Search Results - "Fishman, Glenn I."

Connexin-43 prevents hematopoietic stem cell senescence through transfer of reactive oxygen species to bone marrow stromal cells by Ishikawa, Eri Taniguchi, Gonzalez-Nieto, Daniel, Ghiaur, Gabriel, Dunn, Susan K., Ficker, Ashley M., Murali, Bhuvana, Madhu, Malav, Gutstein, David E., Fishman, Glenn I., Barrio, Luis C., Cancelas, Jose A.

“…Hematopoietic stem cell (HSC) aging has become a concern in chemotherapy of older patients. Humoral and paracrine signals from the bone marrow (BM)…”
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Genetically engineered SCN5A mutant pig hearts exhibit conduction defects and arrhythmias by Park, David S, Cerrone, Marina, Morley, Gregory, Vasquez, Carolina, Fowler, Steven, Liu, Nian, Bernstein, Scott A, Liu, Fang-Yu, Zhang, Jie, Rogers, Christopher S, Priori, Silvia G, Chinitz, Larry A, Fishman, Glenn I

“…SCN5A encodes the α subunit of the major cardiac sodium channel Na(V)1.5. Mutations in SCN5A are associated with conduction disease and ventricular…”
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Ephaptic Conduction in a Cardiac Strand Model with 3D Electrodiffusion by Mori, Yoichiro, Fishman, Glenn I., Peskin, Charles S.

“…We study cardiac action potential propagation under severe reduction in gap junction conductance. We use a mathematical model of cellular electrical activity…”
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Scn1b deletion leads to increased tetrodotoxin‐sensitive sodium current, altered intracellular calcium homeostasis and arrhythmias in murine hearts by Lin, Xianming, O'Malley, Heather, Chen, Chunling, Auerbach, David, Foster, Monique, Shekhar, Akshay, Zhang, Mingliang, Coetzee, William, Jalife, José, Fishman, Glenn I., Isom, Lori, Delmar, Mario

“…Key points Na+ current (INa) results from the integrated function of a molecular aggregate (the voltage‐gated Na+ channel complex) that includes the β subunit…”
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Fhf2 gene deletion causes temperature-sensitive cardiac conduction failure by Park, David S., Shekhar, Akshay, Marra, Christopher, Lin, Xianming, Vasquez, Carolina, Solinas, Sergio, Kelley, Kevin, Morley, Gregory, Goldfarb, Mitchell, Fishman, Glenn I.

“…Fever is a highly conserved systemic response to infection dating back over 600 million years. Although conferring a survival benefit, fever can negatively…”
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Phosphatase-Resistant Gap Junctions Inhibit Pathological Remodeling and Prevent Arrhythmias by Remo, Benjamin F, Qu, Jiaxiang, Volpicelli, Frank M, Giovannone, Steven, Shin, Daniel, Lader, Joshua, Liu, Fang-yu, Zhang, Jie, Lent, Danielle S, Morley, Gregory E, Fishman, Glenn I

“…RATIONALE:Posttranslational phosphorylation of connexin43 (Cx43) has been proposed as a key regulatory event in normal cardiac gap junction expression and…”
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Myocardial Notch Signaling Reprograms Cardiomyocytes to a Conduction-Like Phenotype by RENTSCHLER, Stacey, YEN, Alberta H, JIA LU, PETRENKO, Nataliya B, MIN MIN LU, MANDERFIELD, Lauren J, PATEL, Vickas V, FISHMAN, Glenn I, EPSTEIN, Jonathan A

“…Notch signaling has previously been shown to play an essential role in regulating cell fate decisions and differentiation during cardiogenesis in many systems…”
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Subcellular heterogeneity of sodium current properties in adult cardiac ventricular myocytes by Lin, Xianming, PhD, Liu, Nian, MD, Lu, Jia, PhD, Zhang, Jie, BS, Anumonwo, Justus M.B., PhD, Isom, Lori L., PhD, Fishman, Glenn I., MD, Delmar, Mario, MD, PhD

“…Background Sodium channel α-subunits in ventricular myocytes (VMs) segregate either to the intercalated disc or to lateral membranes, where they associate with…”
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Nav-igating through a complex landscape: SCN10A and cardiac conduction by Park, David S, Fishman, Glenn I

“…Genome-wide association studies (GWAS) have implicated SCN10A, which encodes a nociceptor-associated voltage-gated sodium channel subunit, as a modulator of…”
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Connexin-43 in the osteogenic BM niche regulates its cellular composition and the bidirectional traffic of hematopoietic stem cells and progenitors by Gonzalez-Nieto, Daniel, Li, Lina, Kohler, Anja, Ghiaur, Gabriel, Ishikawa, Eri, Sengupta, Amitava, Madhu, Malav, Arnett, Jorden L., Santho, Rebecca A., Dunn, Susan K., Fishman, Glenn I., Gutstein, David E., Civitelli, Roberto, Barrio, Luis C., Gunzer, Matthias, Cancelas, Jose A.

