Search Results - "Fisher, Amanda G"

DNA Demethylation in Pluripotency and Reprogramming: The Role of Tet Proteins and Cell Division by Bagci, Hakan, Fisher, Amanda G.

“…Cytosine methylation is found in the genomes of many plants and animals and has been associated with transcriptional silencing in mammals. At critical stages…”
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Avrion Mitchison (1928–2022) by Fisher, Amanda G., Merkenschlager, Matthias

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Human X chromosome inactivation and reactivation: implications for cell reprogramming and disease by Cantone, Irene, Fisher, Amanda G.

“…X-chromosome inactivation (XCI) is an exemplar of epigenetic regulation that is set up as pluripotent cells differentiate. Once established, XCI is stably…”
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Chromatin states in pluripotent, differentiated, and reprogrammed cells by Fisher, Cynthia L, Fisher, Amanda G

“…The pluripotent state of embryonic stem cells is maintained by a core network of transcription factors, and by chromatin remodelling factors that support an…”
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Control of inducible gene expression links cohesin to hematopoietic progenitor self-renewal and differentiation by Cuartero, Sergi, Weiss, Felix D., Dharmalingam, Gopuraja, Guo, Ya, Ing-Simmons, Elizabeth, Masella, Silvia, Robles-Rebollo, Irene, Xiao, Xiaolin, Wang, Yi-Fang, Barozzi, Iros, Djeghloul, Dounia, Amano, Mariane T., Niskanen, Henri, Petretto, Enrico, Dowell, Robin D., Tachibana, Kikuë, Kaikkonen, Minna U., Nasmyth, Kim A., Lenhard, Boris, Natoli, Gioacchino, Fisher, Amanda G., Merkenschlager, Matthias

“…Cohesin is important for 3D genome organization. Nevertheless, even the complete removal of cohesin has surprisingly little impact on steady-state gene…”
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Cohesin-based chromatin interactions enable regulated gene expression within preexisting architectural compartments by Seitan, Vlad C, Faure, Andre J, Zhan, Ye, McCord, Rachel Patton, Lajoie, Bryan R, Ing-Simmons, Elizabeth, Lenhard, Boris, Giorgetti, Luca, Heard, Edith, Fisher, Amanda G, Flicek, Paul, Dekker, Job, Merkenschlager, Matthias

“…Chromosome conformation capture approaches have shown that interphase chromatin is partitioned into spatially segregated Mb-sized compartments and sub-Mb-sized…”
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Cell and developmental biology: grand challenges by Fisher, Amanda G

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Spatial enhancer clustering and regulation of enhancer-proximal genes by cohesin by Ing-Simmons, Elizabeth, Seitan, Vlad C, Faure, Andre J, Flicek, Paul, Carroll, Thomas, Dekker, Job, Fisher, Amanda G, Lenhard, Boris, Merkenschlager, Matthias

“…In addition to mediating sister chromatid cohesion during the cell cycle, the cohesin complex associates with CTCF and with active gene regulatory elements to…”
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Cohesins form chromosomal cis-interactions at the developmentally regulated IFNG locus by Hadjur, Suzana, Williams, Luke M., Ryan, Natalie K., Cobb, Bradley S., Sexton, Tom, Fraser, Peter, Fisher, Amanda G., Merkenschlager, Matthias

“…Cohesin branches out As well as its role in sister chromatid cohesion, the cohesin protein complex is thought be involved in the control of gene expression…”
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Inactive yet indispensable: the tale of Jarid2 by Landeira, David, Fisher, Amanda G

“…Methylation of histone tails is believed to be important for the establishment and inheritance of gene expression programs during development. Jarid2/Jumonji…”
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DNA Synthesis Is Required for Reprogramming Mediated by Stem Cell Fusion by Tsubouchi, Tomomi, Soza-Ried, Jorge, Brown, Karen, Piccolo, Francesco M., Cantone, Irene, Landeira, David, Bagci, Hakan, Hochegger, Helfrid, Merkenschlager, Matthias, Fisher, Amanda G.

