Search Results - "Fischman, Marian W."

Abstinence symptoms following oral THC administration to humans by HANEY, M, WARD, A. S, COMER, S. D, FOLTIN, R. W, FISCHMAN, M. W

“…Symptoms of dependence and withdrawal after the frequent administration of high doses (210 mg/day) of oral delta9-tetrahydrocannabinol (THC) have been…”
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Intravenous buprenorphine self-administration by detoxified heroin abusers by Comer, Sandra D, Collins, Eric D, Fischman, Marian W

“…Several sources indicate that intravenously administered buprenorphine may have significant abuse liability in humans. The present study evaluated the…”
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Dopamine D1 Receptors in Cocaine Dependence Measured with PET and the Choice to Self-Administer Cocaine by Martinez, Diana, Slifstein, Mark, Narendran, Rajesh, Foltin, Richard W, Broft, Allegra, Hwang, Dah-Ren, Perez, Audrey, Abi-Dargham, Anissa, Fischman, Marian W, Kleber, Herbert D, Laruelle, Marc

“…The goal of this study was to determine D(1) receptor availability in human cocaine-dependent (CD) subjects and matched healthy controls (HCs). In addition,…”
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Cocaine dependence and D2 receptor availability in the functional subdivisions of the striatum: Relationship with cocaine-seeking behavior by MARTINEZ, Diana, BROFT, Allegra, FISCHMAN, Marian W, LARUELLE, Marc, FOLTIN, Richard W, SLIFSTEIN, Mark, HWANG, Dah-Ren, YIYUN HUANG, PEREZ, Audrey, FRANKEL, W. Gordon, COOPER, Thomas, KLEBER, Herbert D

“…Striatal dopamine D2 receptors have been implicated in the neurobiology of cocaine addiction. Previous imaging studies showed reduced striatal D2 receptor…”
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Binge cocaine self-administration in humans : intravenous cocaine by WARD, A. S, HANEY, M, FISCHMAN, M. W, FOLTIN, R. W

“…Cocaine is frequently used in intermittent cycles of repeated dosing, or "binges." This pattern of cocaine use has been difficult to study in humans because…”
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Amphetamine-Induced Dopamine Release: Markedly Blunted in Cocaine Dependence and Predictive of the Choice to Self-Administer Cocaine by Martinez, Diana, Narendran, Rajesh, Foltin, Richard W., Slifstein, Mark, Hwang, Dah-Ren, Broft, Allegra, Huang, Yiyun, Cooper, Thomas B., Fischman, Marian W., Kleber, Herbert D., Laruelle, Marc

“…Objective: Dopamine is an important mediator of the reinforcing effects of cocaine, and alterations in dopamine function might be involved in cocaine…”
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Effects of Acute Smoked Marijuana on Complex Cognitive Performance by Hart, Carl L, van Gorp, Wilfred, Haney, Margaret, Foltin, Richard W, Fischman, Marian W

“…Although the ability to perform complex cognitive operations is assumed to be impaired following acute marijuana smoking, complex cognitive performance after…”
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A Phase 3 placebo-controlled, double-blind, multi-site trial of the alpha-2-adrenergic agonist, lofexidine, for opioid withdrawal by Yu, Elmer, Miotto, Karen, Akerele, Evaristo, Montgomery, Ann, Elkashef, Ahmed, Walsh, Robert, Montoya, Ivan, Fischman, Marian W, Collins, Joseph, McSherry, Frances, Boardman, Kathy, Davies, David K, O’Brien, Charles P, Ling, Walter, Kleber, Herbert, Herman, Barbara H

“…Abstract Context Lofexidine is an alpha-2-adrenergic receptor agonist that is approved in the United Kingdom for the treatment of opioid withdrawal symptoms…”
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Comparison of smoked marijuana and oral Delta(9)-tetrahydrocannabinol in humans by Hart, Carl L, Ward, Amie S, Haney, Margaret, Comer, Sandra D, Foltin, Richard W, Fischman, Marian W

