Search Results - "Fischer, Miranda"

Mitigation of endemic GI-tract pathogen-mediated inflammation through development of multimodal treatment regimen and its impact on SIV acquisition in rhesus macaques by Bochart, Rachele M, Busman-Sahay, Kathleen, Bondoc, Stephen, Morrow, David W, Ortiz, Alexandra M, Fennessey, Christine M, Fischer, Miranda B, Shiel, Oriene, Swanson, Tonya, Shriver-Munsch, Christine M, Crank, Hugh B, Armantrout, Kimberly M, Barber-Axthelm, Aaron M, Langner, Charlotte, Moats, Cassandra R, Labriola, Caralyn S, MacAllister, Rhonda, Axthelm, Michael K, Brenchley, Jason M, Keele, Brandon F, Estes, Jacob D, Hansen, Scott G, Smedley, Jeremy V

“…Here, we assessed the efficacy of a short-course multimodal therapy (enrofloxacin, azithromycin, fenbendazole, and paromomycin) to eliminate common macaque…”
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Correction: Mitigation of endemic GI-tract pathogen-mediated inflammation through development of multimodal treatment regimen and its impact on SIV acquisition in rhesus macaques by Bochart, Rachele M, Busman-Sahay, Kathleen, Bondoc, Stephen, Morrow, David W, Ortiz, Alexandra M, Fennessey, Christine M, Fischer, Miranda B, Shiel, Oriene, Swanson, Tonya, Shriver-Munsch, Christine M, Crank, Hugh B, Armantrout, Kimberly M, Barber-Axthelm, Aaron M, Langner, Charlotte, Moats, Cassandra R, Labriola, Caralyn S, MacAllister, Rhonda, Axthelm, Michael K, Brenchley, Jason M, Keele, Brandon F, Estes, Jacob D, Hansen, Scott G, Smedley, Jeremy V

“…[This corrects the article DOI: 10.1371/journal.ppat.1009565.]…”
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Single-dose bNAb cocktail or abbreviated ART post-exposure regimens achieve tight SHIV control without adaptive immunity by Shapiro, Mariya B., Cheever, Tracy, Malherbe, Delphine C., Pandey, Shilpi, Reed, Jason, Yang, Eun Sung, Wang, Keyun, Pegu, Amarendra, Chen, Xuejun, Siess, Don, Burke, David, Henderson, Heidi, Lewinsohn, Rebecca, Fischer, Miranda, Stanton, Jeffrey J., Axthelm, Michael K., Kahl, Christoph, Park, Byung, Lewis, Anne D., Sacha, Jonah B., Mascola, John R., Hessell, Ann J., Haigwood, Nancy L.

“…Vertical transmission accounts for most human immunodeficiency virus (HIV) infection in children, and treatments for newborns are needed to abrogate infection…”
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Long-term hepatitis B virus infection of rhesus macaques requires suppression of host immunity by Biswas, Sreya, Rust, Lauren N., Wettengel, Jochen M., Yusova, Sofiya, Fischer, Miranda, Carson, Julien N., Johnson, Josie, Wei, Lei, Thode, Trason, Kaadige, Mohan R., Sharma, Sunil, Agbaria, Majd, Bimber, Benjamin N., Tu, Thomas, Protzer, Ulrike, Ploss, Alexander, Smedley, Jeremy V., Golomb, Gershon, Sacha, Jonah B., Burwitz, Benjamin J.

“…Hepatitis B virus has infected a third of the world’s population, and 296 million people are living with chronic infection. Chronic infection leads to…”
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Antibody-based CCR5 blockade protects Macaques from mucosal SHIV transmission by Chang, Xiao L., Webb, Gabriela M., Wu, Helen L., Greene, Justin M., Abdulhaqq, Shaheed, Bateman, Katherine B., Reed, Jason S., Pessoa, Cleiton, Weber, Whitney C., Maier, Nicholas, Chew, Glen M., Gilbride, Roxanne M., Gao, Lina, Agnor, Rebecca, Giobbi, Travis, Torgerson, Jeffrey, Siess, Don, Burnett, Nicole, Fischer, Miranda, Shiel, Oriene, Moats, Cassandra, Patterson, Bruce, Dhody, Kush, Kelly, Scott, Pourhassan, Nader, Magnani, Diogo M., Smedley, Jeremy, Bimber, Benjamin N., Haigwood, Nancy L., Hansen, Scott G., Brown, Timothy R., Ndhlovu, Lishomwa C., Sacha, Jonah B.

