous mutarotation of glucose 6-phosphate. An example of intramolecular catalysis by Bailey, J. Martyn, Fishman, Peter H, Pentchev, Peter G

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Intoxication of cultured cells by cholera toxin: evidence for different pathways when bound to ganglioside GM1 or neoganglioproteins by Pacuszka, Tadeusz, Fishman, Peter H

“…We previously reported that when the oligosaccharide of ganglioside GM1 is covalently attached to cell surface proteins of GM1-deficient rat glioma C6 cells,…”
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