Search Results - "Firestone, Raymond A"

Cathepsin B-Labile Dipeptide Linkers for Lysosomal Release of Doxorubicin from Internalizing Immunoconjugates:  Model Studies of Enzymatic Drug Release and Antigen-Specific In Vitro Anticancer Activity by Dubowchik, Gene M, Firestone, Raymond A, Padilla, Linda, Willner, David, Hofstead, Sandra J, Mosure, Kathleen, Knipe, Jay O, Lasch, Shirley J, Trail, Pamela A

“…The anticancer drug doxorubicin (DOX) has been linked to chimeric BR96, an internalizing monoclonal antibody that binds to a Lewisy-related, tumor-associated…”
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The Low Energy of Concert in Many Symmetry-Allowed Cycloadditions Supports a Stepwise-Diradical Mechanism by Firestone, Raymond A.

“…ABSTRACT The thesis of this paper is that orbital symmetry allowedness does not guarantee concert. The activation energy (Ea) for concerted Diels–Alder and…”
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Low-Density Lipoprotein as a Vehicle for Targeting Antitumor Compounds to Cancer Cells by Firestone, Raymond A

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Lessons from 54 years of pharmaceutical research by Firestone, Raymond A.

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Synergistic Anticancer Action of Lysosomal Membrane Permeabilization and Glycolysis Inhibition by Kosic, Milica, Arsikin-Csordas, Katarina, Paunovic, Verica, Firestone, Raymond A., Ristic, Biljana, Mircic, Aleksandar, Petricevic, Sasa, Bosnjak, Mihajlo, Zogovic, Nevena, Mandic, Milos, Bumbasirevic, Vladimir, Trajkovic, Vladimir, Harhaji-Trajkovic, Ljubica

“…We investigated the in vitro and in vivo anticancer effect of combining lysosomal membrane permeabilization (LMP)-inducing agent N-dodecylimidazole (NDI) with…”
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Synthesis of an immunoconjugate of camptothecin by Walker, Michael A, Dubowchik, Gene M, Hofstead, Sandra J, Trail, Pamela A, Firestone, Raymond A

“…The first immunoconjugate of camptothecin has been synthesized wherein the drug is attached to the tumor-recognizing antibody BR96 via a Cathepsin B cleavable…”
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Cathepsin B Cleavable Novel Prodrug Ac-Phe-Lys-PABC-ADM Enhances Efficacy at Reduced Toxicity in Treating Gastric Cancer Peritoneal Carcinomatosis: An Experimental Study by SHAO, Li-Hua, LIU, Shao-Ping, YAN LI, HOU, Jin-Xuan, ZHANG, Yan-Hua, PENG, Chun-Wei, ZHONG, Yan-Jun, XIONG LIU, LIU, Xiu-Li, HONG, Ya-Ping, FIRESTONE, Raymond A

“…Doxorubicin (Adriamycin) is effective in gastric cancer treatment, but with severe dose-dependent toxicities. A novel prodrug of doxorubicin…”
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(6-Maleimidocaproyl)hydrazone of doxorubicin. A new derivative for the preparation of immunoconjugates of doxorubicin by Willner, David, Trail, Pamela A, Hofstead, Sandra J, King, H. Dalton, Lasch, Shirley J, Braslawsky, Gary R, Greenfield, Robert S, Kaneko, Takushi, Firestone, Raymond A

“…The (6-maleimidocaproyl)hydrazone of doxorubicin was synthesized and conjugated to several mAbs, including chimeric BR96, via a Michael addition reaction to…”
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Targeting therapy of hepatocellular carcinoma with doxorubicin prodrug PDOX increases anti-metastatic effect and reduces toxicity: a preclinical study by Wang, Qun, Zhong, Yan-Jun, Yuan, Jing-Ping, Shao, Li-Hua, Zhang, Jue, Tang, Li, Liu, Shao-Ping, Hong, Ya-Ping, Firestone, Raymond A, Li, Yan

