Search Results - "Firpo, Meri T"

Activin A Maintains Pluripotency of Human Embryonic Stem Cells in the Absence of Feeder Layers by Beattie, Gillian M., Lopez, Ana D., Bucay, Nathan, Hinton, Andrew, Firpo, Meri T., King, Charles C., Hayek, Alberto

“…To date, all human embryonic stem cells (hESCs) available for research require unidentified soluble factors secreted from feeder layers to maintain the…”
Get full text

Report of the International Stem Cell Banking Initiative Workshop Activity: Current Hurdles and Progress in Seed‐Stock Banking of Human Pluripotent Stem Cells by Kim, Jung‐Hyun, Kurtz, Andreas, Yuan, Bao‐Zhu, Zeng, Fanyi, Lomax, Geoff, Loring, Jeanne F., Crook, Jeremy, Ju, Ji Hyeon, Clarke, Laura, Inamdar, Maneesha S., Pera, Martin, Firpo, Meri T., Sheldon, Michael, Rahman, Nafees, O'Shea, Orla, Pranke, Patricia, Zhou, Qi, Isasi, Rosario, Rungsiwiwut, Ruttachuk, Kawamata, Shin, Oh, Steve, Ludwig, Tenneille, Masui, Tohru, Novak, Thomas J., Takahashi, Tsuneo, Fujibuchi, Wataru, Koo, Soo Kyung, Stacey, Glyn N.

“…This article summarizes the recent activity of the International Stem Cell Banking Initiative (ISCBI) held at the California Institute for Regenerative…”
Get full text

Maintenance of Pluripotency in Human Embryonic Stem Cells Is STAT3 Independent by Humphrey, Rohan K., Beattie, Gillian M., Lopez, Ana D., Bucay, Nathan, King, Charles C., Firpo, Meri T., Rose‐John, Stefan, Hayek, Alberto

“…The preservation of “stemness” in mouse embryonic stem (mES) cells is maintained through a signal transduction pathway that requires the gp130 receptor, the…”
Get full text

Hydrogels as artificial matrices for human embryonic stem cell self-renewal by Li, Ying J., Chung, Eugene H., Rodriguez, Ryan T., Firpo, Meri T., Healy, Kevin E.

“…Human embryonic stem cells (hESCs) have the potential to differentiate into all cell types in the body and hold great promise for regenerative medicine;…”
Get full text

Hypoxia within subcutaneously implanted macroencapsulation devices limits the viability and functionality of densely loaded islets by Einstein, Samuel A, Steyn, Leah V, Weegman, Bradley P, Suszynski, Thomas M, Sambanis, Athanassios, O'Brien, Timothy D, Avgoustiniatos, Efstathios S, Firpo, Meri T, Graham, Melanie L, Janecek, Jody, Eberly, Lynn E, Garwood, Michael, Putnam, Charles W, Papas, Klearchos K

“…Subcutaneous macroencapsulation devices circumvent disadvantages of intraportal islet therapy. However, a curative dose of islets within reasonably sized…”
Get full text

Polybromo protein BAF180 functions in mammalian cardiac chamber maturation by Wang, Zhong, Zhai, Weiguo, Richardson, James A, Olson, Eric N, Meneses, Juanito J, Firpo, Meri T, Kang, Chulho, Skarnes, William C, Tjian, Robert

“…BAF and PBAF are two related mammalian chromatin remodeling complexes essential for gene expression and development. PBAF, but not BAF, is able to potentiate…”
Get full text

Human Pumilio-2 Is Expressed in Embryonic Stem Cells and Germ Cells and Interacts with DAZ (Deleted in AZoospermia) and DAZ-Like Proteins by Moore, Frederick L., Jaruzelska, Jadwiga, Fox, Mark S., Urano, Jun, Firpo, Meri T., Turek, Paul J., Dorfman, David M., Renee A. Reijo Pera

“…Early in development, a part of the embryo is set aside to become the germ cell lineage that will ultimately differentiate to form sperm and eggs and transmit…”
Get full text

Nutrient regulation by continuous feeding removes limitations on cell yield in the large-scale expansion of Mammalian cell spheroids by Weegman, Bradley P, Nash, Peter, Carlson, Alexandra L, Voltzke, Kristin J, Geng, Zhaohui, Jahani, Marjan, Becker, Benjamin B, Papas, Klearchos K, Firpo, Meri T

“…Cellular therapies are emerging as a standard approach for the treatment of several diseases. However, realizing the promise of cellular therapies across the…”
Get full text

Manipulation of OCT4 levels in human embryonic stem cells results in induction of differential cell types by Rodriguez, Ryan T, Velkey, J Matthew, Lutzko, Carolyn, Seerke, Rina, Kohn, Donald B, O'Shea, K Sue, Firpo, Meri T

