Eosinophils in human oral squamous carcinoma; role of prostaglandin D2

Eosinophils in human oral squamous carcinoma; role of prostaglandin D2

Eosinophils are often predominant inflammatory leukocytes infiltrating oral squamous carcinoma (OSC) sites. Prostaglandins are secreted by oral carcinomas and may be involved in eosinophil infiltration. The objective of this study was to determine the factors contributing to eosinophil migration and...

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Bibliographic Details
Published in:Journal of inflammation (London, England) Vol. 10; no. 1; p. 4
Main Authors: Davoine, Francis, Sim, Adrian, Tang, Charlie, Fisher, Sibina, Ethier, Caroline, Puttagunta, Lakshmi, Wu, Yingqi, McGaw, W Tim, Yu, Donald, Cameron, Lisa, Adamko, Darryl J, Moqbel, Redwan
Format: Journal Article
Language:English
Published: England BioMed Central Ltd 31-01-2013
BioMed Central
Subjects:
Acquisitions & mergers
Colleges & universities
Cytotoxicity
Erythropoietin
Medical equipment and supplies industry
Medical research
Medical test kit industry
Oral cancer
Prostaglandins
Proteins
Squamous cell carcinoma
Canada
United States
Ontario Canada
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Summary:Eosinophils are often predominant inflammatory leukocytes infiltrating oral squamous carcinoma (OSC) sites. Prostaglandins are secreted by oral carcinomas and may be involved in eosinophil infiltration. The objective of this study was to determine the factors contributing to eosinophil migration and potential anti-neoplastic effects on OSC. Eosinophil degranulation was evaluated by measuring release of eosinophil peroxidase (EPO). Eosinophil chemotaxis towards OSC cells was assessed using artificial basement membrane. Eosinophil infiltration was prominent within the tissue surrounding the OSC tumor mass. We observed growth inhibition of the OSC cell line, SCC-9, during co-culture with human eosinophils, in vitro, which correlated with EPO activity that possesses growth inhibitory activity. The PGD2 synthase inhibitor, HQL-79, abrogated migration towards SCC-9. Our data suggest that OSC-derived PGD2 may play an important role via CRTH2 (the PGD2 receptor on eosinophils) in eosinophil recruitment and subsequent anti-tumor activity through the action of eosinophil cationic proteins.
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ISSN:1476-9255
1476-9255
DOI:10.1186/1476-9255-10-4