“…This study was to investigate the effects and safety of cathepsin B-cleavable doxorubicin (DOX)-prodrug (PDOX) for targeting therapy of metastatic human…”
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Experimental evidence of good efficacy and reduced toxicity with peptide-doxorubicin to treat gastric cancer by Zhang, Jue, Yuan, Jing-Ping, Wang, Qun, Shao, Li-Hua, Liu, Shao-Ping, Firestone, Raymond A, Hong, Ya-Ping, Li, Ji-Guo, Xin, Yan-Chao, Li, Yan

“…To compare the efficacy and toxicity of peptide-doxorubicin (PDOX) and doxorubicin (DOX) on nude mice models of human gastric cancer. Both PDOX and DOX could…”
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Studies with vitamin E and β-carotene as single agents do not prove lack of benefit by Firestone, Raymond A.

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Lipid‐lowering agents may fight cancer by denying it LDL by Firestone, Raymond A.

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Anticancer effects of Ac-Phe-Lys-PABC-doxorubicin via mitochondria-centered apoptosis involving reactive oxidative stress and the ERK1/2 signaling pathway in MGC-803 cells by ZHONG, YAN-JUN, LIU, SHAO-PING, FIRESTONE, RAYMOND A, HONG, YA-PING, LI, YAN

“…Ac-Phe-Lys-PABC-DOX (PDOX) is a smart doxorubicin (DOX) prodrug designed to decrease toxicities while maintaining the potent anticancer effects of DOX. The…”
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Synthesis, identification and in vivo studies of tumor-targeting agent peptide doxorubicin (PDOX) to treat peritoneal carcinomatosis of gastric cancer with similar efficacy but reduced toxicity by Tang, Li, Duan, Rui, Zhong, Yan-jun, Firestone, Raymond A, Hong, Ya-ping, Li, Ji-guo, Xin, Yan-chao, Wu, Han-lin, Li, Yan

“…This work aimed to synthesize a cathepsin B (CTSB)-cleavable tumor-targeting prodrug peptide doxorubicin (PDOX) and study the in vivo efficacy and toxicities…”
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Induction of cell death by the lysosomotropic detergent MSDH by Li, Wei, Yuan, XiMing, Nordgren, Gunnar, Dalen, Helge, Dubowchik, Gene M., Firestone, Raymond A., Brunk, Ulf T.

“…Controlled lysosomal rupture was initiated in lysosome-rich, macrophage-like cells by the synthetic lysosomotropic detergent, O-methyl-serine dodecylamide…”
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Monoclonal Antibody Conjugates of Doxorubicin Prepared with Branched Peptide Linkers:  Inhibition of Aggregation by Methoxytriethyleneglycol Chains by King, H. Dalton, Dubowchik, Gene M, Mastalerz, Harold, Willner, David, Hofstead, Sandra J, Firestone, Raymond A, Lasch, Shirley J, Trail, Pamela A

“…High mole ratio BR96 immunoconjugates were synthesized using branched peptide−doxorubicin linkers designed to liberate doxorubicin following antigen-specific…”
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Drug giants hamstrung by timid middle management by Firestone, Raymond A

“…A letter to the editor regarding hierarchical organizational structures in pharmaceutical companies is presented…”
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Cathepsin B-sensitive dipeptide prodrugs. 1. A model study of structural requirements for efficient release of doxorubicin by Dubowchik, Gene M., Firestone, Raymond A.

“…A series of lysosomal protease-sensitive peptides attached to doxorubicin (DOX) was prepared as model substrates for internalizing anticancer immunoconjugates…”
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Anti-Cancer Effects of Novel Doxorubicin Prodrug PDOX in MCF-7 Breast Cancer Cells by 张珏 何良 耿霞飞 Raymond A. Firestone 洪亚平 李雁

“…Ac-Phe-Lys-PABC-DOX（PDOX） is a smart doxorubicin（DOX） prodrug designed to decrease toxicities while maintaining the potent anticancer effects of DOX. This…”
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Reply to “Comment on ‘Phantom Activation Volumes'” by Firestone, Raymond A, Swiss, Kevin A

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