Search Results - "Fischer, Baptiste"
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Fructose-1,6-bisphosphate couples glycolytic flux to activation of Ras
Published in Nature communications (13-10-2017)“…Yeast and cancer cells share the unusual characteristic of favoring fermentation of sugar over respiration. We now reveal an evolutionary conserved mechanism…”
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2
Megabodies expand the nanobody toolkit for protein structure determination by single-particle cryo-EM
Published in Nature methods (01-01-2021)“…Nanobodies are popular and versatile tools for structural biology. They have a compact single immunoglobulin domain organization, bind target proteins with…”
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3
Allosteric nanobodies to study the interactions between SOS1 and RAS
Published in Nature communications (23-07-2024)“…Protein-protein interactions (PPIs) are central in cell metabolism but research tools for the structural and functional characterization of these PPIs are…”
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Skywalker-TBC1D24 has a lipid-binding pocket mutated in epilepsy and required for synaptic function
Published in Nature structural & molecular biology (26-09-2016)Get full text
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5
Development of a Quartz-MEMS Resonator
Published in 2023 Joint Conference of the European Frequency and Time Forum and IEEE International Frequency Control Symposium (EFTF/IFCS) (15-05-2023)“…SummaryThis paper presents a miniaturized high Q-factor Thickness Shear Mode Resonator (TSMR), manufacture collectively thanks to the Deep Reactive Ion Etching…”
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Conference Proceeding -
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Skywalker-TBC1D24 has a lipid-binding pocket mutated in epilepsy and required for synaptic function
Published in Nature structural & molecular biology (01-11-2016)“…Structural, biochemical and functional analyses elucidate the mechanisms by which mutations in the TBC1D24 gene interfere with protein function, thus causing…”
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TBC1D24-TLDc-related epilepsy exercise-induced dystonia: rescue by antioxidants in a disease model
Published in Brain (London, England : 1878) (01-08-2019)“…Genetic mutations in TBC1D24 have been associated with multiple phenotypes, with epilepsy being the main clinical manifestation. The TBC1D24 protein consists…”
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Nanobody Loop Mimetics Enhance Son of Sevenless 1‐Catalyzed Nucleotide Exchange on RAS
Published in Angewandte Chemie International Edition (12-06-2023)“…RAS proteins control various intracellular signaling networks. Mutations at specific locations were shown to stabilize their active guanosine triphosphate…”
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9
An improved yeast surface display platform for the screening of nanobody immune libraries
Published in Scientific reports (23-01-2019)“…Fusions to the C-terminal end of the Aga2p mating adhesion of Saccharomyces cerevisiae have been used in many studies for the selection of affinity reagents by…”
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10
Yeast and Cancer: Common Mechanism Underlying Activation of Ras by Glycolytic Flux
Published in The FASEB journal (01-04-2018)“…Ras proteins are small guanosine triphosphatases (GTPases), which function as on‐off binary switches for diverse signaling pathways. Nearly 30% of human tumors…”
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11
Nanobody Loop Mimetics Enhance Son of Sevenless 1‐Catalyzed Nucleotide Exchange on RAS
Published in Angewandte Chemie (12-06-2023)“…RAS proteins control various intracellular signaling networks. Mutations at specific locations were shown to stabilize their active guanosine triphosphate…”
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Journal Article -
12
Catalytic properties of a bacterial acylating acetaldehyde dehydrogenase: Evidence for several active oligomeric states and coenzyme A activation upon binding
Published in Chemico-biological interactions (25-02-2013)“…► The catalytic properties of an acylating aldehyde dehydrogenase are investigated. ► The monomeric form of this aldehyde dehydrogenase is shown to be fully…”
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