“…In the absence of a prophylactic vaccine, the use of antiretroviral therapy (ART) as pre-exposure prophylaxis (PrEP) to prevent HIV acquisition by uninfected…”
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CD4 T cell immunity is critical for the control of simian varicella virus infection in a nonhuman primate model of VZV infection by Haberthur, Kristen, Engelmann, Flora, Park, Byng, Barron, Alex, Legasse, Alfred, Dewane, Jesse, Fischer, Miranda, Kerns, Amelia, Brown, Monica, Messaoudi, Ilhem

“…Primary infection with varicella zoster virus (VZV) results in varicella (more commonly known as chickenpox) after which VZV establishes latency in sensory…”
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Identification of Vancomycin Resistance in Methicillin-resistant Staphylococcus aureus in two macaque species and decolonization and long-term prevention of recolonization in Cynomolgus Macaques ( Macaca fascicularis ) by Bochart, Rachele M, Armantrout, Kimberly, Crank, Hugh, Tonelli, Rachael, Shriver-Munsch, Christine, Swanson, Tonya, Fischer, Miranda, Wu, Helen, Axthelm, Michael, Sacha, Jonah, Smedley, Jeremy V

“…Methicillin-resistant (MRSA) is a strain with resistance to beta-lactam antibiotics, making it a global human and veterinary health concern. Specifically,…”
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Suppression of human and simian immunodeficiency virus replication with the CCR5-specific antibody Leronlimab in two species by Chang, Xiao L, Reed, Jason S, Webb, Gabriela M, Wu, Helen L, Le, Jimmy, Bateman, Katherine B, Greene, Justin M, Pessoa, Cleiton, Waytashek, Courtney, Weber, Whitney C, Hwang, Joseph, Fischer, Miranda, Moats, Cassandra, Shiel, Oriene, Bochart, Rachele M, Crank, Hugh, Siess, Don, Giobbi, Travis, Torgerson, Jeffrey, Agnor, Rebecca, Gao, Lina, Dhody, Kush, Lalezari, Jacob P, Bandar, Ivo Sah, Carnate, Alnor M, Pang, Alina S, Corley, Michael J, Kelly, Scott, Pourhassan, Nader, Smedley, Jeremy, Bimber, Benjamin N, Hansen, Scott G, Ndhlovu, Lishomwa C, Sacha, Jonah B

“…The CCR5-specific antibody Leronlimab is being investigated as a novel immunotherapy that can suppress HIV replication with minimal side effects. Here we…”
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CCR5 Receptor Occupancy Analysis Reveals Increased Peripheral Blood CCR5+CD4+ T Cells Following Treatment With the Anti-CCR5 Antibody Leronlimab by Chang, Xiao L, Wu, Helen L, Webb, Gabriela M, Tiwary, Meenakshi, Hughes, Colette, Reed, Jason S, Hwang, Joseph, Waytashek, Courtney, Boyle, Carla, Pessoa, Cleiton, Sylwester, Andrew W, Morrow, David, Belica, Karina, Fischer, Miranda, Kelly, Scott, Pourhassan, Nader, Bochart, Rachele M, Smedley, Jeremy, Recknor, Christopher P, Hansen, Scott G, Sacha, Jonah B

