Search Results - "Fischer, Marcus"

Intratumoural heterogeneity generated by Notch signalling promotes small-cell lung cancer by Lim, Jing Shan, Ibaseta, Alvaro, Fischer, Marcus M., Cancilla, Belinda, O’Young, Gilbert, Cristea, Sandra, Luca, Vincent C., Yang, Dian, Jahchan, Nadine S., Hamard, Cécile, Antoine, Martine, Wislez, Marie, Kong, Christina, Cain, Jennifer, Liu, Yu-Wang, Kapoun, Ann M., Garcia, K. Christopher, Hoey, Timothy, Murriel, Christopher L., Sage, Julien

“…In a mouse model of small-cell lung cancer and in human tumours, activation of the Notch pathway can lead to a cell fate switch of neuroendocrine cells to less…”
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Alterations of plasma lysophosphatidylcholine species in obesity and weight loss by Heimerl, Susanne, Fischer, Marcus, Baessler, Andrea, Liebisch, Gerhard, Sigruener, Alexander, Wallner, Stefan, Schmitz, Gerd

“…Obesity and related diseases of the metabolic syndrome contribute to the major health problems in industrialized countries. Alterations in the metabolism of…”
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Targeting Notch signaling with a Notch2/Notch3 antagonist (tarextumab) inhibits tumor growth and decreases tumor-initiating cell frequency by Yen, Wan-Ching, Fischer, Marcus M, Axelrod, Fumiko, Bond, Christopher, Cain, Jennifer, Cancilla, Belinda, Henner, William R, Meisner, Rene, Sato, Aaron, Shah, Jalpa, Tang, Tracy, Wallace, Breanna, Wang, Min, Zhang, Chun, Kapoun, Ann M, Lewicki, John, Gurney, Austin, Hoey, Timothy

“…The Notch pathway plays an important role in both stem cell biology and cancer. Dysregulation of Notch signaling has been reported in several human tumor…”
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Water Networks Can Determine the Affinity of Ligand Binding to Proteins by Darby, John F, Hopkins, Adam P, Shimizu, Seishi, Roberts, Shirley M, Brannigan, James A, Turkenburg, Johan P, Thomas, Gavin H, Hubbard, Roderick E, Fischer, Marcus

“…Solvent organization is a key but underexploited contributor to the thermodynamics of protein–ligand recognition, with implications for ligand discovery, drug…”
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Incorporation of protein flexibility and conformational energy penalties in docking screens to improve ligand discovery by Fischer, Marcus, Coleman, Ryan G., Fraser, James S., Shoichet, Brian K.

“…Proteins fluctuate between alternative conformations, which presents a challenge for ligand discovery because such flexibility is difficult to treat…”
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Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors by Gurney, Austin, Axelrod, Fumiko, Bond, Christopher J, Cain, Jennifer, Chartier, Cecile, Donigan, Lucas, Fischer, Marcus, Chaudhari, Aurélie, Ji, May, Kapoun, Ann M, Lam, Andrew, Lazetic, Sasha, Ma, Shirley, Mitra, Satyajit, Park, In-Kyung, Pickell, Kellie, Sato, Aaron, Satyal, Sanjeev, Stroud, Michelle, Tran, Hoang, Yen, Wan-Ching, Lewicki, John, Hoey, Timothy

“…The Wnt/β-catenin pathway, which signals through the Frizzled (Fzd) receptor family and several coreceptors, has long been implicated in cancer. Here we…”
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Phenyl‐Glutarimides: Alternative Cereblon Binders for the Design of PROTACs by Min, Jaeki, Mayasundari, Anand, Keramatnia, Fatemeh, Jonchere, Barbara, Yang, Seung Wook, Jarusiewicz, Jamie, Actis, Marisa, Das, Sourav, Young, Brandon, Slavish, Jake, Yang, Lei, Li, Yong, Fu, Xiang, Garrett, Shalandus H., Yun, Mi‐Kyung, Li, Zhenmei, Nithianantham, Stanley, Chai, Sergio, Chen, Taosheng, Shelat, Anang, Lee, Richard E., Nishiguchi, Gisele, White, Stephen W., Roussel, Martine F., Potts, Patrick Ryan, Fischer, Marcus, Rankovic, Zoran

“…Targeting cereblon (CRBN) is currently one of the most frequently reported proteolysis‐targeting chimera (PROTAC) approaches, owing to favorable drug‐like…”
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One Crystal, Two Temperatures: Cryocooling Penalties Alter Ligand Binding to Transient Protein Sites by Fischer, Marcus, Shoichet, Brian K., Fraser, James S.