“…Connexin-43 (Cx43), a gap junction protein involved in control of cell proliferation, differentiation and migration, has been suggested to have a role in…”
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The severity of mammary gland developmental defects is linked to the overall functional status of Cx43 as revealed by genetically modified mice by Stewart, Michael K G, Gong, Xiang-Qun, Barr, Kevin J, Bai, Donglin, Fishman, Glenn I, Laird, Dale W

“…Genetically modified mice mimicking ODDD (oculodentodigital dysplasia), a disease characterized by reduced Cx43 (connexin 43)-mediated gap junctional…”
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Purkinje Cells From RyR2 Mutant Mice Are Highly Arrhythmogenic But Responsive to Targeted Therapy by Kang, Guoxin, Giovannone, Steven F, Liu, Nian, Liu, Fang-Yu, Zhang, Jie, Priori, Silvia G, Fishman, Glenn I

“…RATIONALEThe Purkinje fiber network has been proposed as the source of arrhythmogenic Ca release events in catecholaminergic polymorphic ventricular…”
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Proliferation of Adult Sertoli Cells Following Conditional Knockout of the Gap Junctional Protein GJA1 (Connexin 43) in Mice by Sridharan, Santhi, Simon, Liz, Meling, Daryl D, Cyr, Daniel G, Gutstein, David E, Fishman, Glenn I, Guillou, Florian, Cooke, Paul S

“…GJA1 (also known and referred to here as connexin 43 and abbreviated CX43) is the predominant testicular gap junction protein, and CX43 may regulate Sertoli…”
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Efficient Generation of Cardiac Purkinje Cells from ESCs by Activating cAMP Signaling by Tsai, Su-Yi, Maass, Karen, Lu, Jia, Fishman, Glenn I., Chen, Shuibing, Evans, Todd

“…Dysfunction of the specialized cardiac conduction system (CCS) is associated with life-threatening arrhythmias. Strategies to derive CCS cells, including rare…”
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Myogenic bladder defects in mouse models of human oculodentodigital dysplasia by Huang, Tao, Shao, Qing, Barr, Kevin, Simek, Jamie, Fishman, Glenn I, Laird, Dale W

“…To date, over 65 mutations in the gene encoding Cx43 (connexin43) have been linked to the autosomal-dominant disease ODDD (oculodentodigital dysplasia). A…”
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Identification and purification of human induced pluripotent stem cell-derived atrial-like cardiomyocytes based on sarcolipin expression by Josowitz, Rebecca, Lu, Jia, Falce, Christine, D'Souza, Sunita L, Wu, Meng, Cohen, Ninette, Dubois, Nicole C, Zhao, Yong, Sobie, Eric A, Fishman, Glenn I, Gelb, Bruce D

“…The use of human stem cell-derived cardiomyocytes to study atrial biology and disease has been restricted by the lack of a reliable method for stem…”
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Regulation of Peroxisome Proliferator-Activated Receptor γ Coactivator 1α (PGC-1α) and Mitochondrial Function by MEF2 and HDAC5 by Czubryt, Michael P., McAnally, John, Fishman, Glenn I., Olson, Eric N.

“…The myocyte enhancer factor-2 (MEF2) transcription factor regulates muscle development and calcium-dependent gene expression. MEF2 activity is repressed by…”
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Contactin-2 Expression in the Cardiac Purkinje Fiber Network by Pallante, Benedetta A, Giovannone, Steven, Fang-Yu, Liu, Zhang, Jie, Liu, Nian, Kang, Guoxin, Dun, Wen, Boyden, Penelope A, Fishman, Glenn I

“…BACKGROUND—Purkinje cells (PCs) comprise the most distal component of the cardiac conduction system, and their unique electrophysiological properties and the…”
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Gap junction remodeling and cardiac arrhythmogenesis in a murine model of oculodentodigital dysplasia by Kalcheva, Nellie, Qu, Jiaxiang, Sandeep, Nefthi, Garcia, Luis, Zhang, Jie, Wang, Zhiyong, Lampe, Paul D, Suadicani, Sylvia O, Spray, David C, Fishman, Glenn I

“…Gap junction channels are required for normal cardiac impulse propagation, and gap junction remodeling is associated with enhanced arrhythmic risk…”
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Gap Junction Remodeling and Spironolactone-Dependent Reverse Remodeling in the Hypertrophied Heart by Qu, Jiaxiang, Volpicelli, Frank M, Garcia, Luis I, Sandeep, Nefthi, Zhang, Jie, Márquez-Rosado, Lucrecia, Lampe, Paul D, Fishman, Glenn I

“…Pressure overload is a common pathological insult to the heart and the resulting hypertrophy is an independent risk factor for sudden cardiac death. Gap…”
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