“…CCR5 plays a central role in infectious disease, host defense, and cancer progression, thereby making it an ideal target for therapeutic development. Notably,…”
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SIV Infection Is Associated with Transient Acute-Phase Steatosis in Hepatocytes In Vivo by Derby, Nina, Biswas, Sreya, Yusova, Sofiya, Luevano-Santos, Cristina, Pacheco, Maria Cristina, Meyer, Kimberly A, Johnson, Brooke I, Fischer, Miranda, Fancher, Katherine A, Fisher, Cole, Abraham, Yohannes M, McMahon, Conor J, Lutz, Savannah S, Smedley, Jeremy V, Burwitz, Benjamin J, Sodora, Donald L

“…Metabolic-dysfunction-associated fatty liver disease (MAFLD) is a major cause of morbidity and mortality in HIV-infected individuals, even those receiving…”
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Medulloblastoma in the Molecular Era by Miranda Kuzan-Fischer, Claudia, Juraschka, Kyle, Taylor, Michael D

“…Medulloblastoma is the most common malignant brain tumor of childhood and remains a major cause of cancer related mortality in children. Significant scientific…”
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Delay of T Cell Senescence by Caloric Restriction in Aged Long-Lived Nonhuman Primates by Messaoudi, Ilhem, Warner, Jessica, Fischer, Miranda, Park, Buyng, Hill, Brenna, Mattison, Julie, Lanes, Mark A., Roth, George S., Ingram, Donald K., Picker, Louis J., Douek, Daniel C., Mori, Motomi, Nikolich-Žugich, Janko

“…Caloric restriction (CR) has long been known to increase median and maximal lifespans and to decreases mortality and morbidity in short-lived animal models,…”
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Cytomegalovirus-specific T cell immunity is maintained in immunosenescent rhesus macaques by Cicin-Sain, Luka, Sylwester, Andrew W, Hagen, Shoko I, Siess, Don C, Currier, Noreen, Legasse, Alfred W, Fischer, Miranda B, Koudelka, Caroline W, Axthelm, Michael K, Nikolich-Zugich, Janko, Picker, Louis J

“…Although CMV infection is largely benign in immunocompetent people, the specific T cell responses associated with control of this persistent virus are enormous…”
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Dramatic increase in naïve T cell turnover is linked to loss of naïve T cells from old primates by Čičin-Šain, Luka, Messaoudi, Ilhem, Park, Byung, Currier, Noreen, Planer, Shannon, Fischer, Miranda, Tackitt, Shane, Nikolich-Žugich, Dragana, Legasse, Alfred, Axthelm, Michael K, Picker, Louis J, Mori, Motomi, Nikolich-Žugich, Janko

“…The loss of naïve T cells is a hallmark of immune aging. Although thymic involution is a primary driver of this naïve T cell loss, less is known about the…”
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Prevention of tuberculosis in rhesus macaques by a cytomegalovirus-based vaccine by Hansen, Scott G, Zak, Daniel E, Xu, Guangwu, Ford, Julia C, Marshall, Emily E, Malouli, Daniel, Gilbride, Roxanne M, Hughes, Colette M, Ventura, Abigail B, Ainslie, Emily, Randall, Kurt T, Selseth, Andrea N, Rundstrom, Parker, Herlache, Lauren, Lewis, Matthew S, Park, Haesun, Planer, Shannon L, Turner, John M, Fischer, Miranda, Armstrong, Christina, Zweig, Robert C, Valvo, Joseph, Braun, Jackie M, Shankar, Smitha, Lu, Lenette, Sylwester, Andrew W, Legasse, Alfred W, Messerle, Martin, Jarvis, Michael A, Amon, Lynn M, Aderem, Alan, Alter, Galit, Laddy, Dominick J, Stone, Michele, Bonavia, Aurelio, Evans, Thomas G, Axthelm, Michael K, Früh, Klaus, Edlefsen, Paul T, Picker, Louis J

“…Complete vaccine-mediated immune control of highly pathogenic Mycobacterium tuberculosis is possible if immune effector responses can intercept the infection…”
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Cytomegalovirus Vectors Violate CD8⁺ T Cell Epitope Recognition Paradigms by Hansen, Scott G., Sacha, Jonah B., Hughes, Colette M., Ford, Julia C., Burwitz, Benjamin J., Scholz, Isabel, Gilbride, Roxanne M., Lewis, Matthew S., Gilliam, Awbrey N., Ventura, Abigail B., Malouli, Daniel, Xu, Guangwu, Richards, Rebecca, Whizin, Nathan, Reed, Jason S., Hammond, Katherine B., Fischer, Miranda, Turner, John M., Legasse, Alfred W., Axthelm, Michael K., Edlefsen, Paul T., Nelson, Jay A., Lifson, Jeffrey D., Früh, Klaus, Picker, Louis J.

