Search Results - "Fish, Richard J."

Fibrin(ogen) in human disease: both friend and foe by Vilar, Rui, Fish, Richard J, Casini, Alessandro, Neerman-Arbez, Marguerite

“…Fibrinogen is an abundant protein synthesized in the liver, present in human blood plasma at concentrations ranging from 1.5-4 g/L in healthy individuals with…”
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Fibrinogen gene regulation by Fish, Richard J, Neerman-Arbez, Marguerite

“…The Aα, Bβ and γ polypeptide chains of fibrinogen are encoded by a three gene cluster on human chromosome four. The fibrinogen genes (FGB-FGA-FGG) are…”
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The effect of genetic variation on promoter usage and enhancer activity by Garieri, Marco, Delaneau, Olivier, Santoni, Federico, Fish, Richard J., Mull, David, Carninci, Piero, Dermitzakis, Emmanouil T., Antonarakis, Stylianos E., Fort, Alexandre

“…The identification of genetic variants affecting gene expression, namely expression quantitative trait loci (eQTLs), has contributed to the understanding of…”
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Venous Thrombosis and Thrombocyte Activity in Zebrafish Models of Quantitative and Qualitative Fibrinogen Disorders by Fish, Richard J, Freire, Cristina, Di Sanza, Corinne, Neerman-Arbez, Marguerite

“…Venous thrombosis occurs in patients with quantitative and qualitative fibrinogen disorders. Injury-induced thrombosis in zebrafish larvae has been used to…”
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The XRN1-regulated RNA helicase activity of YTHDC2 ensures mouse fertility independently of m6A recognition by Li, Lingyun, Krasnykov, Kyrylo, Homolka, David, Gos, Pascal, Mendel, Mateusz, Fish, Richard J., Pandey, Radha Raman, Pillai, Ramesh S.

“…The functional consequence of N6-methyladenosine (m6A) RNA modification is mediated by “reader” proteins of the YTH family. YTH domain-containing 2 (YTHDC2) is…”
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Targeted mutation of zebrafish fga models human congenital afibrinogenemia by Fish, Richard J., Di Sanza, Corinne, Neerman-Arbez, Marguerite

“…Mutations in the human fibrinogen genes can lead to the absence of circulating fibrinogen and cause congenital afibrinogenemia. This rare bleeding disorder is…”
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MicroRNA-126 is a regulator of platelet-supported thrombin generation by Zapilko, Veronika, Fish, Richard J., Garcia, Alix, Reny, Jean-Luc, Dunoyer-Geindre, Sylvie, Lecompte, Thomas, Neerman-Arbez, Marguerite, Fontana, Pierre

“…Circulating microRNA (miRNA) expression profiles correlate with platelet reactivity. MiR-126 is a promising candidates in this regard. We generated a…”
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Effect of Regulatory Element DNA Methylation on Tissue-Type Plasminogen Activator Gene Expression by Dunoyer-Geindre, Sylvie, Rivier-Cordey, Anne-Sophie, Caetano, Carlos, Fish, Richard J, Kruithof, Egbert K O

“…Expression of the tissue-type plasminogen activator gene (t-PA; gene name PLAT) is regulated, in part, by epigenetic mechanisms. We investigated the…”
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A Physiological Function of Inflammation-Associated SerpinB2 Is Regulation of Adaptive Immunity by Schroder, Wayne A, Le, Thuy T. T, Major, Lee, Street, Shayna, Gardner, Joy, Lambley, Eleanore, Markey, Kate, MacDonald, Kelli P, Fish, Richard J, Thomas, Ranjeny, Suhrbier, Andreas

“…SerpinB2 (plasminogen activator inhibitor-2) is widely described as an inhibitor of urokinase plasminogen activator; however, SerpinB2(-/-) mice show no…”
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Divergent JAM-C Expression Accelerates Monocyte-Derived Cell Exit from Atherosclerotic Plaques by Bradfield, Paul F, Menon, Arjun, Miljkovic-Licina, Marijana, Lee, Boris P, Fischer, Nicolas, Fish, Richard J, Kwak, Brenda, Fisher, Edward A, Imhof, Beat A