“…Embryonic stem cells (ESCs) can instruct the conversion of differentiated cells toward pluripotency following cell-to-cell fusion by a mechanism that is rapid…”
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T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR by Sauer, Stephan, Bruno, Ludovica, Hertweck, Arnulf, Finlay, David, Leleu, Marion, Spivakov, Mikhail, Knight, Zachary A, Cobb, Bradley S, Cantrell, Doreen, O'Connor, Eric, Shokat, Kevan M, Fisher, Amanda G, Merkenschlager, Matthias

“…Regulatory T (Treg) cells safeguard against autoimmunity and immune pathology. Because determinants of the Treg cell fate are not completely understood, we…”
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Ring1-mediated ubiquitination of H2A restrains poised RNA polymerase II at bivalent genes in mouse ES cells by Fisher, Amanda G, Pombo, Ana, Stock, Julie K, Giadrossi, Sara, Casanova, Miguel, Brookes, Emily, Vidal, Miguel, Koseki, Haruhiko, Brockdorff, Neil

“…Changes in phosphorylation of the carboxy-terminal domain (CTD) of RNA polymerase II (RNAP) are associated with transcription initiation, elongation and…”
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A deep learning method for replicate-based analysis of chromosome conformation contacts using Siamese neural networks by Al-jibury, Ediem, King, James W. D., Guo, Ya, Lenhard, Boris, Fisher, Amanda G., Merkenschlager, Matthias, Rueckert, Daniel

“…The organisation of the genome in nuclear space is an important frontier of biology. Chromosome conformation capture methods such as Hi-C and Micro-C produce…”
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CHD7 targets active gene enhancer elements to modulate ES cell-specific gene expression by Schnetz, Michael P, Handoko, Lusy, Akhtar-Zaidi, Batool, Bartels, Cynthia F, Pereira, C Filipe, Fisher, Amanda G, Adams, David J, Flicek, Paul, Crawford, Gregory E, Laframboise, Thomas, Tesar, Paul, Wei, Chia-Lin, Scacheri, Peter C

“…CHD7 is one of nine members of the chromodomain helicase DNA-binding domain family of ATP-dependent chromatin remodeling enzymes found in mammalian cells. De…”
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A role for Dicer in immune regulation by Cobb, Bradley S, Hertweck, Arnulf, Smith, James, O'Connor, Eric, Graf, Daniel, Cook, Terence, Smale, Stephen T, Sakaguchi, Shimon, Livesey, Frederick J, Fisher, Amanda G, Merkenschlager, Matthias

“…Micro RNAs (miRNAs) regulate gene expression at the posttranscriptional level. Here we show that regulatory T (T reg) cells have a miRNA profile distinct from…”
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Cohesin-dependence of neuronal gene expression relates to chromatin loop length by Calderon, Lesly, Weiss, Felix D, Beagan, Jonathan A, Oliveira, Marta S, Georgieva, Radina, Wang, Yi-Fang, Carroll, Thomas S, Dharmalingam, Gopuraja, Gong, Wanfeng, Tossell, Kyoko, de Paola, Vincenzo, Whilding, Chad, Ungless, Mark A, Fisher, Amanda G, Phillips-Cremins, Jennifer E, Merkenschlager, Matthias

“…Cohesin and CTCF are major drivers of 3D genome organization, but their role in neurons is still emerging. Here, we show a prominent role for cohesin in the…”
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Chromatin signatures of pluripotent cell lines by Azuara, Véronique, Fisher, Amanda G, Perry, Pascale, Sauer, Stephan, Spivakov, Mikhail, Jørgensen, Helle F, John, Rosalind M, Gouti, Mina, Casanova, Miguel, Warnes, Gary, Merkenschlager, Matthias

“…Epigenetic genome modifications are thought to be important for specifying the lineage and developmental stage of cells within a multicellular organism. Here,…”
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Cohesin couples transcriptional bursting probabilities of inducible enhancers and promoters by Robles-Rebollo, Irene, Cuartero, Sergi, Canellas-Socias, Adria, Wells, Sarah, Karimi, Mohammad M., Mereu, Elisabetta, Chivu, Alexandra G., Heyn, Holger, Whilding, Chad, Dormann, Dirk, Marguerat, Samuel, Rioja, Inmaculada, Prinjha, Rab K., Stumpf, Michael P. H., Fisher, Amanda G., Merkenschlager, Matthias

“…Innate immune responses rely on inducible gene expression programmes which, in contrast to steady-state transcription, are highly dependent on cohesin. Here we…”
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Epigenetic changes induced by in utero dietary challenge result in phenotypic variability in successive generations of mice by Van de Pette, Mathew, Dimond, Andrew, Galvão, António M., Millership, Steven J., To, Wilson, Prodani, Chiara, McNamara, Gráinne, Bruno, Ludovica, Sardini, Alessandro, Webster, Zoe, McGinty, James, French, Paul M. W., Uren, Anthony G., Castillo-Fernandez, Juan, Watkinson, William, Ferguson-Smith, Anne C., Merkenschlager, Matthias, John, Rosalind M., Kelsey, Gavin, Fisher, Amanda G.

“…Transmission of epigenetic information between generations occurs in nematodes, flies and plants, mediated by specialised small RNA pathways, modified histones…”
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