Search Results - "Firth, Andrew"

A putative new SARS-CoV protein, 3c, encoded in an ORF overlapping ORF3a by Firth, Andrew E

“…Identification of the full complement of genes in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a crucial step towards gaining a fuller…”
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Non-canonical translation in RNA viruses by FIRTH, Andrew E, BRIERLEY, Ian

“…Viral protein synthesis is completely dependent upon the translational machinery of the host cell. However, many RNA virus transcripts have marked structural…”
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Mapping overlapping functional elements embedded within the protein-coding regions of RNA viruses by Firth, Andrew E

“…Identification of the full complement of genes and other functional elements in any virus is crucial to fully understand its molecular biology and guide the…”
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Insect-specific flaviviruses: a systematic review of their discovery, host range, mode of transmission, superinfection exclusion potential and genomic organization by Blitvich, Bradley J, Firth, Andrew E

“…There has been a dramatic increase in the number of insect-specific flaviviruses (ISFs) discovered in the last decade. Historically, these viruses have…”
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High-Resolution Analysis of Coronavirus Gene Expression by RNA Sequencing and Ribosome Profiling by Irigoyen, Nerea, Firth, Andrew E, Jones, Joshua D, Chung, Betty Y-W, Siddell, Stuart G, Brierley, Ian

“…Members of the family Coronaviridae have the largest genomes of all RNA viruses, typically in the region of 30 kilobases. Several coronaviruses, such as Severe…”
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A hidden gene in astroviruses encodes a viroporin by Lulla, Valeria, Firth, Andrew E.

“…Human astroviruses are small non-enveloped viruses with positive-sense single-stranded RNA genomes. Astroviruses cause acute gastroenteritis in children…”
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Ribosomal frameshifting and transcriptional slippage: From genetic steganography and cryptography to adventitious use by Atkins, John F, Loughran, Gary, Bhatt, Pramod R, Firth, Andrew E, Baranov, Pavel V

“…Genetic decoding is not 'frozen' as was earlier thought, but dynamic. One facet of this is frameshifting that often results in synthesis of a C-terminal region…”
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Identification of RNA Virus–Derived RdRp Sequences in Publicly Available Transcriptomic Data Sets by Olendraite, Ingrida, Brown, Katherine, Firth, Andrew E

“…Abstract RNA viruses are abundant and highly diverse and infect all or most eukaryotic organisms. However, only a tiny fraction of the number and diversity of…”
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Manipulation of the unfolded protein response: A pharmacological strategy against coronavirus infection by Echavarría-Consuegra, Liliana, Cook, Georgia M, Busnadiego, Idoia, Lefèvre, Charlotte, Keep, Sarah, Brown, Katherine, Doyle, Nicole, Dowgier, Giulia, Franaszek, Krzysztof, Moore, Nathan A, Siddell, Stuart G, Bickerton, Erica, Hale, Benjamin G, Firth, Andrew E, Brierley, Ian, Irigoyen, Nerea

“…Coronavirus infection induces the unfolded protein response (UPR), a cellular signalling pathway composed of three branches, triggered by unfolded proteins in…”
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Detection of a fourth orbivirus non-structural protein by Belhouchet, Mourad, Mohd Jaafar, Fauziah, Firth, Andrew E, Grimes, Jonathan M, Mertens, Peter P C, Attoui, Houssam

“…The genus Orbivirus includes both insect and tick-borne viruses. The orbivirus genome, composed of 10 segments of dsRNA, encodes 7 structural proteins…”
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A Review of Flaviviruses that Have No Known Arthropod Vector by Blitvich, Bradley J, Firth, Andrew E

“…Most viruses in the genus are horizontally transmitted between hematophagous arthropods and vertebrate hosts, but some are maintained in arthropod- or…”
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New insights into flavivirus evolution, taxonomy and biogeographic history, extended by analysis of canonical and alternative coding sequences by Moureau, Gregory, Cook, Shelley, Lemey, Philippe, Nougairede, Antoine, Forrester, Naomi L, Khasnatinov, Maxim, Charrel, Remi N, Firth, Andrew E, Gould, Ernest A, de Lamballerie, Xavier

