Search Results - "Fishman, C"

Power of rare diseases: found in translation by Fishman, Mark C

“…Aside from established genetic evidence, the best proof of a model for disease pathogenesis rests on predicted perturbation via targeted medicines in clinical…”
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Image-guided Microinvasive Percutaneous Treatment of Breast Lesions: Where Do We Stand? by Roknsharifi, Shima, Wattamwar, Kapil, Fishman, Michael D. C., Ward, Robert C., Ford, Kelly, Faintuch, Salomao, Joshi, Surekha, Dialani, Vandana

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Social determinants of health and the prediction of missed breast imaging appointments by Sotudian, Shahabeddin, Afran, Aaron, LeBedis, Christina A, Rives, Anna F, Paschalidis, Ioannis Ch, Fishman, Michael D. C

“…Abstract Background Predictive models utilizing social determinants of health (SDH), demographic data, and local weather data were trained to predict missed…”
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The mediator complex subunit Med10 regulates heart valve formation in zebrafish by controlling Tbx2b-mediated Has2 expression and cardiac jelly formation by Just, Steffen, Hirth, Sofia, Berger, Ina M., Fishman, Mark C., Rottbauer, Wolfgang

“…In search for novel key regulators of cardiac valve formation, we isolated the zebrafish cardiac valve mutant ping pong (png). We find that an insertional…”
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The heartstrings mutation in zebrafish causes heart/fin Tbx5 deficiency syndrome by Garrity, Deborah M, Childs, Sarah, Fishman, Mark C

“…Holt-Oram syndrome is one of the autosomal dominant human ‘heart-hand’ disorders, with a combination of upper limb malformations and cardiac defects…”
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Zebrafish: The Canonical Vertebrate by Fishman, Mark C.

“…The zebrafish is a dream system for scientists riding the next wave of genome-wide exploration. This photogenic creature is the first vertebrate that has…”
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Semaphorin-Plexin Signaling Guides Patterning of the Developing Vasculature by Torres-Vázquez, Jesús, Gitler, Aaron D, Fraser, Sherri D, Berk, Jason D, Van N. Pham, Fishman, Mark C, Childs, Sarah, Epstein, Jonathan A, Weinstein, Brant M

“…Major vessels of the vertebrate circulatory system display evolutionarily conserved and reproducible anatomy, but the cues guiding this stereotypic patterning…”
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αKlotho Regulates Age-Associated Vascular Calcification and Lifespan in Zebrafish by Singh, Ajeet Pratap, Sosa, Maria X., Fang, Jian, Shanmukhappa, Shiva Kumar, Hubaud, Alexis, Fawcett, Caroline H., Molind, Gregory J., Tsai, Tingwei, Capodieci, Paola, Wetzel, Kristie, Sanchez, Ellen, Wang, Guangliang, Coble, Matthew, Tang, Wenlong, Cadena, Samuel M., Fishman, Mark C., Glass, David J.

“…The hormone αKlotho regulates lifespan in mice, as knockouts die early of what appears to be accelerated aging due to hyperphosphatemia and soft tissue…”
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The myosin-interacting protein SMYD1 is essential for sarcomere organization by Just, Steffen, Meder, Benjamin, Berger, Ina M, Etard, Christelle, Trano, Nicole, Patzel, Eva, Hassel, David, Marquart, Sabine, Dahme, Tillman, Vogel, Britta, Fishman, Mark C, Katus, Hugo A, Strähle, Uwe, Rottbauer, Wolfgang

“…Assembly, maintenance and renewal of sarcomeres require highly organized and balanced folding, transport, modification and degradation of sarcomeric proteins…”
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Patterning of angiogenesis in the zebrafish embryo by Childs, Sarah, Chen, Jau-Nian, Garrity, Deborah M, Fishman, Mark C

“…Little is known about how vascular patterns are generated in the embryo. The vasculature of the zebrafish trunk has an extremely regular pattern. One…”
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Genetic Control of Collective Behavior in Zebrafish by Tang, Wenlong, Davidson, Jacob D., Zhang, Guoqiang, Conen, Katherine E., Fang, Jian, Serluca, Fabrizio, Li, Jingyao, Xiong, Xiaorui, Coble, Matthew, Tsai, Tingwei, Molind, Gregory, Fawcett, Caroline H., Sanchez, Ellen, Zhu, Peixin, Couzin, Iain D., Fishman, Mark C.