“…To fully understand self-renewal and pluripotency and their regulation in human embryonic stem cells (hESCs), it is necessary to generate genetically modified…”
Get more information

Derivation of Human Embryonic Stem Cells by Crook, Jeremy M, Kravets, Lucy, Peura, Teija, Firpo, Meri T

“…Embryonic stem cells (ESCs) represent a mainstay for pluripotent stem cell research and development (R&D) and provide tangible opportunities for clinical…”
Get more information

Spontaneous differentiation of germ cells from human embryonic stem cells in vitro by Clark, Amander T., Bodnar, Megan S., Fox, Mark, Rodriquez, Ryan T., Abeyta, Michael J., Firpo, Meri T., Pera, Renee A. Reijo

“…Little is known of molecular requirements for specification of human germ cells. However, it is likely that they are specified through the action of…”
Get full text

Potentially immunogenic proteins expressed similarly in human embryonic stem cells and induced pluripotent stem cells by Maynard, Kristen M, Arvindam, Upasana, Cross, Madeline, Firpo, Meri T

“…A major limitation of the use of cellular therapies is the loss of donor-derived cells because of immune incompatibility. While induced pluripotent stem (iPS)…”
Get more information

Development and Validation of Noninvasive Magnetic Resonance Relaxometry for the In Vivo Assessment of Tissue-Engineered Graft Oxygenation by Einstein, Samuel A, Weegman, Bradley P, Firpo, Meri T, Papas, Klearchos K, Garwood, Michael

“…Techniques to monitor the oxygen partial pressure (pO ) within implanted tissue-engineered grafts (TEGs) are critically necessary for TEG development, but…”
Get more information

Unique gene expression signatures of independently-derived human embryonic stem cell lines by Abeyta, Michael J., Clark, Amander T., Rodriguez, Ryan T., Bodnar, Megan S., Pera, Renee A. Reijo, Firpo, Meri T.

“…Human embryonic stem cells (hESCs) have the potential to differentiate to diverse cell types. This ability endows hESCs with promise for the development of…”
Get full text

Human STELLAR, NANOG, and GDF3 Genes Are Expressed in Pluripotent Cells and Map to Chromosome 12p13, a Hotspot for Teratocarcinoma by Clark, Amander T., Rodriguez, Ryan T., Bodnar, Megan S., Abeyta, Michael J., Cedars, Marcelle I., Turek, Paul J., Firpo, Meri T., Reijo Pera, Renee A.

“…Genes required to maintain pluripotency in human embryonic stem (hES) cells are largely unknown, with the exception of OCT‐4, a homolog of mouse Oct‐4, which…”
Get full text

Development of serum-free culture systems for human embryonic stem cells by Chase, Lucas G, Firpo, Meri T

“…Human embryonic stem cells, because of their unique combination of long-term self-renewal properties and pluripotency, are providing new avenues of…”
Get full text

Nutrient Regulation by Continuous Feeding for Large-scale Expansion of Mammalian Cells in Spheroids by Weegman, Bradley P, Essawy, Ahmad, Nash, Peter, Carlson, Alexandra L, Voltzke, Kristin J, Geng, Zhaohui, Jahani, Marjan, Becker, Benjamin B, Papas, Klearchos K, Firpo, Meri T

“…In this demonstration, spheroids formed from the β-TC6 insulinoma cell line were cultured as a model of manufacturing a mammalian islet cell product to…”
Get full text

The Hox cofactor and proto-oncogene Pbx1 is required for maintenance of definitive hematopoiesis in the fetal liver by DiMartino, Jorge F., Selleri, Licia, Traver, David, Firpo, Meri T., Rhee, Joon, Warnke, Roger, O'Gorman, Stephen, Weissman, Irving L., Cleary, Michael L.

“…Pbx1 is the product of a proto-oncogene originally discovered at the site of chromosomal translocations in acute leukemias. It binds DNA as a complex with a…”
Get full text

From cell culture to a cure: pancreatic β-cell replacement strategies for diabetes mellitus by Chhoun, Jennifer M, Voltzke, Kristin J, Firpo, Meri T

“…Numerous advances have been made in pancreatic β-cell replacement therapies for diabetes mellitus. While these therapies provide a positive impact and possible…”
Get more information

TGFβ inhibition of yolk-sac-like differentiation of human embryonic stem-cell-derived embryoid bodies illustrates differences between early mouse and human development by Poon, Ellen, Clermont, Frederic, Firpo, Meri T., Akhurst, Rosemary J.

“…Transforming growth factor β (TGFβ) plays an important role in development and maintenance of murine yolk sac vascular development. Targeted deletions of Tgfb1…”
Get full text