Search Results - "Fischer, Delphine S"

Synthesis and Evaluation of 3-(Dihydroxyboryl)benzoic Acids as d,d-Carboxypeptidase R39 Inhibitors by Inglis, Steven R, Zervosen, Astrid, Woon, Esther C. Y, Gerards, Thomas, Teller, Nathalie, Fischer, Delphine S, Luxen, André, Schofield, Christopher J

“…Penicillin binding proteins (PBPs) catalyze steps in the biosynthesis of bacterial cell walls and are the targets for the β-lactam antibiotics. Non-β-lactam…”
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Anticancer steroid sulfatase inhibitors: synthesis of a potent fluorinated second-generation agent, in vitro and in vivo activities, molecular modeling, and protein crystallography by Woo, L W Lawrence, Fischer, Delphine S, Sharland, Christopher M, Trusselle, Melanie, Foster, Paul A, Chander, Surinder K, Di Fiore, Anna, Supuran, Claudiu T, De Simone, Giuseppina, Purohit, Atul, Reed, Michael J, Potter, Barry V L

“…An improved steroid sulfatase inhibitor was prepared by replacing the N -propyl group of the second-generation steroid-like inhibitor ( 2 ) with a N…”
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Structural and mechanistic basis of penicillin-binding protein inhibition by lactivicins by Dessen, Andréa, Schofield, Christopher J, Macheboeuf, Pauline, Fischer, Delphine S, Brown, Tom, Zervosen, Astrid, Luxen, André, Joris, Bernard

“…β-lactam antibiotics, including penicillins and cephalosporins, inhibit penicillin-binding proteins (PBPs), which are essential for bacterial cell wall…”
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E-Ring Modified Steroids as Novel Potent Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1 by Fischer, Delphine S, Allan, Gillian M, Bubert, Christian, Vicker, Nigel, Smith, Andrew, Tutill, Helena J, Purohit, Atul, Wood, Lynn, Packham, Graham, Mahon, Mary F, Reed, Michael J, Potter, Barry V. L

“…17β-Hydroxysteroid dehydrogenases (17β-HSDs) are an important class of steroidogenic enzymes that regulate the bioavailability of active estrogens and…”
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Modification of Estrone at the 6, 16, and 17 Positions:  Novel Potent Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1 by Allan, Gillian M, Lawrence, Harshani R, Cornet, Josephine, Bubert, Christian, Fischer, Delphine S, Vicker, Nigel, Smith, Andrew, Tutill, Helena J, Purohit, Atul, Day, Joanna M, Mahon, Mary F, Reed, Michael J, Potter, Barry V. L

“…The 17β-hydroxysteroid dehydrogenases (17β-HSDs) catalyze the interconversion between the oxidized and reduced forms of androgens and estrogens at the 17…”
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D-Ring Modified Estrone Derivatives as Novel Potent Inhibitors of Steroid Sulfatase by Fischer, Delphine S, Woo, L.W.Lawrence, Mahon, Mary F, Purohit, Atul, Reed, Michael J, Potter, Barry V.L

“…A series of novel D-ring modified derivatives of estrone was synthesized and tested as inhibitors of steroid sulfatase (STS). The steroidal D-ring was cleaved…”
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Novel D-ring modified steroid derivatives as potent, non-estrogenic, steroid sulfatase inhibitors with in vivo activity by Fischer, Delphine S., Chander, Surinder K., Woo, L.W.Lawrence, Fenton, Janine C., Purohit, Atul, Reed, Michael J., Potter, Barry V.L.

“…In pursuit of novel steroid sulfatase (STS) inhibitors devoid of estrogenicity, several D-ring modified steroid derivatives were synthesised. In vitro…”
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Nature Chemical Biology by Macheboeuf, Pauline, Fischer, Delphine S, Brown, Tom Jr, Zervosen, Astrid, Luxen, André, Joris, Bernard, Dessen, Andréa, Schofield, Christopher J

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Modification of estrone at the 6, 16, and 17 positions: novel potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 by Allan, Gillian M, Lawrence, Harshani R, Cornet, Josephine, Bubert, Christian, Fischer, Delphine S, Vicker, Nigel, Smith, Andrew, Tutill, Helena J, Purohit, Atul, Day, Joanna M, Mahon, Mary F, Reed, Michael J, Potter, Barry V L

“…The 17beta-hydroxysteroid dehydrogenases (17beta-HSDs) catalyze the interconversion between the oxidized and reduced forms of androgens and estrogens at the 17…”
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Modification of estrone at the 6, 16, and 17 positions : Novel potent inhibitors of 17/?-hydroxysteroid dehydrogenase type 1 by ALLAN, Gillian M, LAWRENCE, Harshani R, MAHON, Mary F, REED, Michael J, POTTER, Barry V. L, CORNET, Josephine, BUBERT, Christian, FISCHER, Delphine S, VICKER, Nigel, SMITH, Andrew, TUTILL, Helena J, PUROHIT, Atul, DAY, Joanna M

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E-ring modified steroids as novel potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 by Fischer, Delphine S, Allan, Gillian M, Bubert, Christian, Vicker, Nigel, Smith, Andrew, Tutill, Helena J, Purohit, Atul, Wood, Lynn, Packham, Graham, Mahon, Mary F, Reed, Michael J, Potter, Barry V L

“…17beta-Hydroxysteroid dehydrogenases (17beta-HSDs) are an important class of steroidogenic enzymes that regulate the bioavailability of active estrogens and…”
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Novel inhibitors of steroidogenesis for the treatment of hormone-dependent breast cancer by Fischer, Delphine S

“…Inhibition of steroidogenic enzymes, which are involved in the biosynthesis of active estrogens, represents an attractive approach to treating…”
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Novel inhibitors of steroidogenesis for the treatment of hormone-dependent breast cancer by Fischer, Delphine S

“…Inhibition of steroidogenic enzymes, which are involved in the biosynthesis of active estrogens, represents an attractive approach to treating…”
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