“…Atherosclerosis, caused in part by monocytes in plaques, continues to be a disease that afflicts the modern world. Whilst significant steps have been made in…”
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DNA methylation profiling of the fibrinogen gene landscape in human cells and during mouse and zebrafish development by Vorjohann, Silja, Pitetti, Jean-Luc, Nef, Serge, Gonelle-Gispert, Carmen, Buhler, Leo, Fish, Richard J, Neerman-Arbez, Marguerite

“…The fibrinogen genes FGA, FGB and FGG show coordinated expression in hepatocytes. Understanding the underlying transcriptional regulation may elucidate how…”
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C2orf62 and TTC17 are involved in actin organization and ciliogenesis in zebrafish and human by Bontems, Franck, Fish, Richard J, Borlat, Irene, Lembo, Frédérique, Chocu, Sophie, Chalmel, Frédéric, Borg, Jean-Paul, Pineau, Charles, Neerman-Arbez, Marguerite, Bairoch, Amos, Lane, Lydie

“…Vertebrate genomes contain around 20,000 protein-encoding genes, of which a large fraction is still not associated with specific functions. A major task in…”
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The role of TLR2 in the inflammatory activation of mouse fibroblasts by human antiphospholipid antibodies by Satta, Nathalie, Dunoyer-Geindre, Sylvie, Reber, Guido, Fish, Richard J., Boehlen, Francoise, Kruithof, Egbert K.O., de Moerloose, Philippe

“…Antiphospholipid antibodies (APLAs) promote inflammatory and procoagulant responses in endothelial cells and monocytes. Previous studies have shown that MyD88,…”
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A liver enhancer in the fibrinogen gene cluster by Fort, Alexandre, Fish, Richard J., Attanasio, Catia, Dosch, Roland, Visel, Axel, Neerman-Arbez, Marguerite

“…The plasma concentration of fibrinogen varies in the healthy human population between 1.5 and 3.5 g/L. Understanding the basis of this variability has clinical…”
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Gene conversion limits divergence of mammalian TLR1 and TLR6 by Kruithof, Egbert K O, Satta, Nathalie, Liu, Jia Wei, Dunoyer-Geindre, Sylvie, Fish, Richard J

“…Toll-like receptors (TLR) recognize pathogen-associated molecular patterns and are important mediators of the innate immune system. TLR1 and TLR6 are paralogs…”
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tfec controls the hematopoietic stem cell vascular niche during zebrafish embryogenesis by Mahony, Christopher B., Fish, Richard J., Pasche, Corentin, Bertrand, Julien Y.

“…In mammals, embryonic hematopoiesis occurs in successive waves, culminating with the emergence of hematopoietic stem cells (HSCs) in the aorta. HSCs first…”
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Methods to Investigate miRNA Function: Focus on Platelet Reactivity by Garcia, Alix, Dunoyer-Geindre, Sylvie, Fish, Richard J, Neerman-Arbez, Marguerite, Reny, Jean-Luc, Fontana, Pierre

“…MicroRNAs (miRNAs) are small noncoding RNAs modulating protein production. They are key players in regulation of cell function and are considered as biomarkers…”
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Fluvastatin inhibits regulated secretion of endothelial cell von Willebrand factor in response to diverse secretagogues by Fish, Richard J, Yang, Hong, Viglino, Christelle, Schorer, Raoul, Dunoyer-Geindre, Sylvie, Kruithof, Egbert K O

“…Regulated secretion of EC (endothelial cell) vWF (von Willebrand factor) is part of the haemostatic response. It occurs in response to secretagogues that raise…”
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Regulation of fibrinogen synthesis by Dobson, Dre'Von A., Fish, Richard J., de Vries, Paul S., Morrison, Alanna C., Neerman-Arbez, Marguerite, Wolberg, Alisa S.

“…The plasma protein fibrinogen is encoded by 3 structural genes (FGA, FGB, and FGG) that are transcribed to mRNA, spliced, and translated to 3 polypeptide…”
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Deep Cap Analysis of Gene Expression (CAGE): Genome-Wide Identification of Promoters, Quantification of Their Activity, and Transcriptional Network Inference by Fort, Alexandre, Fish, Richard J

“…Among the most significant findings of the post-genomic era, the discovery of pervasive transcription of mammalian genomes has tremendously modified our…”
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