“…Interrogating fragment libraries by X‐ray crystallography is a powerful strategy for discovering allosteric ligands for protein targets. Cryocooling of…”
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Concepts for Hydrogen Internal Combustion Engines and Their Implications on the Exhaust Gas Aftertreatment System by Sterlepper, Stefan, Fischer, Marcus, Claßen, Johannes, Huth, Verena, Pischinger, Stefan

“…Hydrogen as carbon-free fuel is a very promising candidate for climate-neutral internal combustion engine operation. In comparison to other renewable fuels,…”
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Therapeutic Targeting of Tumor-Derived R-Spondin Attenuates β-Catenin Signaling and Tumorigenesis in Multiple Cancer Types by Chartier, Cecile, Raval, Janak, Axelrod, Fumiko, Bond, Chris, Cain, Jennifer, Dee-Hoskins, Cristina, Ma, Shirley, Fischer, Marcus M, Shah, Jalpa, Wei, Jie, Ji, May, Lam, Andrew, Stroud, Michelle, Yen, Wan-Ching, Yeung, Pete, Cancilla, Belinda, O'Young, Gilbert, Wang, Min, Kapoun, Ann M, Lewicki, John, Hoey, Timothy, Gurney, Austin

“…Deregulation of the β-catenin signaling has long been associated with cancer. Intracellular components of this pathway, including axin, APC, and β-catenin, are…”
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Temperature artifacts in protein structures bias ligand-binding predictions by Bradford, Shanshan Y. C, El Khoury, Léa, Ge, Yunhui, Osato, Meghan, Mobley, David L, Fischer, Marcus

“…X-ray crystallography is the gold standard to resolve conformational ensembles that are significant for protein function, ligand discovery, and computational…”
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Degradation of Janus kinases in CRLF2-rearranged acute lymphoblastic leukemia by Chang, Yunchao, Min, Jaeki, Jarusiewicz, Jamie A., Actis, Marisa, Yu-Chen Bradford, Shanshan, Mayasundari, Anand, Yang, Lei, Chepyala, Divyabharathi, Alcock, Lisa J., Roberts, Kathryn G., Nithianantham, Stanley, Maxwell, Dylan, Rowland, Lauren, Larsen, Randolph, Seth, Aman, Goto, Hiroaki, Imamura, Toshihiko, Akahane, Koshi, Hansen, Baranda S., Pruett-Miller, Shondra M., Paietta, Elisabeth M., Litzow, Mark R., Qu, Chunxu, Yang, Jun J., Fischer, Marcus, Rankovic, Zoran, Mullighan, Charles G.

“…CRLF2-rearranged (CRLF2r) acute lymphoblastic leukemia (ALL) accounts for more than half of Philadelphia chromosome-like (Ph-like) ALL and is associated with a…”
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Homologous ligands accommodated by discrete conformations of a buried cavity by Merski, Matthew, Fischer, Marcus, Balius, Trent E., Eidam, Oliv, Shoichet, Brian K.

