Search Results - "Fischetti, Vincent"

Development of Phage Lysins as Novel Therapeutics: A Historical Perspective by Fischetti, Vincent A

“…Bacteriophage lysins and related bacteriolytic enzymes are now considered among the top antibiotic alternatives for solving the mounting resistance problem…”
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Isolation of Clostridium perfringens type B in an individual at first clinical presentation of multiple sclerosis provides clues for environmental triggers of the disease by Rumah, Kareem Rashid, Linden, Jennifer, Fischetti, Vincent A, Vartanian, Timothy

“…We have isolated Clostridium perfringens type B, an epsilon toxin-secreting bacillus, from a young woman at clinical presentation of Multiple Sclerosis (MS)…”
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Bacteriophage endolysins: A novel anti-infective to control Gram-positive pathogens by Fischetti, Vincent A

“…Abstract Endolysins (or lysins) are highly evolved enzymes produced by bacteriophage (phage for short) to digest the bacterial cell wall for phage progeny…”
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Bacteriophage lysins as effective antibacterials by Fischetti, Vincent A

“…Lysins are highly evolved enzymes produced by bacteriophage (phage for short) to digest the bacterial cell wall for phage progeny release. In Gram-positive…”
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Exploiting CRISPR-Cas nucleases to produce sequence-specific antimicrobials by Bikard, David, Euler, Chad W, Jiang, Wenyan, Nussenzweig, Philip M, Goldberg, Gregory W, Duportet, Xavier, Fischetti, Vincent A, Marraffini, Luciano A

“…Coupling the specificity of CRISPR-Cas nucleases and bacteriophage delivery enables exquisitely precise bacterial killing. Antibiotics target conserved…”
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Strains of bacterial species induce a greatly varied acute adaptive immune response: The contribution of the accessory genome by Sela, Uri, Euler, Chad W, Correa da Rosa, Joel, Fischetti, Vincent A

“…A fundamental question in human susceptibility to bacterial infections is to what extent variability is a function of differences in the pathogen species or in…”
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Isolation of Phage Lysins That Effectively Kill Pseudomonas aeruginosa in Mouse Models of Lung and Skin Infection by Raz, Assaf, Serrano, Anna, Hernandez, Anaise, Euler, Chad W, Fischetti, Vincent A

“…Multidrug resistance (MDR) is rapidly increasing in prevalence among isolates of the opportunistic pathogen , leaving few treatment options. Phage lysins are…”
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Decontamination of Escherichia coli O157:H7 on fresh Romaine lettuce using a novel bacteriophage lysin by Xu, Siyue, Campisi, Edmondo, Li, Jinquan, Fischetti, Vincent A.

“…Raw vegetables are a key food for a healthy diet, but their increased consumption brings a higher risk for foodborne disease. Contamination of salad greens…”
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Lysocins: Bioengineered Antimicrobials That Deliver Lysins across the Outer Membrane of Gram-Negative Bacteria by Heselpoth, Ryan D, Euler, Chad W, Schuch, Raymond, Fischetti, Vincent A

“…The prevalence of multidrug-resistant has stimulated development of alternative therapeutics. Bacteriophage peptidoglycan hydrolases, termed lysins, represent…”
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The secret life of the anthrax agent Bacillus anthracis: bacteriophage-mediated ecological adaptations by Schuch, Raymond, Fischetti, Vincent A

“…Ecological and genetic factors that govern the occurrence and persistence of anthrax reservoirs in the environment are obscure. A central tenet, based on…”
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Alternatives to antibiotics—a pipeline portfolio review by Czaplewski, Lloyd, Dr, Bax, Richard, MD, Clokie, Martha, Prof, Dawson, Mike, PhD, Fairhead, Heather, PhD, Fischetti, Vincent A, Prof, Foster, Simon, Prof, Gilmore, Brendan F, Prof, Hancock, Robert E W, Prof, Harper, David, PhD, Henderson, Ian R, Prof, Hilpert, Kai, PhD, Jones, Brian V, PhD, Kadioglu, Aras, Prof, Knowles, David, PhD, Ólafsdóttir, Sigríður, PhD, Payne, David, PhD, Projan, Steve, PhD, Shaunak, Sunil, Prof, Silverman, Jared, PhD, Thomas, Christopher M, Prof, Trust, Trevor J, PhD, Warn, Peter, PhD, Rex, John H, MD