“…Many animals, including humans, have evolved to live and move in groups. In humans, disrupted social interactions are a fundamental feature of many psychiatric…”
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Collective behavior emerges from genetically controlled simple behavioral motifs in zebrafish by Harpaz, Roy, Aspiras, Ariel C, Chambule, Sydney, Tseng, Sierra, Bind, Marie-Abèle, Engert, Florian, Fishman, Mark C, Bahl, Armin

“…It is not understood how changes in the genetic makeup of individuals alter the behavior of groups of animals. Here, we find that, even at early larval stages,…”
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Gridlock, an HLH Gene Required for Assembly of the Aorta in Zebrafish by Zhong, Tao P., Rosenberg, Michael, Manzoor-Ali P. K. Mohideen, Weinstein, Brant, Fishman, Mark C.

“…The first artery and vein of the vertebrate embryo assemble in the trunk by migration and coalescence of angioblasts to form endothelial tubes. The gridlock…”
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Integrin-linked kinase, a novel component of the cardiac mechanical stretch sensor, controls contractility in the zebrafish heart by Bendig, Garnet, Grimmler, Matthias, Huttner, Inken G, Wessels, Georgia, Dahme, Tillman, Just, Steffen, Trano, Nicole, Katus, Hugo A, Fishman, Mark C, Rottbauer, Wolfgang

“…The vertebrate heart possesses autoregulatory mechanisms enabling it first to sense and then to adapt its force of contraction to continually changing demands…”
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Chemical suppression of a genetic mutation in a zebrafish model of aortic coarctation by Peterson, Randall T, Shaw, Stanley Y, Peterson, Travis A, Milan, David J, Zhong, Tao P, Schreiber, Stuart L, MacRae, Calum A, Fishman, Mark C

“…Conventional drug discovery approaches require a priori selection of an appropriate molecular target, but it is often not obvious which biological pathways…”
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FROM ZEBRAFISH TO HUMAN: Modular Medical Models by Shin, Jordan T, Fishman, Mark C

“…Genetic screens in Drosophila melanogaster , Caenorhabditis elegans , and Danio rerio clarified the logic of metazoan development by revealing critical unitary…”
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Gridlock signalling pathway fashions the first embryonic artery by Fishman, Mark C, Zhong, Tao P, Childs, Sarah, Leu, James P

“…Arteries and veins are morphologically, functionally and molecularly very different, but how this distinction is established during vasculogenesis is unknown…”
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heart of glass Regulates the Concentric Growth of the Heart in Zebrafish by Mably, John D, Burns, C.Geoffrey, Chen, Jau-Nian, Fishman, Mark C, Mohideen, Manzoor-Ali P.K

“…Background: Patterned growth of vertebrate organs is essential for normal physiological function, but the underlying pathways that govern organotypic growth…”
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Disruption of acvrl1 increases endothelial cell number in zebrafish cranial vessels by Roman, Beth L, Pham, Van N, Lawson, Nathan D, Kulik, Magdalena, Childs, Sarah, Lekven, Arne C, Garrity, Deborah M, Moon, Randall T, Fishman, Mark C, Lechleider, Robert J, Weinstein, Brant M

“…The zebrafish mutant violet beauregarde ( vbg ) can be identified at two days post-fertilization by an abnormal circulation pattern in which most blood cells…”
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Semaphorin III is needed for normal patterning and growth of nerves, bones and heart by Behar, Oded, Golden, Jeffrey A, Mashimo, Hiroshi, Schoen, Frederick J, Fishman, Mark C

“…The expression patterns of the recently discovered family of semaphorin genes suggests that they have widespread roles in embryonic development. Some seem to…”
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