“…CD8(+) T cell responses focus on a small fraction of pathogen- or vaccine-encoded peptides, and for some pathogens, these restricted recognition hierarchies…”
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Immune restoration by TIGIT blockade is insufficient to control chronic SIV infection by Webb, Gabriela M, Pessoa, Cleiton T, McCullen, Allyson J, Hwang, Joseph M, Humkey, Matthew C, Thormin-Odum, Raymond, Kukula, Kaitlyn A, Smedley, Jeremy, Fischer, Miranda, Sciurba, Joseph, Bochart, Rachele M, Shriver-Munsch, Christine, Ndhlovu, Lishomwa C, Sacha, Jonah B

“…TIGIT is a negative immune checkpoint receptor associated with T cell exhaustion in cancer and HIV. TIGIT upregulation in virus-specific CD8 T cells and NK…”
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Protection of Newborn Macaques by Plant-Derived HIV Broadly Neutralizing Antibodies: a Model for Passive Immunotherapy during Breastfeeding by Rosenberg, Yvonne J, Jiang, Xiaoming, Cheever, Tracy, Coulter, Felicity J, Pandey, Shilpi, Sack, Markus, Mao, Lingjun, Urban, Lori, Lees, Jonathan, Fischer, Miranda, Smedley, Jeremy, Sidener, Heather, Stanton, Jeffrey, Haigwood, Nancy L

“…Preventing human immunodeficiency virus (HIV) infection in newborns by vertical transmission remains an important unmet medical need in resource-poor areas…”
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A model of lymphocryptovirus-associated post-transplant lymphoproliferative disorder in immunosuppressed Mauritian cynomolgus macaques by Wu, Helen L., Weber, Whitney C., Waytashek, Courtney M., Boyle, Carla D., Reed, Jason S., Bateman, Katherine B., Fisher, Hannah K., Chen, Yan, Armantrout, Kimberly, Swanson, Tonya, Shriver-Munsch, Christine, Northrup, Mina, Fischer, Miranda, Biswas, Sreya, Templon, John, Panoskaltsis-Mortari, Angela, Burwitz, Benjamin J., Johnson, Amanda L., Colgin, Lois, Lewis, Anne D., Smedley, Jeremy V., Axthelm, Michael K., Skalsky, Rebecca, Meyers, Gabrielle, Maziarz, Richard T., Mittra, Erik, Berg, Melissa, Stanton, Jeffrey J., Sacha, Jonah B.

“…Immunocompromised individuals are at risk for developing lymphocryptovirus-associated lymphoproliferative diseases, such as Epstein Barr virus (EBV)-associated…”
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Loss of naive T cells and repertoire constriction predict poor response to vaccination in old primates by Cicin-Sain, Luka, Smyk-Pearson, Susan, Smyk-Paerson, Sue, Currier, Noreen, Byrd, Laura, Koudelka, Caroline, Robinson, Tammie, Swarbrick, Gwendolyn, Tackitt, Shane, Legasse, Alfred, Fischer, Miranda, Nikolich-Zugich, Dragana, Park, Byung, Hobbs, Theodore, Doane, Cynthia J, Mori, Motomi, Axthelm, Michael K, Axthelm, Michael T, Lewinsohn, Deborah A, Nikolich-Zugich, Janko

“…Aging is usually accompanied by diminished immune protection upon infection or vaccination. Although aging results in well-characterized changes in the T cell…”
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