Search Results - "Fishman, P H"

Brefeldin A blocks the response of cultured cells to cholera toxin. Implications for intracellular trafficking in toxin action by ORLANDI, P. A, CURRAN, P. K, FISHMAN, P. H

“…Cholera toxin (CT) consists of a pentameric B subunit which binds to ganglioside GM1 on the cell surface and an A subunit which activates adenylylcyclase. The…”
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Gangliosides as Bimodal Regulators of Cell Growth by Spiegel, Sarah, Fishman, Peter H.

“…The B subunit of cholera toxin, which binds specifically to several molecules of ganglioside galactosyl(β 1→ 3)-N-acetylgalactosyminyl(β 1→…”
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Neuropeptide Y inhibits cardiac adenylate cyclase through a pertussis toxin-sensitive G protein by Kassis, S., Olasmaa, M., Terenius, L., Fishman, P.H.

“…Neuropeptide Y, a major neuropeptide and potent vasoconstrictor, inhibited isoproterenol-stimulated adenylate cyclase activity in cultured rat atrial cells as…”
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Filipin-Dependent Inhibition of Cholera Toxin: Evidence for Toxin Internalization and Activation through Caveolae-Like Domains by Orlandi, Palmer A., Fishman, Peter H.

“…The mechanism by which cholera toxin (CT) is internalized from the plasma membrane before its intracellular reduction and subsequent activation of adenylyl…”
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Phorbol esters and beta-adrenergic agonists mediate desensitization of adenylate cyclase in rat glioma C6 cells by distinct mechanisms by Kassis, S, Zaremba, T, Patel, J, Fishman, P H

“…Exposure of rat glioma C6 cells to either isoproterenol or 12-O-tetradecanoylphorbol 13-acetate (TPA) resulted in desensitization of isoproterenol-stimulated…”
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Orientation of cholera toxin bound to target cells by ORLANDI, P. A, FISHMAN, P. H

“…Cholera toxin (CT) consists of a pentameric B subunit that binds to specific cell surface receptors identified as ganglioside GM1 and an A subunit that…”
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Desensitization of the human beta 1-adrenergic receptor. Involvement of the cyclic AMP-dependent but not a receptor-specific protein kinase by Zhou, X M, Fishman, P H

“…Human SK-N-MC neurotumor cells express beta 1- but not beta 2-adrenergic receptors. Following exposure of the cells to isoproterenol, there was no reduction in…”
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Generation of cell surface neoganglioproteins. GM1-neoganglioproteins are non-functional receptors for cholera toxin by PACUSZKA, T, FISHMAN, P. H

“…GM1 (II3Neu5Ac-GgOse4Cer)-oligosaccharide was prepared from the ganglioside by ozonolysis and alkaline fragmentation, reductively aminated and coupled to the…”
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Differential activation of the stimulatory and inhibitory guanine nucleotide-binding proteins by fluoroaluminate in cells and in membranes by INOUE, Y, FISHMAN, P. H, REBOIS, R. V

“…Fluoroaluminate had no effect on cAMP levels in cells but inhibited agonist-stimulated cAMP accumulation. In membranes, fluoroaluminate stimulated adenylate…”
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A sensitive enzymatic assay for determination of cholesterol in lipid extracts by Omodeo Salè, F, Marchesini, S, Fishman, P H, Berra, B

“…A procedure for the determination of free and total cholesterol in lipid extracts is described. The method for free cholesterol employs cholesterol oxidase to…”
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Desensitization of the beta-adrenergic receptor-coupled adenylate cyclase in cultured mammalian cells. Receptor sequestration versus receptor function by Kassis, S, Olasmaa, M, Sullivan, M, Fishman, P H

“…Human A431 and rat glioma C6 cells exposed to isoproterenol underwent a time- and dose-dependent loss of isoproterenol-stimulated adenylate cyclase activity…”
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Direct Visualization of Redistribution and Capping of Fluorescent Gangliosides on Lymphocytes by Spiegel, Sarah, Kassis, Shouki, Wilchek, Meir, Fishman, Peter H.

“…Fluorescent derivatives of gangliosides were prepared by oxidizing the sialyl residues to aldehydes and reacting them with fluorescent hydrazides. When…”
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Ganglioside Inhibition of Fibronectin-Mediated Cell Adhesion to Collagen by Kleinman, Hynda K., Martin, George R., Fishman, Peter H.

“…Fibronectin mediates the adhesion of cells to collagen by first binding to the collagen substrate, followed by attachment of the cells to the…”
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Gangliosides modulate sodium transport in cultured toad kidney epithelia by Spiegel, S, Handler, J S, Fishman, P H

“…Cultured A6 epithelial cells from toad kidney form confluent monolayers with tight junctions separating the apical and basolateral membranes. These two…”
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Desensitization of catecholamine-stimulated adenylate cyclase and down-regulation of beta-adrenergic receptors in rat glioma C6 cells. Role of cyclic AMP and protein synthesis by Zaremba, T G, Fishman, P H

“…When exposed to the beta-agonist (-)-isoproterenol, rat glioma C6 cells exhibited a time-and concentration-dependent reduction in isoproterenol responsiveness…”
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Incorporation of Fluorescent Gangliosides into Human Fibroblasts: Mobility, Fate, and Interaction with Fibronectin by Spiegel, Sarah, Schlessinger, Joseph, Fishman, Peter H.

“…Rhodamine- and fluorescein-labeled gangliosides were used as probes to investigate the distribution, dynamics, and fate of plasma membrane-bound gangliosides…”
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Identification and characterization of functional D1 dopamine receptors in a human neuroblastoma cell line by Sidhu, A, Fishman, P H

“…Dopamine stimulated human neuroblastoma SK-N-MC cells to accumulated cyclic AMP. The D1 agonist SKF (R)-38393 also stimulated cyclic AMP production whereas the…”
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Orbital ganglioglioma arising from ectopic neural tissue by Harmon, Heather L, Gossman, M.Douglas, Buchino, John J, Eberly, Steven M, Roberts, Dale M, Fishman, Peggy H

“…PURPOSE: To report a case of neonatal orbital ganglioglioma originating from ectopic neural tissue. METHOD: Case report. RESULTS: An African-American male…”
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Intravitreal liposome-encapsulated gentamicin in a rabbit model: prolonged therapeutic levels by FISHMAN, P. H, PEYMAN, G. A, LESAR, T

“…The authors investigated the effect of liposome encapsulation on the pharmacokinetics of gentamicin after intravitreal injection in albino rabbits, using…”
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Monoclonal IgM in a patient with paraproteinemic polyneuropathy binds to gangliosides containing disialosyl groups by Ilyas, A A, Quarles, R H, Dalakas, M C, Fishman, P H, Brady, R O

“…Monoclonal IgM kappa from a patient with polyneuropathy associated with paraproteinemia was found to bind to several polysialogangliosides. Binding of IgM to…”
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