“…Summary Antibiotics have saved countless lives and enabled the development of modern medicine over the past 70 years. However, it is clear that the success of…”
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Novel phage lysin capable of killing the multidrug-resistant gram-negative bacterium Acinetobacter baumannii in a mouse bacteremia model by Lood, Rolf, Winer, Benjamin Y, Pelzek, Adam J, Diez-Martinez, Roberto, Thandar, Mya, Euler, Chad W, Schuch, Raymond, Fischetti, Vincent A

“…Acinetobacter baumannii, a Gram-negative multidrug-resistant (MDR) bacterium, is now recognized as one of the more common nosocomial pathogens. Because most…”
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Lysins: the arrival of pathogen-directed anti-infectives by PASTAGIA, Mina, SCHUCH, Raymond, FISCHETTI, Vincent A, HUANG, David B

“…Lysins represent a novel class of anti-infectives derived from bacteriophage. Lysins are bacterial cell-wall hydrolytic enzymes that selectively and rapidly…”
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Determining bacteriophage endopeptidase activity using either fluorophore-quencher labeled peptides combined with liquid chromatography-mass spectrometry (LC-MS) or Förster resonance energy transfer (FRET) assays by Lood, Rolf, Molina, Henrik, Fischetti, Vincent A

“…The necessity of identifying novel methods to combat infections caused by antibiotic resistant bacteria is increasing each year. Recent advancements in the…”
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Novel Bacteriophage Lysin with Broad Lytic Activity Protects against Mixed Infection by Streptococcus pyogenes and Methicillin-Resistant Staphylococcus aureus by GILMER, Daniel B, SCHMITZ, Jonathan E, EULER, Chad W, FISCHETTI, Vincent A

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Bacteriophage lytic enzymes: novel anti-infectives by Fischetti, Vincent A.

“…Bacteriophage lytic enzymes, or lysins, are highly evolved molecules produced by bacterial viruses (bacteriophage) to digest the bacterial cell wall for…”
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Novel Engineered Peptides of a Phage Lysin as Effective Antimicrobials against Multidrug-Resistant Acinetobacter baumannii by Thandar, Mya, Lood, Rolf, Winer, Benjamin Y, Deutsch, Douglas R, Euler, Chad W, Fischetti, Vincent A

“…Acinetobacter baumannii is a Gram-negative bacterial pathogen responsible for a range of nosocomial infections. The recent rise and spread of…”
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Encapsulation and delivery of phage as a novel method for gut flora manipulation in situ: A review by Yang, Yufan, Du, Hu, Zou, Geng, Song, Zhiyong, Zhou, Yang, Li, Hao, Tan, Chen, Chen, Huanchun, Fischetti, Vincent A., Li, Jinquan

“…Intestinal flora regulation is an effective method to intervene and treat diseases associated with microbiome imbalance. In addition to conventional probiotic…”
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Surface Proteins on Gram-Positive Bacteria by Fischetti, Vincent A

“…Surface proteins are critical for the survival of gram-positive bacteria both in the environment and to establish an infection. Depending on the organism,…”
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Genetic diversity among Enterococcus faecalis by McBride, Shonna M, Fischetti, Vincent A, Leblanc, Donald J, Moellering, Jr, Robert C, Gilmore, Michael S

“…Enterococcus faecalis, a ubiquitous member of mammalian gastrointestinal flora, is a leading cause of nosocomial infections and a growing public health…”
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