Search Results - "Fisher, Oriana S"

Signaling pathways and the cerebral cavernous malformations proteins: lessons from structural biology by Fisher, Oriana S, Boggon, Titus J

“…Cerebral cavernous malformations (CCM) are neurovascular dysplasias that result in mulberry-shaped lesions predominantly located in brain and spinal tissues…”
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Cerebral cavernous malformation proteins at a glance by Draheim, Kyle M, Fisher, Oriana S, Boggon, Titus J, Calderwood, David A

“…Loss-of-function mutations in genes encoding KRIT1 (also known as CCM1), CCM2 (also known as OSM and malcavernin) or PDCD10 (also known as CCM3) cause cerebral…”
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Comprehensive profiling of the STE20 kinase family defines features essential for selective substrate targeting and signaling output by Miller, Chad J, Lou, Hua Jane, Simpson, Craig, van de Kooij, Bert, Ha, Byung Hak, Fisher, Oriana S, Pirman, Natasha L, Boggon, Titus J, Rinehart, Jesse, Yaffe, Michael B, Linding, Rune, Turk, Benjamin E

“…Specificity within protein kinase signaling cascades is determined by direct and indirect interactions between kinases and their substrates. While the impact…”
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Structure and vascular function of MEKK3–cerebral cavernous malformations 2 complex by Fisher, Oriana S., Deng, Hanqiang, Liu, Dou, Zhang, Ya, Wei, Rong, Deng, Yong, Zhang, Fan, Louvi, Angeliki, Turk, Benjamin E., Boggon, Titus J., Su, Bing

“…Cerebral cavernous malformations 2 (CCM2) loss is associated with the familial form of CCM disease. The protein kinase MEKK3 (MAP3K3) is essential for…”
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Characterization of a long overlooked copper protein from methane- and ammonia-oxidizing bacteria by Fisher, Oriana S., Kenney, Grace E., Ross, Matthew O., Ro, Soo Y., Lemma, Betelehem E., Batelu, Sharon, Thomas, Paul M., Sosnowski, Victoria C., DeHart, Caroline J., Kelleher, Neil L., Stemmler, Timothy L., Hoffman, Brian M., Rosenzweig, Amy C.

“…Methane-oxidizing microbes catalyze the oxidation of the greenhouse gas methane using the copper-dependent enzyme particulate methane monooxygenase (pMMO)…”
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Structural studies of cerebral cavernous malformations 2 (CCM2) reveal a folded helical domain at its C-terminus by Fisher, Oriana S., Zhang, Rong, Li, Xiaofeng, Murphy, James W., Demeler, Borries, Boggon, Titus J.

“…► Limited proteolysis reveals a C-terminal domain in CCM2. ► The 1.9Å crystal structure of the CCM2 C-terminal domain is determined. ► CCM2 C-terminal domain…”
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Orchestrating copper binding: structure and variations on the cupredoxin fold by Guo, Jing, Fisher, Oriana S.

“…A large number of copper binding proteins coordinate metal ions using a shared three-dimensional fold called the cupredoxin domain. This domain was originally…”
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Caspase-1 causes truncation and aggregation of the Parkinson’s disease-associated protein α-synuclein by Wang, Wei, Nguyen, Linh T. T., Burlak, Christopher, Chegini, Fariba, Guo, Feng, Chataway, Tim, Ju, Shulin, Fisher, Oriana S., Miller, David W., Datta, Debajyoti, Wu, Fang, Wu, Chun-Xiang, Landeru, Anuradha, Wells, James A., Cookson, Mark R., Boxer, Matthew B., Thomas, Craig J., Gai, Wei Ping, Ringe, Dagmar, Petsko, Gregory A., Hoang, Quyen Q.

“…The aggregation of α-synuclein (aSyn) leading to the formation of Lewy bodies is the defining pathological hallmark of Parkinson’s disease (PD). Rare familial…”
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Stabilization of a Cu-binding site by a highly conserved tryptophan residue by de Oliveira Silva, Yuri Rafael, Zheng, Dia, Peters, Stephen C., Fisher, Oriana S.