“…Although smoked marijuana contains at least 60 cannabinoids, delta(9)-tetrahydrocannabinol (delta(9)-THC) is presumed to be the cannabinoid primarily…”
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Abstinence symptoms following smoked marijuana in humans by HANEY, M, WARD, A. S, COMER, S. D, FOLTIN, R. W, FISCHMAN, M. W

“…Symptoms of withdrawal after oral delta9-tetrahydrocannabinol (THC) administration have been reported, yet little is known about the development of dependence…”
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Effects of the NMDA antagonist memantine on human methamphetamine discrimination by HART, Carl L, HANEY, Margaret, FOLTIN, Richard W, FISCHMAN, Marian W

“…The discriminative stimulus effects of N-methyl- D-aspartate (NMDA) antagonists have been assessed in laboratory animals. To date, no published study has…”
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Depot naltrexone: long-lasting antagonism of the effects of heroin in humans by COMER, Sandra D, COLLINS, Eric D, KLEBER, Herbert D, NUWAYSER, Elie S, KERRIGAN, James H, FISCHMAN, Marian W

“…Naltrexone, an opioid antagonist, is currently approved as a treatment for heroin dependence. However, naltrexone is generally not well accepted by patients,…”
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Bupropion SR worsens mood during marijuana withdrawal in humans by HANEY, Margaret, WARD, Amie S, COMER, Sandra D, HART, Carl L, FOLTIN, Richard W, FISCHMAN, Marian W

“…Symptoms of withdrawal after daily marijuana smoking include increased ratings of irritability and depression. Similar mood symptoms are reported by cigarette…”
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Effects of oral THC maintenance on smoked marijuana self-administration by HART, Carl L, HANEY, Margaret, WARD, Amie S, FISCHMAN, Marian W, FOLTIN, Richard W

“…Studies have shown that the Delta(9)-tetrahydrocannabinol (Delta(9)-THC) concentration in marijuana cigarettes is an important factor for the maintenance of…”
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Effect of a selective dopamine D1 agonist (ABT-431) on smoked cocaine self-administration in humans by HANEY, M, COLLINS, E. D, WARD, A. S, FOLTIN, R. W, FISCHMAN, M. W

“…Data in laboratory animals suggest that D1 receptor agonists may have potential utility for the treatment of cocaine abuse. The effects of ABT-431, a selective…”
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Buprenorphine sublingual tablets : effects on IV heroin self-administration by humans by COMER, Sandra D, COLLINS, Eric D, FISCHMAN, Marian W

“…Studies have shown that buprenorphine, a partial mu opioid agonist, effectively reduces heroin taking. While previous research with buprenorphine utilized a…”
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Satiety after preloads with different amounts of fat and carbohydrate: implications for obesity by Rolls, BJ, Kim-Harris, S, Fischman, MW, Foltin, RW, Moran, TH, Stoner, SA

“…High intake of dietary fat may be key in both the etiology and maintenance of obesity. Because a reduction in the proportion of energy derived from fat will be…”
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Comparison of intravenous and intranasal heroin self-administration by morphine-maintained humans by COMER, S. D, COLLINS, E. D, MACARTHUR, R. B, FISCHMAN, M. W

“…Eight heroin-dependent individuals, maintained on divided daily doses of oral morphine, participated in a 2.5-week inpatient study comparing the effects of…”
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Clinical Pharmacokinetics of Lofexidine, the α 2-Adrenergic Receptor Agonist, in Opiate Addicts Plasma Using a Highly Sensitive Liquid Chromatography Tandem Mass Spectrometric Analysis by Yu, Elmer, Miotto, Karen, Akerele, Evaristo, O'Brien, Charles P., Ling, Walter, Kleber, Herbert, Fischman, Marian W., Elkashef, Ahmed, Herman, Barbara H., Al-Ghananeem, Abeer M.

“…Objectives: The objective of this investigation was to characterize the pharmacokinetic profile of lofexidine. Lofexidine is an orally bioavailable α…”
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Effects of pergolide on intravenous cocaine self-administration in men and women by HANEY, M, FOLTIN, R. W, FISCHMAN, M. W

“…Clinical evidence suggests that pergolide, a D1/D2 dopamine receptor agonist, may be useful in maintaining cocaine abstinence. We investigated pergolide's…”
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