Search Results - "Fischbach, Gerald D."

The Simons Simplex Collection: A Resource for Identification of Autism Genetic Risk Factors by Fischbach, Gerald D., Lord, Catherine

“…In an effort to identify de novo genetic variants that contribute to the overall risk of autism, the Simons Foundation Autism Research Initiative (SFARI) has…”
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Deficiency of Dgcr8, a gene disrupted by the 22q11.2 microdeletion, results in altered short-term plasticity in the prefrontal cortex by Fénelon, Karine, Mukai, Jun, Xu, Bin, Hsu, Pei-Ken, Drew, Liam J, Karayiorgou, Maria, Fischbach, Gerald D, MacDermott, Amy B, Gogos, Joseph A

“…Individuals with 22q11.2 microdeletions have cognitive and behavioral impairments and the highest known genetic risk for developing schizophrenia. One gene…”
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The pattern of cortical dysfunction in a mouse model of a schizophrenia-related microdeletion by Fénelon, Karine, Xu, Bin, Lai, Cora S, Mukai, Jun, Markx, Sander, Stark, Kimberly L, Hsu, Pei-Ken, Gan, Wen-Biao, Fischbach, Gerald D, MacDermott, Amy B, Karayiorgou, Maria, Gogos, Joseph A

“…We used a mouse model of the schizophrenia-predisposing 22q11.2 microdeletion to evaluate how this genetic lesion affects cortical neural circuits at the…”
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Jim Simons (1938–2024) by Fischbach, Gerald D.

“…What follows is not a detailed biography of Jim Simons, whose diversity of talents and activities as a mathematician, educator, administrator, life scientist,…”
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ARIA : A neuromuscular junction neuregulin by FISCHBACH, G. D, ROSEN, K. M

“…Motor neurons influence the expression and the distribution of acetylcholine receptors in skeletal muscle. Molecules that mediate this carefully choreographed…”
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Neuregulin-1 increases the proliferation of neuronal progenitors from embryonic neural stem cells by Liu, Yun, Ford, Byron D., Mann, Mary Anne, Fischbach, Gerald D.

“…Neuregulins are a family of proteins expressed in the developing brain and in brain regions that continue to undergo neurogenesis in adult animals. We…”
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The Agrin/MuSK Signaling Pathway Is Spatially Segregated from the Neuregulin/ErbB Receptor Signaling Pathway at the Neuromuscular Junction by Trinidad, Jonathan C, Fischbach, Gerald D, Cohen, Jonathan B

“…The neuregulin/erbB receptor and agrin/MuSK pathways are critical for communication between the nerve, muscle, and Schwann cell that establishes the precise…”
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Neuregulin and ErbB receptor signaling pathways in the nervous system by Buonanno, Andres, Fischbach, Gerald D

“…The neuregulins are a complex family of factors that perform many functions during neural development. Recent experiments have shown that neuregulins promote…”
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NRG1 and Synaptic Function in the CNS by Fischbach, Gerald D.

“…Recent genetic evidence indicates that neuregulin 1 (NRG1) and its receptor erbB4 may be susceptibility genes in schizophrenia, but their function in CNS…”
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Is there concordance in attitudes and beliefs between parents and scientists about autism spectrum disorder? by Fischbach, Ruth L, Harris, Mark J, Ballan, Michelle S, Fischbach, Gerald D, Link, Bruce G

“…There is no reported investigation comparing concordance in attitudes and beliefs about autism spectrum disorder between parents of children with autism…”
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An acute effect of neuregulin 1 beta to suppress alpha 7-containing nicotinic acetylcholine receptors in hippocampal interneurons by Chang, Qing, Fischbach, Gerald D

“…We examined rapid effects of neuregulin (NRG) on nicotinic acetylcholine (ACh) receptors in interneurons located in the stratum radiatum of the hippocampus…”
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Stem cells: science, policy, and ethics by Fischbach, Gerald D, Fischbach, Ruth L

“…Human embryonic stem cells offer the promise of a new regenerative medicine in which damaged adult cells can be replaced with new cells. Research is needed to…”
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Neuregulins Increase α7 Nicotinic Acetylcholine Receptors and Enhance Excitatory Synaptic Transmission in GABAergic Interneurons of the Hippocampus by Liu, Yun, Ford, Byron, Mann, Mary Anne, Fischbach, Gerald D.

“…Neuregulins are highly expressed in the CNS, especially in cholinergic neurons. We have examined the effect of neuregulin on nicotinic acetylcholine receptors…”
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The best of times, the worst of times for psychiatric disease by Karayiorgou, Maria, Flint, Jonathan, Gogos, Joseph A, Malenka, Robert C

“…As long-awaited advances in psychiatric genetics begin to materialize in force, promising to steer us safely to the best of times in psychiatric disease…”
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A Role for the Acetylcholine Receptor-Inducing Protein ARIA in Oligodendrocyte Development by Vartanian, T, Corfas, G, Li, Y, Fischbach, G D, Stefansson, K

“…ARIA acetylcholine receptor-inducing activity protein, is a member of a family of ligands that includes the Neu differentiation factor, heregulin, and glial…”
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Activity-dependent modulation of synaptic AMPA receptor accumulation by O'Brien, R J, Kamboj, S, Ehlers, M D, Rosen, K R, Fischbach, G D, Huganir, R L

“…Both theoretical and experimental work have suggested that central neurons compensate for changes in excitatory synaptic input in order to maintain a…”
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Schizophrenia: signals from the other side by Fischbach, Gerald D

“…Animal models of schizophrenia are incomplete, and human brain tissue has been difficult to study. Results from postmortem human tissue begin to overcome these…”
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Neuregulin Expression at Neuromuscular Synapses Is Modulated by Synaptic Activity and Neurotrophic Factors by Loeb, Jeffrey A, Hmadcha, Abdelkrim, Fischbach, Gerald D, Land, Susan J, Zakarian, Vaagn L

“…The proper formation of neuromuscular synapses requires ongoing synaptic activity that is translated into complex structural changes to produce functional…”
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Maintenance of Acetylcholine Receptor Number by Neuregulins at the Neuromuscular Junction in Vivo by Sandrock, Alfred W., Dryer, Stuart E., Rosen, Kenneth M., Gozani, Shai N., Kramer, Rainer, Theill, Lars E., Fischbach, Gerald D.

“…ARIA (for acetylcholine receptor-inducing activity), a protein purified on the basis of its ability to stimulate acetylcholine receptor (AChR) synthesis in…”
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Neuregulin Effect on Quantal Content Dissociated From Effect on Miniature Endplate Potential Amplitude by Mann, Mary Anne, Das, Saumya, Zhang, Jinghua, Wagner, Meredith, Fischbach, Gerald D

“…1 Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, New York; and 2 Department of Cardiac Arrhythmia,…”
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