Search Results - "Fisher, Natalie"

MmCMS: mouse models’ consensus molecular subtypes of colorectal cancer by Amirkhah, Raheleh, Gilroy, Kathryn, Malla, Sudhir B., Lannagan, Tamsin R. M., Byrne, Ryan M., Fisher, Natalie C., Corry, Shania M., Mohamed, Noha-Ehssan, Naderi-Meshkin, Hojjat, Mills, Megan L., Campbell, Andrew D., Ridgway, Rachel A., Ahmaderaghi, Baharak, Murray, Richard, Llergo, Antoni Berenguer, Sanz-Pamplona, Rebeca, Villanueva, Alberto, Batlle, Eduard, Salazar, Ramon, Lawler, Mark, Sansom, Owen J., Dunne, Philip D.

“…Background Colorectal cancer (CRC) primary tumours are molecularly classified into four consensus molecular subtypes (CMS1–4). Genetically engineered mouse…”
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Comment on “Identification of EMT-related high-risk stage II colorectal cancer and characterisation of metastasis-related genes” by Loughrey, Maurice B., Fisher, Natalie C., McCooey, Aoife J., Dunne, Philip D.

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Development of a semi‐automated method for tumour budding assessment in colorectal cancer and comparison with manual methods by Fisher, Natalie C, Loughrey, Maurice B, Coleman, Helen G, Gelbard, Melvin D, Bankhead, Peter, Dunne, Philip D

“…Aims Tumour budding (TB) is an established prognostic feature in multiple cancers but is not routinely assessed in pathology practice. Efforts to standardise…”
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The adaptive immune and immune checkpoint landscape of neoadjuvant treated esophageal adenocarcinoma using digital pathology quantitation by Humphries, Matthew P, Craig, Stephanie G, Kacprzyk, Rafal, Fisher, Natalie C, Bingham, Victoria, McQuaid, Stephen, Murray, Graeme I, McManus, Damian, Turkington, Richard C, James, Jacqueline, Salto-Tellez, Manuel

“…Limited studies examine the immune landscape in Esophageal Adenocarcinoma (EAC). We aim to identify novel associations, which may inform immunotherapy…”
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Biological Misinterpretation of Transcriptional Signatures in Tumor Samples Can Unknowingly Undermine Mechanistic Understanding and Faithful Alignment with Preclinical Data by Fisher, Natalie C, Byrne, Ryan M, Leslie, Holly, Wood, Colin, Legrini, Assya, Cameron, Andrew J, Ahmaderaghi, Baharak, Corry, Shania M, Malla, Sudhir B, Amirkhah, Raheleh, McCooey, Aoife J, Rogan, Emily, Redmond, Keara L, Sakhnevych, Svetlana, Domingo, Enric, Jackson, James, Loughrey, Maurice B, Leedham, Simon, Maughan, Tim, Lawler, Mark, Sansom, Owen J, Lamrock, Felicity, Koelzer, Viktor H, Jamieson, Nigel B, Dunne, Philip D

“…Precise mechanism-based gene expression signatures (GES) have been developed in appropriate in vitro and in vivo model systems, to identify important…”
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Effective public health messaging for university students: lessons learned to increase adherence to safety guidelines during a pandemic by Milich, Krista M., Fisher, Natalie, Sobral, Gisela

“…Variation in compliance with recommended safety behaviors early in the COVID-19 pandemic was especially concerning in places where people aggregated after…”
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Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features by Flanagan, Dustin J., Amirkhah, Raheleh, Vincent, David F., Gunduz, Nuray, Gentaz, Pauline, Cammareri, Patrizia, McCooey, Aoife J., McCorry, Amy M. B., Fisher, Natalie C., Davis, Hayley L., Ridgway, Rachel A., Lohuis, Jeroen, Leach, Joshua D. G., Jackstadt, Rene, Gilroy, Kathryn, Mariella, Elisa, Nixon, Colin, Clark, William, Hedley, Ann, Markert, Elke K., Strathdee, Douglas, Bartholin, Laurent, Redmond, Keara L., Kerr, Emma M., Longley, Daniel B., Ginty, Fiona, Cho, Sanghee, Coleman, Helen G., Loughrey, Maurice B., Bardelli, Alberto, Maughan, Timothy S., Campbell, Andrew D., Lawler, Mark, Leedham, Simon J., Barry, Simon T., Inman, Gareth J., van Rheenen, Jacco, Dunne, Philip D., Sansom, Owen J.