“…Conformational change in protein–ligand complexes is widely modeled, but the protein accommodation expected on binding a congeneric series of ligands has…”
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RSPO3 antagonism inhibits growth and tumorigenicity in colorectal tumors harboring common Wnt pathway mutations by Fischer, Marcus M., Yeung, V. Pete, Cattaruzza, Fiore, Hussein, Rajaa, Yen, Wan-Ching, Murriel, Christopher, Evans, James W., O’Young, Gilbert, Brunner, Alayne L., Wang, Min, Cain, Jennifer, Cancilla, Belinda, Kapoun, Ann, Hoey, Timothy

“…Activating mutations in the Wnt pathway are a characteristic feature of colorectal cancer (CRC). The R-spondin (RSPO) family is a group of secreted proteins…”
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Influence of Yttria-Stabilized Zirconium Oxide Thermal Swing Coating on the Flame-Wall Interaction in Spark Ignition Engines by Fischer, Marcus, Nolte, Adrian, Wu, Xiaochao, Zhou, Dapeng, Pischinger, Stefan, Heufer, Karl Alexander, Simon, Ulrich, Vaßen, Robert

“…Future vehicle powertrain systems with internal combustion engines must achieve higher efficiencies and further reduced pollutant emissions. This will require…”
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WNT antagonists exhibit unique combinatorial antitumor activity with taxanes by potentiating mitotic cell death by Fischer, Marcus M, Cancilla, Belinda, Yeung, V Pete, Cattaruzza, Fiore, Chartier, Cecile, Murriel, Christopher L, Cain, Jennifer, Tam, Raymond, Cheng, Chieh-Yang, Evans, James W, O'Young, Gilbert, Song, Xiaomei, Lewicki, John, Kapoun, Ann M, Gurney, Austin, Yen, Wan-Ching, Hoey, Timothy

“…The WNT pathway mediates intercellular signaling that regulates cell fate in both normal development and cancer. It is widely appreciated that the WNT pathway…”
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Selective CK1α degraders exert antiproliferative activity against a broad range of human cancer cell lines by Nishiguchi, Gisele, Mascibroda, Lauren G., Young, Sarah M., Caine, Elizabeth A., Abdelhamed, Sherif, Kooijman, Jeffrey J., Miller, Darcie J., Das, Sourav, McGowan, Kevin, Mayasundari, Anand, Shi, Zhe, Barajas, Juan M., Hiltenbrand, Ryan, Aggarwal, Anup, Chang, Yunchao, Mishra, Vibhor, Narina, Shilpa, Thomas, Melvin, Loughran, Allister J., Kalathur, Ravi, Yu, Kaiwen, Zhou, Suiping, Wang, Xusheng, High, Anthony A., Peng, Junmin, Pruett-Miller, Shondra M., Daniels, Danette L., Urh, Marjeta, Shelat, Anang A., Mullighan, Charles G., Riching, Kristin M., Zaman, Guido J. R., Fischer, Marcus, Klco, Jeffery M., Rankovic, Zoran

“…Molecular-glue degraders are small molecules that induce a specific interaction between an E3 ligase and a target protein, resulting in the target proteolysis…”
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Generation of highly purified human cardiomyocytes from peripheral blood mononuclear cell-derived induced pluripotent stem cells by Fuerstenau-Sharp, Maya, Zimmermann, Martina E, Stark, Klaus, Jentsch, Nico, Klingenstein, Melanie, Drzymalski, Marzena, Wagner, Stefan, Maier, Lars S, Hehr, Ute, Baessler, Andrea, Fischer, Marcus, Hengstenberg, Christian

“…Induced pluripotent stem (iPS) cells have an enormous potential for physiological studies. A novel protocol was developed combining the derivation of iPS from…”
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The risk of infective endocarditis following interventional pulmonary valve implantation: A meta-analysis by Lehner, Anja, Haas, Nikolaus A., Dietl, Markus, Jakob, Andre, Schulze-Neick, Ingram, Dalla Pozza, Robert, Rodriguez, Silvia Fernandez, Fischer, Marcus

“…•Currently 2 types of percutaneous pulmonary valves are available for implantation.•Melody® valve (Medtronic, Dublin, Ireland) and Sapien™ valves (Edwards…”
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Blind Prediction of Charged Ligand Binding Affinities in a Model Binding Site by Rocklin, Gabriel J., Boyce, Sarah E., Fischer, Marcus, Fish, Inbar, Mobley, David L., Shoichet, Brian K., Dill, Ken A.

“…Predicting absolute protein–ligand binding affinities remains a frontier challenge in ligand discovery and design. This becomes more difficult when ionic…”
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