“…Copper serves as an essential cofactor for nearly all living organisms. There are still many gaps remaining in our knowledge of how Gram-positive bacteria…”
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Structural Studies of Copper‐Binding Proteins Encoded by the ycnOperon from Bacillus subtilis by Fisher, Oriana S., Guo, Jing, Singh, Aarshi N., Damle, Madhura S., Szalai, Veronika, Peters, Stephen C.

“…Most living organisms encode an ensemble of protein transporters and chaperones to regulate copper levels. The ycn operon of the bacterium Bacillus subtilisis…”
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The YcnI protein from Bacillus subtilis contains a copper-binding domain by Damle, Madhura S., Singh, Aarshi N., Peters, Stephen C., Szalai, Veronika A., Fisher, Oriana S.

“…Bacteria require a precise balance of copper ions to ensure that essential cuproproteins are fully metalated while also avoiding copper-induced toxicity. The…”
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Crystallographic Studies of the Cerebral Cavernous Malformations Proteins by Fisher, Oriana S, Li, Xiaofeng, Liu, Weizhi, Zhang, Rong, Boggon, Titus J

“…Cerebral cavernous malformations (CCM) are dysplasias that primarily occur in the neurovasculature, and are associated with mutations in three genes: KRIT1,…”
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CCM2-CCM3 interaction stabilizes their protein expression and permits endothelial network formation by Draheim, Kyle M, Li, Xiaofeng, Zhang, Rong, Fisher, Oriana S, Villari, Giulia, Boggon, Titus J, Calderwood, David A

“…Mutations in the essential adaptor proteins CCM2 or CCM3 lead to cerebral cavernous malformations (CCM), vascular lesions that most frequently occur in the…”
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PCuAC domains from methane-oxidizing bacteria use a histidine brace to bind copper by Fisher, Oriana S., Sendzik, Madison R., Ross, Matthew O., Lawton, Thomas J., Hoffman, Brian M., Rosenzweig, Amy C.

“…Copper is critically important for methanotrophic bacteria because their primary metabolic enzyme, particulate methane monooxygenase (pMMO), is…”
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Formation and Electronic Structure of an Atypical CuA Site by Ross, Matthew O, Fisher, Oriana S, Morgada, Marcos N, Krzyaniak, Matthew D, Wasielewski, Michael R, Vila, Alejandro J, Hoffman, Brian M, Rosenzweig, Amy C

“…PmoD, a recently discovered protein from methane-oxidizing bacteria, forms a homodimer with a dicopper CuA center at the dimer interface. Although the optical…”
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Structural Basis for the Disruption of the Cerebral Cavernous Malformations 2 (CCM2) Interaction with Krev Interaction Trapped 1 (KRIT1) by Disease-associated Mutations by Fisher, Oriana S., Liu, Weizhi, Zhang, Rong, Stiegler, Amy L., Ghedia, Sondhya, Weber, James L., Boggon, Titus J.

“…Familial cerebral cavernous malformations (CCMs) are predominantly neurovascular lesions and are associated with mutations within the KRIT1, CCM2, and PDCD10…”
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The cerebral cavernous malformations proteins by Li, Xiaofeng, Fisher, Oriana S, Boggon, Titus J

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Formation and Electronic Structure of an Atypical Cu A Site by Ross, Matthew O, Fisher, Oriana S, Morgada, Marcos N, Krzyaniak, Matthew D, Wasielewski, Michael R, Vila, Alejandro J, Hoffman, Brian M, Rosenzweig, Amy C

“…PmoD, a recently discovered protein from methane-oxidizing bacteria, forms a homodimer with a dicopper Cu center at the dimer interface. Although the optical…”
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Structural characterization of a metal transporter from Bacillus subtilis by Zheng, Dia, Silva, Yuri, Fisher, Oriana S.

“…Abstract only…”
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Structural Studies of Copper‐Binding Proteins Encoded by the ycn Operon from Bacillus subtilis by Fisher, Oriana S., Guo, Jing, Singh, Aarshi N., Damle, Madhura S., Szalai, Veronika, Peters, Stephen C.

“…Abstract only Most living organisms encode an ensemble of protein transporters and chaperones to regulate copper levels. The ycn operon of the bacterium…”
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