“…The pro-tumourigenic role of epithelial TGFβ signalling in colorectal cancer (CRC) is controversial. Here, we identify a cohort of born to be bad early-stage…”
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Author Correction: Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features by Flanagan, Dustin J., Amirkhah, Raheleh, Vincent, David F., Gunduz, Nuray, Gentaz, Pauline, Cammareri, Patrizia, McCooey, Aoife J., McCorry, Amy M. B., Fisher, Natalie C., Davis, Hayley L., Ridgway, Rachel A., Lohuis, Jeroen, Leach, Joshua D. G., Jackstadt, Rene, Gilroy, Kathryn, Mariella, Elisa, Nixon, Colin, Clark, William, Hedley, Ann, Markert, Elke K., Strathdee, Douglas, Bartholin, Laurent, Redmond, Keara L., Kerr, Emma M., Longley, Daniel B., Ginty, Fiona, Cho, Sanghee, Coleman, Helen G., Loughrey, Maurice B., Bardelli, Alberto, Maughan, Timothy S., Campbell, Andrew D., Lawler, Mark, Leedham, Simon J., Barry, Simon T., Inman, Gareth J., van Rheenen, Jacco, Dunne, Philip D., Sansom, Owen J.

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Activation of innate-adaptive immune machinery by poly(I:C) exposes a therapeutic vulnerability to prevent relapse in stroma-rich colon cancer by Corry, Shania M, McCorry, Amy Mb, Lannagan, Tamsin Rm, Leonard, Niamh A, Fisher, Natalie C, Byrne, Ryan M, Tsantoulis, Petros, Cortes-Lavaud, Xabier, Amirkhah, Raheleh, Redmond, Keara L, McCooey, Aoife J, Malla, Sudhir B, Rogan, Emily, Sakhnevych, Svetlana, Gillespie, Michael A, White, Mark, Richman, Susan D, Jackstadt, Rene-Filip, Campbell, Andrew D, Maguire, Sarah, McDade, Simon S, Longley, Daniel B, Loughrey, Maurice B, Coleman, Helen G, Kerr, Emma M, Tejpar, Sabine, Maughan, Timothy, Leedham, Simon J, Small, Donna M, Ryan, Aideen E, Sansom, Owen J, Lawler, Mark, Dunne, Philip D

“…Stroma-rich tumours represent a poor prognostic subtype in stage II/III colon cancer (CC), with high relapse rates and limited response to standard adjuvant…”
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The BH3 Mimetic Obatoclax Accumulates in Lysosomes and Causes Their Alkalinization by Stamelos, Vasileios A, Fisher, Natalie, Bamrah, Harnoor, Voisey, Carolyn, Price, Joshua C, Farrell, William E, Redman, Charles W, Richardson, Alan

“…Obatoclax belongs to a class of compounds known as BH3 mimetics which function as antagonists of Bcl-2 family apoptosis regulators. It has undergone extensive…”
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The Potential of Digital Image Analysis to Determine Tumor Cell Content in Biobanked Formalin-Fixed, Paraffin-Embedded Tissue Samples by Greene, Christine, O'Doherty, Edwina, Abdullahi Sidi, Fatima, Bingham, Victoria, Fisher, Natalie C, Humphries, Matthew P, Craig, Stephanie G, Harewood, Louise, McQuaid, Stephen, Lewis, Claire, James, Jacqueline

“…Best practices dictate that biobanks ensure accurate determination of tumor content before supplying formalin-fixed, paraffin-embedded (FFPE) tissue samples to…”
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Patient knowledge about disease self-management in cirrhosis by Volk, Michael L, Fisher, Natalie, Fontana, Robert J

“…We aimed to understand and improve patient knowledge about self-management of cirrhosis. We gave 150 outpatients with cirrhosis a survey to test disease…”
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Cover Image by Fisher, Natalie C, Loughrey, Maurice B, Coleman, Helen G, Gelbard, Melvin D, Bankhead, Peter, Dunne, Philip D

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Quality Improvement Measures Lead to Higher Surveillance Rates for Hepatocellular Carcinoma in Patients with Cirrhosis by Aberra, Fasika B., Essenmacher, Mary, Fisher, Natalie, Volk, Michael L.

