Search Results - "Fischer, Delaney K"
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Cocaine regulation of Nr4a1 chromatin bivalency and mRNA in male and female mice
Published in Scientific reports (21-09-2022)“…Cocaine epigenetically regulates gene expression via changes in histone post-translational modifications (HPTMs). We previously found that the immediate early…”
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Cell-type specific profiling of histone post-translational modifications in the adult mouse striatum
Published in Nature communications (13-12-2022)“…Epigenetic gene regulation in the heterogeneous brain remains challenging to decipher with current strategies. Bulk tissue analysis from pooled subjects…”
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Author Correction: Cell-type specific profiling of histone post-translational modifications in the adult mouse striatum
Published in Nature communications (22-02-2023)Get full text
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Rescue of Learning and Memory Deficits in the Human Nonsyndromic Intellectual Disability Cereblon Knock-Out Mouse Model by Targeting the AMP-Activated Protein Kinase-mTORC1 Translational Pathway
Published in The Journal of neuroscience (14-03-2018)“…A homozygous nonsense mutation in the cereblon ( ) gene results in autosomal recessive, nonsyndromic intellectual disability that is devoid of other phenotypic…”
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Extinction of Contextual Cocaine Memories Requires Cav1.2 within D1R-Expressing Cells and Recruits Hippocampal Cav1.2-Dependent Signaling Mechanisms
Published in The Journal of neuroscience (06-12-2017)“…Exposure to cocaine-associated contextual cues contributes significantly to relapse. Extinction of these contextual associations, which involves a new form of…”
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6
Contribution of D1R-expressing neurons of the dorsal dentate gyrus and Cav1.2 channels in extinction of cocaine conditioned place preference
Published in Neuropsychopharmacology (New York, N.Y.) (01-08-2020)“…Cocaine-associated contextual cues can trigger relapse behavior by recruiting the hippocampus. Extinction of cocaine-associated contextual memories can reduce…”
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7
Cav1.2 channels mediate persistent chronic stress-induced behavioral deficits that are associated with prefrontal cortex activation of the p25/Cdk5-glucocorticoid receptor pathway
Published in Neurobiology of stress (01-12-2017)“…Chronic stress is known to precipitate and exacerbate neuropsychiatric symptoms, and exposure to stress is particularly pathological in individuals with…”
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Cocaine- and stress-primed reinstatement of drug-associated memories elicit differential behavioral and frontostriatal circuit activity patterns via recruitment of L-type Ca2+ channels
Published in Molecular psychiatry (09-09-2019)“…Cocaine-associated memories are critical drivers of relapse in cocaine-dependent individuals that can be evoked by exposure to cocaine or stress. Whether these…”
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9
Chromatin-mediated alternative splicing regulates cocaine-reward behavior
Published in Neuron (Cambridge, Mass.) (15-09-2021)“…Neuronal alternative splicing is a key gene regulatory mechanism in the brain. However, the spliceosome machinery is insufficient to fully specify splicing…”
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10
Altered reward sensitivity in female offspring of cocaine-exposed fathers
Published in Behavioural brain research (14-08-2017)“…•Cocaine-sired female offspring show altered locomotor sensitivity to psychostimulants and rewarding effects to sucrose•Cocaine-sired female offspring show…”
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Cacna1c in the Prefrontal Cortex Regulates Depression-Related Behaviors via REDD1
Published in Neuropsychopharmacology (New York, N.Y.) (01-09-2017)“…The CACNA1C gene that encodes the L-type Ca channel (LTCC) Ca 1.2 subunit has emerged as a candidate risk gene for multiple neuropsychiatric disorders…”
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12
Proprioceptive stimuli and habit formation: Interresponse time mediated behavior in CD-1 mice
Published in Behavioural processes (01-05-2018)“…•IRTs come to control sequential choice behavior in CD-1 mice.•Subjects emitted IRT mediated switching behavior matching the reinforcement…”
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Correction: Cocaine- and stress-primed reinstatement of drug-associated memories elicit differential behavioral and frontostriatal circuit activity patterns via recruitment of L-type Ca2+ channels
Published in Molecular psychiatry (01-10-2020)“…A correction to this paper has been published and can be accessed via a link at the top of the paper…”
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14
A dual-virus strategy for the deletion of cacan1c within the prelimbic to nucleus accumbens core projection
Published in Molecular psychiatry (01-10-2020)Get full text
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15
Extinction of Contextual Cocaine Memories Requires Ca v 1.2 within D1R-Expressing Cells and Recruits Hippocampal Ca v 1.2-Dependent Signaling Mechanisms
Published in The Journal of neuroscience (06-12-2017)“…Exposure to cocaine-associated contextual cues contributes significantly to relapse. Extinction of these contextual associations, which involves a new form of…”
Get full text
Journal Article -
16
Ca v 1.2 channels mediate persistent chronic stress-induced behavioral deficits that are associated with prefrontal cortex activation of the p25/Cdk5-glucocorticoid receptor pathway
Published in Neurobiology of stress (01-12-2017)“…Chronic stress is known to precipitate and exacerbate neuropsychiatric symptoms, and exposure to stress is particularly pathological in individuals with…”
Get full text
Journal Article -
17
Cocaine- and stress-primed reinstatement of drug-associated memories elicit differential behavioral and frontostriatal circuit activity patterns via recruitment of L-type Ca.sup.2+ channels
Published in Molecular psychiatry (01-10-2020)“…Cocaine-associated memories are critical drivers of relapse in cocaine-dependent individuals that can be evoked by exposure to cocaine or stress. Whether these…”
Get full text
Journal Article -
18
Correction: Cocaine- and stress-primed reinstatement of drug-associated memories elicit differential behavioral and frontostriatal circuit activity patterns via recruitment of L-type Ca.sup.2+ channels
Published in Molecular psychiatry (01-10-2020)“…A correction to this paper has been published and can be accessed via a link at the top of the paper…”
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Journal Article -
19
Extinction of Contextual Cocaine Memories Requires Ca^sub v^1.2 within D1R-Expressing Cells and Recruits Hippocampal Ca^sub v^1.2-Dependent Signaling Mechanisms
Published in The Journal of neuroscience (06-12-2017)“…Exposure to cocaine-associated contextual cues contributes significantly to relapse. Extinction of these contextual associations, which involves a new form of…”
Get full text
Journal Article -
20
Contribution of D1R-expressing neurons of the dorsal dentate gyrus and Ca v 1.2 channels in extinction of cocaine conditioned place preference
Published in Neuropsychopharmacology (New York, N.Y.) (01-08-2020)“…Cocaine-associated contextual cues can trigger relapse behavior by recruiting the hippocampus. Extinction of cocaine-associated contextual memories can reduce…”
Get full text
Journal Article