Search Results - "Fisher, Ciarán P"

A systems approach reveals species differences in hepatic stress response capacity by Russomanno, Giusy, Sison-Young, Rowena, Livoti, Lucia A, Coghlan, Hannah, Jenkins, Rosalind E, Kunnen, Steven J, Fisher, Ciarán P, Reddyhoff, Dennis, Gardner, Iain, Rehman, Adeeb H, Fenwick, Stephen W, Jones, Andrew R, Vermeil De Conchard, Guy, Simonin, Gilles, Bertheux, Helene, Weaver, Richard J, Johnson, Robert L, Liguori, Michael J, Clausznitzer, Diana, Stevens, James L, Goldring, Christopher E, Copple, Ian M

“…Abstract To minimize the occurrence of unexpected toxicities in early phase preclinical studies of new drugs, it is vital to understand fundamental…”
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Systems biology approaches for studying the pathogenesis of non-alcoholic fatty liver disease by Fisher, Ciarán P, Kierzek, Andrzej M, Plant, Nick J, Moore, J Bernadette

“…Non-alcoholic fatty liver disease(NAFLD) is a progressive disease of increasing public health concern.In western populations the disease has an estimated…”
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Proteomic identification and characterization of hepatic glyoxalase 1 dysregulation in non-alcoholic fatty liver disease by Spanos, Christos, Maldonado, Elaina M, Fisher, Ciarán P, Leenutaphong, Petchpailin, Oviedo-Orta, Ernesto, Windridge, David, Salguero, Francisco J, Bermúdez-Fajardo, Alexandra, Weeks, Mark E, Evans, Caroline, Corfe, Bernard M, Rabbani, Naila, Thornalley, Paul J, Miller, Michael H, Wang, Huan, Dillon, John F, Quaglia, Alberto, Dhawan, Anil, Fitzpatrick, Emer, Moore, J Bernadette

“…Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide. However, its molecular pathogenesis is incompletely characterized and…”
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Multi-scale, whole-system models of liver metabolic adaptation to fat and sugar in non-alcoholic fatty liver disease by Maldonado, Elaina M., Fisher, Ciarán P., Mazzatti, Dawn J., Barber, Amy L., Tindall, Marcus J., Plant, Nicholas J., Kierzek, Andrzej M., Moore, J. Bernadette

“…Non-alcoholic fatty liver disease (NAFLD) is a serious public health issue associated with high fat, high sugar diets. However, the molecular mechanisms…”
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Integration of Genome Scale Metabolic Networks and Gene Regulation of Metabolic Enzymes With Physiologically Based Pharmacokinetics by Maldonado, Elaina M., Leoncikas, Vytautas, Fisher, Ciarán P., Moore, J. Bernadette, Plant, Nick J., Kierzek, Andrzej M.

“…The scope of physiologically based pharmacokinetic (PBPK) modeling can be expanded by assimilation of the mechanistic models of intracellular processes from…”
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Correction to: Proteomic identification and characterization of hepatic glyoxalase 1 dysregulation in non-alcoholic fatty liver disease by Spanos, Christos, Maldonado, Elaina M, Fisher, Ciarán P, Leenutaphong, Petchpailin, Oviedo-Orta, Ernesto, Windridge, David, Salguero, Francisco J, Bermúdez-Fajardo, Alexandra, Weeks, Mark E, Evans, Caroline, Corfe, Bernard M, Rabbani, Naila, Thornalley, Paul J, Miller, Michael H, Wang, Huan, Dillon, John F, Quaglia, Alberto, Dhawan, Anil, Fitzpatrick, Emer, Moore, J Bernadette

“…[This corrects the article DOI: 10.1186/s12953-018-0131-y.]…”
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QSSPN: dynamic simulation of molecular interaction networks describing gene regulation, signalling and whole-cell metabolism in human cells by Fisher, Ciarán P, Plant, Nicholas J, Moore, J Bernadette, Kierzek, Andrzej M

“…Dynamic simulation of genome-scale molecular interaction networks will enable the mechanistic prediction of genotype-phenotype relationships. Despite advances…”
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Protectiveness of NAM-based hazard assessment – which testing scope is required? by Zobl, Walter, Bitsch, Annette, Blum, Jonathan, Boei, Jan J.W.A, Capinha, Liliana, Carta, Giada, Castell, Jose V, Davoli, Enrico, Drake, Christina, Fisher, Ciaran P, Heldring, Muriel M, Islam, Barira, Jennings, Paul, Leist, Marcel, Pellegrino-Coppola, Damiano, Schimming, Johannes P, Snijders, Kirsten E, Tolosa, Laia, van de Water, Bob, van Vugt-Lussenburg, Barbara M.A, Walker, Paul, Wehr, Matthias M, Wijaya, Lukas S, Escher, Sylvia E

“…Hazard assessment requires toxicity tests to allow deriving protective points of departure (PoDs) for risk assessment irrespective of a compound's mode of…”
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Limitations of acetaminophen as a reference hepatotoxin for the evaluation of in vitro liver models by Livoti, Lucia A, Sison-Young, Rowena, Reddyhoff, Dennis, Fisher, Ciarán P, Gardner, Iain, Diaz-Nieto, Rafael, Goldring, Christopher E, Copple, Ian M

“…Abstract Acetaminophen is commonly used as a reference hepatotoxin to demonstrate that in vitro human liver platforms can emulate features of clinical…”
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HYPERTENSION, CARDIOVASCULAR EVENTS AND SURVIVAL IN RENAL CELL CARCINOMA AND THYROID CANCER PATIENTS TREATED WITH VEGFR TYROSINE KINASE INHIBITORS by Narayan, Vivek, Liu, Tao, Song, Yunjie, Mitchell, Joshua, Sicks, Jorean, Gareen, Ilana F., Sun, Lova, Denduluri, Srinivas, Fisher, Ciaran P, Manikowski, Jesse, Wojtowicz, Mark, Vadakara, Joseph, Haas, Naomi Balzer, Margulies, Kenneth B., Ky, Bonnie

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