“…To generate the most diverse phylogenetic dataset for the flaviviruses to date, we determined the genomic sequences and phylogenetic relationships of 14…”
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Discovery of a Small Non-AUG-Initiated ORF in Poleroviruses and Luteoviruses That Is Required for Long-Distance Movement by Smirnova, Ekaterina, Firth, Andrew E, Miller, W Allen, Scheidecker, Danièle, Brault, Véronique, Reinbold, Catherine, Rakotondrafara, Aurélie M, Chung, Betty Y-W, Ziegler-Graff, Véronique

“…Viruses in the family Luteoviridae have positive-sense RNA genomes of around 5.2 to 6.3 kb, and they are limited to the phloem in infected plants. The…”
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Psychometric properties of patient-reported outcome measures assessing recovery from hand fractures: a systematic review by Mousoulis, Christos, Firth, Andrew D, Marson, Alanna, Gagnier, Joel J

“…To extensively review Patient Reported Outcome Measures (PROMs) used to assess outcomes in persons with hand fractures in terms of their psychometric…”
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CIAlign: A highly customisable command line tool to clean, interpret and visualise multiple sequence alignments by Tumescheit, Charlotte, Firth, Andrew E, Brown, Katherine

“…Throughout biology, multiple sequence alignments (MSAs) form the basis of much investigation into biological features and relationships. These alignments are…”
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Retapamulin-Assisted Ribosome Profiling Reveals the Alternative Bacterial Proteome by Meydan, Sezen, Marks, James, Klepacki, Dorota, Sharma, Virag, Baranov, Pavel V., Firth, Andrew E., Margus, Tōnu, Kefi, Amira, Vázquez-Laslop, Nora, Mankin, Alexander S.

“…The use of alternative translation initiation sites enables production of more than one protein from a single gene, thereby expanding the cellular proteome…”
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Turnip Mosaic Virus Transcriptional Slippage Dynamics and Distribution in RNA Subpopulations by Kärblane, Kairi, Firth, Andrew E, Olspert, Allan

“…Potyviruses comprise the largest and most important group of plant positive-strand RNA viruses. The potyviral cell-to-cell movement protein P3N-PIPO is…”
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Novel virus discovery and genome reconstruction from field RNA samples reveals highly divergent viruses in dipteran hosts by Cook, Shelley, Chung, Betty Y-W, Bass, David, Moureau, Gregory, Tang, Shuoya, McAlister, Erica, Culverwell, C Lorna, Glücksman, Edvard, Wang, Hui, Brown, T David K, Gould, Ernest A, Harbach, Ralph E, de Lamballerie, Xavier, Firth, Andrew E

“…We investigated whether small RNA (sRNA) sequenced from field-collected mosquitoes and chironomids (Diptera) can be used as a proxy signature of viral…”
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A swine arterivirus deubiquitinase stabilizes two major envelope proteins and promotes production of viral progeny by Guo, Rui, Yan, Xingyu, Li, Yanhua, Cui, Jin, Misra, Saurav, Firth, Andrew E, Snijder, Eric J, Fang, Ying

“…Arteriviruses are enveloped positive-strand RNA viruses that assemble and egress using the host cell's exocytic pathway. In previous studies, we demonstrated…”
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A novel ilarvirus protein CP-RT is expressed via stop codon readthrough and suppresses RDR6-dependent RNA silencing by Lukhovitskaya, Nina, Brown, Katherine, Hua, Lei, Pate, Adrienne E, Carr, John P, Firth, Andrew E

“…Ilarviruses are a relatively understudied but important group of plant RNA viruses that includes a number of crop pathogens. Their genomes comprise three RNA…”
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