“…Background Cirrhosis is a major risk factor associated with the development of hepatocellular carcinoma (HCC). The American Association for the Study of Liver…”
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Blending recombinant amyloid silk proteins generates composite fibers with tunable mechanical properties by Subramani, Shri Venkatesh, Li, Jingyao, Lee, Kok Zhi, Fisher, Natalie, Zhang, Fuzhong

“…Recent efforts in microbial production of recombinant silk and silk-inspired proteins have yielded fibers with excellent mechanical performances on par with or…”
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Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer by Malla, Sudhir B., Byrne, Ryan M., Lafarge, Maxime W., Corry, Shania M., Fisher, Natalie C., Tsantoulis, Petros K., Mills, Megan L., Ridgway, Rachel A., Lannagan, Tamsin R. M., Najumudeen, Arafath K., Gilroy, Kathryn L., Amirkhah, Raheleh, Maguire, Sarah L., Mulholland, Eoghan J., Belnoue-Davis, Hayley L., Grassi, Elena, Viviani, Marco, Rogan, Emily, Redmond, Keara L., Sakhnevych, Svetlana, McCooey, Aoife J., Bull, Courtney, Hoey, Emily, Sinevici, Nicoleta, Hall, Holly, Ahmaderaghi, Baharak, Domingo, Enric, Blake, Andrew, Richman, Susan D., Isella, Claudio, Miller, Crispin, Bertotti, Andrea, Trusolino, Livio, Loughrey, Maurice B., Kerr, Emma M., Tejpar, Sabine, Maughan, Timothy S., Lawler, Mark, Campbell, Andrew D., Leedham, Simon J., Koelzer, Viktor H., Sansom, Owen J., Dunne, Philip D.

“…Molecular stratification using gene-level transcriptional data has identified subtypes with distinctive genotypic and phenotypic traits, as exemplified by the…”
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Finding the Power Within by Fisher, Natalie Jean

“…The enrollment of nonwhite students in public schools is increasing nationwide. The National Center for Education Statistics (2021) predicts that by the fall…”
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A digital pathology demonstration of an "immune hot" ICOS+/CD45RO+ immunephenotype and the impact on survival in patients with esophageal adenocarcinoma by Humphries, Matthew Philip, Fisher, Natalie, Kacprzyk, Rafal, Craig, Stephanie G, Bingham, Victoria, McQuaid, Stephen, Turkington, Richard C., Murray, Graeme I, James, Jacqueline, Salto-Tellez, Manuel

“…Abstract only 4062 Background: Therapies targeting immune checkpoints are changing our understanding of the biology and treatment of cancer. Analysing the…”
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New strategies for the treatment of ovarian cancer by Robinson, Elizabeth, Fisher, Natalie, Stamelos, Vasileios, Redman, Charles, Richardson, Alan

“…Ovarian cancer usually responds well to chemotherapy, but once the disease becomes resistant to chemotherapy, the treatment options available are inadequate. A…”
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Author Correction: Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer by Malla, Sudhir B., Byrne, Ryan M., Lafarge, Maxime W., Corry, Shania M., Fisher, Natalie C., Tsantoulis, Petros K., Mills, Megan L., Ridgway, Rachel A., Lannagan, Tamsin R. M., Najumudeen, Arafath K., Gilroy, Kathryn L., Amirkhah, Raheleh, Maguire, Sarah L., Mulholland, Eoghan J., Belnoue-Davis, Hayley L., Grassi, Elena, Viviani, Marco, Rogan, Emily, Redmond, Keara L., Sakhnevych, Svetlana, McCooey, Aoife J., Bull, Courtney, Hoey, Emily, Sinevici, Nicoleta, Hall, Holly, Ahmaderaghi, Baharak, Domingo, Enric, Blake, Andrew, Richman, Susan D., Isella, Claudio, Miller, Crispin, Bertotti, Andrea, Trusolino, Livio, Loughrey, Maurice B., Kerr, Emma M., Tejpar, Sabine, Maughan, Timothy S., Lawler, Mark, Campbell, Andrew D., Leedham, Simon J., Koelzer, Viktor H., Sansom, Owen J., Dunne, Philip D.

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