Search Results - "Fischer, David D"
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Escherichia coli Nissle 1917 administered as a dextranomar microsphere biofilm enhances immune responses against human rotavirus in a neonatal malnourished pig model colonized with human infant fecal microbiota
Published in PloS one (16-02-2021)“…Human rotavirus (HRV) is a leading cause of diarrhea in children. It causes significant morbidity and mortality, especially in low- and middle-income countries…”
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Escherichia coli Nissle 1917 protects gnotobiotic pigs against human rotavirus by modulating pDC and NK‐cell responses
Published in European journal of immunology (01-10-2016)“…Lactobacillus rhamnosus GG (LGG), a gram‐positive lactic acid bacterium, is one of the most widely used probiotics; while fewer gram‐negative probiotics…”
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Protein deficiency reduces efficacy of oral attenuated human rotavirus vaccine in a human infant fecal microbiota transplanted gnotobiotic pig model
Published in Vaccine (08-10-2018)“…•Protein deficiency impacted immunity and reduced human RV vaccine efficacy.•Human infant fecal microbiota exacerbated the negative effects of protein…”
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Unraveling the Differences between Gram-Positive and Gram-Negative Probiotics in Modulating Protective Immunity to Enteric Infections
Published in Frontiers in immunology (27-03-2017)“…The role of intestinal microbiota and probiotics in prevention and treatment of infectious diseases, including diarrheal diseases in children and animal…”
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Impact of nutrition and rotavirus infection on the infant gut microbiota in a humanized pig model
Published in BMC gastroenterology (22-06-2018)“…Human rotavirus (HRV) is a major cause of viral gastroenteritis in infants; particularly in developing countries where malnutrition is prevalent. Malnutrition…”
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Malnutrition Decreases Antibody Secreting Cell Numbers Induced by an Oral Attenuated Human Rotavirus Vaccine in a Human Infant Fecal Microbiota Transplanted Gnotobiotic Pig Model
Published in Frontiers in immunology (14-02-2020)“…Human rotavirus (HRV) is a leading cause of morbidity and mortality in children, especially in developing countries. Malnutrition is prevalent in these…”
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Escherichia coli Nissle 1917 Enhances Innate and Adaptive Immune Responses in a Ciprofloxacin-Treated Defined-Microbiota Piglet Model of Human Rotavirus Infection
Published in mSphere (31-03-2021)“…Human rotavirus (HRV) infection is a major cause of gastroenteritis in children worldwide. Broad-spectrum antibiotic-induced intestinal microbial imbalance and…”
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Escherichia coli Nissle 1917 Enhances Efficacy of Oral Attenuated Human Rotavirus Vaccine in a Gnotobiotic Piglet Model
Published in Vaccines (Basel) (06-01-2022)“…Human rotavirus (HRV) infection is a major cause of viral gastroenteritis in young children worldwide. Current oral vaccines perform poorly in developing…”
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Protein Malnutrition Modifies Innate Immunity and Gene Expression by Intestinal Epithelial Cells and Human Rotavirus Infection in Neonatal Gnotobiotic Pigs
Published in mSphere (01-03-2017)“…Malnutrition affects millions of children in developing countries, compromising immunity and contributing to increased rates of death from infectious diseases…”
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Protein Malnutrition Alters Tryptophan and Angiotensin-Converting Enzyme 2 Homeostasis and Adaptive Immune Responses in Human Rotavirus-Infected Gnotobiotic Pigs with Human Infant Fecal Microbiota Transplant
Published in Clinical and vaccine immunology (01-08-2017)“…Malnutrition leads to increased morbidity and is evident in almost half of all deaths in children under the age of 5 years. Mortality due to rotavirus diarrhea…”
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Comparative In Vitro and In Vivo Studies of Porcine Rotavirus G9P[13] and Human Rotavirus Wa G1P[8]
Published in Journal of virology (01-01-2016)“…The changing epidemiology of group A rotavirus (RV) strains in humans and swine, including emerging G9 strains, poses new challenges to current vaccines. In…”
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Tissue-specific mRNA expression profiles of porcine Toll-like receptors at different ages in germ-free and conventional pigs
Published in Veterinary immunology and immunopathology (01-03-2016)“…•Systematically assess porcine TLRs 1–10mRNA expression profiles.•Splenic and ileal mononuclear cells have different TLR expression profiles.•Colostrum/breast…”
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Effects of Escherichia coli Nissle 1917 and Ciprofloxacin on small intestinal epithelial cell mRNA expression in the neonatal piglet model of human rotavirus infection
Published in Gut pathogens (13-12-2016)“…We evaluated the effects of the probiotic Nissle 1917 (EcN) and the antibiotic Ciprofloxacin (Cipro) on mRNA expression of intestinal epithelial cells (IEC) in…”
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Evaluation of Tail Biopsy Collection in Laboratory Mice (Mus musculus): Vertebral Ossification, DNA Quantity, and Acute Behavioral Responses
Published in Journal of the American Association for Laboratory Animal Science (01-11-2008)“…A preferred method to genotype genetically engineered mice is through collection of distal tail tissue (tail biopsy) followed by DNA isolation. Currently,…”
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Escherichia coli Nissle 1917 protects gnotobiotic pigs against human rotavirus by modulating plasmacytoid dendritic and natural killer cell responses
Published in European journal of immunology (11-08-2016)“…Gram-positive lactic acid-producing bacteria including Lactobacillus rhamnosus GG (LGG) are commonly used as probiotics, while fewer gram-negative probiotics…”
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Membrane-bound immunomodulators as adjuvants in a cell culture-based avian influenza vaccine
Published 01-01-2012“…Inactivated viral vaccines often generate suboptimal immune responses. Adjuvants are incorporated into vaccines to increase their immunogenicity, however…”
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Dissertation -
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IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position paper
Published in The World Allergy Organization journal (01-02-2020)“…Currently, testing for immunoglobulin E (IgE) sensitization is the cornerstone of diagnostic evaluation in suspected allergic conditions. This review provides…”
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Membrane-bound immunomodulators as adjuvants in a cell culture-based avian influenza vaccine
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Dissertation -
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Photopsias: A Key to Diagnosis
Published in Ophthalmology (Rochester, Minn.) (01-10-2015)“…Purpose To assess the character and cause of photopsias in vitreoretinal patients. Design Cross-sectional study. Participants A total of 169 consecutive…”
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