Search Results - "Firestone, R. A."

Cure of Xenografted Human Carcinomas by BR96-Doxorubicin Immunoconjugates by Trail, P. A., Willner, D., Lasch, S. J., Henderson, A. J., Hofstead, S., Casazza, A. M., Firestone, R. A., Hellström, I., Hellström, K. E.

“…Immunoconjugates (BR96-DOX) were prepared between chimeric monoclonal antibody BR96 and the anticancer drug doxorubicin. The monoclonal antibody binds an…”
Get full text

Comparison of micro-CT and cone beam CT-based assessments for relative difference of grey level distribution in a human mandible by Taylor, T T, Gans, S I, Jones, E M, Firestone, A R, Johnston, W M, Kim, D-G

“…The purpose of this study was to examine the ability of CT to assess the relative difference of degree of bone mineralization (grey level) parameters in a…”
Get full text

Cathepsin B-sensitive dipeptide prodrugs. 1. A model study of structural requirements for efficient release of doxorubicin by Dubowchik, Gene M., Firestone, Raymond A.

“…A series of lysosomal protease-sensitive peptides attached to doxorubicin (DOX) was prepared as model substrates for internalizing anticancer immunoconjugates…”
Get full text

Perception of pain as a result of orthodontic treatment with fixed appliances by Scheurer, Philipp A., Firestone, Allen R., Bürgin, Walter B.

“…The aims of this study were to investigate the intensity, location and duration of patients' discomfort following insertion of orthodontic appliances, and to…”
Get full text

Cathepsin B-sensitive dipeptide prodrugs. 2. Models of anticancer drugs paclitaxel (Taxol®), mitomycin C and doxorubicin by Dubowchik, Gene M., Mosure, Kathleen, Knipe, Jay O., Firestone, Raymond A.

“…Substrates containing doxorubicin (DOX), paclitaxel (taxol®), and mitomycin C (MMC) attached to the cathepsin B-sensitive dipeptide Phe-Lys via a…”
Get full text

(6-Maleimidocaproyl)hydrazone of doxorubicin. A new derivative for the preparation of immunoconjugates of doxorubicin by Willner, David, Trail, Pamela A, Hofstead, Sandra J, King, H. Dalton, Lasch, Shirley J, Braslawsky, Gary R, Greenfield, Robert S, Kaneko, Takushi, Firestone, Raymond A

“…The (6-maleimidocaproyl)hydrazone of doxorubicin was synthesized and conjugated to several mAbs, including chimeric BR96, via a Michael addition reaction to…”
Get full text

Cell Killing by Lysosomotropic Detergents by Miller, Douglas K., Griffiths, Elizabeth, Lenard, John, Firestone, Raymond A.

“…We have studied the mechanism by which lysosomotropic detergents kill baby hamster kidney cells. Lysosomotropic detergents are lysosomotropic amines (compounds…”
Get full text

The effect of a knowledge-based, image analysis and clinical decision support system on observer performance in the diagnosis of approximal caries from radiographic images by Firestone, A R, Sema, D, Heaven, T J, Weems, R A

“…The aim of this study was to investigate the effect of a knowledge-based image analysis and clinical decision support system (CariesFinder, CF) on diagnostic…”
Get more information

Effect of linker variation on the stability, potency, and efficacy of carcinoma-reactive BR64-doxorubicin immunoconjugates by TRAIL, P. A, WILLNER, D, BRASLAWSKY, G. R, BROWN, J, HOFSTEAD, S. J, GREENFIELD, R. S, FIRESTONE, R. A, MOSURE, K, KADOW, K. F, YANG, M. B, HELLSTRÖM, K. E, HELLSTRÖM, I, KNIPE, J, HENDERSON, A. J, LASCH, S. J, ZOECKLER, M. E, TRAILSMITH, M. D, DOYLE, T. W, KING, H. D, CASAZZA, A. M

“…The internalizing anti-Le(y) monoclonal antibody (MAb) BR64 was conjugated to the anticancer drug doxorubicin (DOX) using an acid-labile hydrazone bond to the…”
Get full text

Induction of cell death by the lysosomotropic detergent MSDH by Li, Wei, Yuan, XiMing, Nordgren, Gunnar, Dalen, Helge, Dubowchik, Gene M., Firestone, Raymond A., Brunk, Ulf T.

“…Controlled lysosomal rupture was initiated in lysosome-rich, macrophage-like cells by the synthetic lysosomotropic detergent, O-methyl-serine dodecylamide…”
Get full text

The Role of Lysosomal Enzymes in Killing of Mammalian Cells by the Lysosomotropic Detergent N-Dodecylimidazole by Wilson, Patricia D., Firestone, Raymond A., Lenard, John

“…The sensitivity of cultured human and hamster fibroblast cells to killing by the lysosomotropic detergent N-dodecylimidazole ( C12- Im) was investigated as a…”
Get full text

Inhibition of antibacterial activity of himastatin, a new antitumor antibiotic from Streptomyces hygroscopicus, by fatty acid sodium salts by MAMBER, S. W, BROOKSHIRE, K. W, DEAN, B. J, FIRESTONE, R. A, LEET, J. E, MATSON, J. A, FORENZA, S

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

pH dependent cytotoxicity of N-dodecylimidazole: a compound that acquires detergent properties under acidic conditions by BOYER, M. J, HORN, I, FIRESTONE, R. A, STEELE-NORWOOD, D, TANNOCK, I. F

“…N-dodecylimidazole is a compound which acquires detergent properties under acidic conditions and might be useful in killing selectively cells in those regions…”
Get full text

Low-Density Lipoprotein as a Vehicle for Targeting Antitumor Compounds to Cancer Cells by Firestone, Raymond A

Get full text

Synthesis and antitumor activity of the immunoconjugate BR96-Dox by Firestone, R.A., Willner, D., Hofstead, S.J., King, H.D., Kaneko, T., Braslawsky, G.R., Greenfield, R.S., Trail, P.A., Lasch, S.J., Henderson, A.J., Casazza, A.M., Hellström, I., Hellström, K.E.

“…BR96-Dox is an immunoconjugate (IC) in which doxorubicin (8 equivalents) is linked via an acid-labile hydrazone to the chimeric MAb BR96. It binds to a…”
Get full text

Cephalosporin antibiotics can be modified to inhibit human leukocyte elastase by Doherty, James B, Ashe, Bonnie M, Argenbright, Lawrence W, Barker, Peter L, Bonney, Robert J, Chandler, Gilbert O, Dahlgren, Mary Ellen, Dorn, Conrad P, Finke, Paul E, Firestone, Raymond A, Fletcher, Daniel, Hagmann, William K, Mumford, Richard, O'Grady, Laura, Maycock, Alan L, Pisano, Judith M, Shah, Shrenik K, Thompson, Kevan R, Zimmerman, Morris

“…Several laboratories, including our own have reported the synthesis and activity of certain low relative molecular mass inhibitors of mammalian serine…”
Get full text

Radiographic evaluation of occlusal caries: effect of training and experience by Lazarchik, D A, Firestone, A R, Heaven, T J, Filler, S J, Lussi, A

“…The purpose of this study was to investigate what effect differing levels of didactic education and clinical experience have on the ability to diagnose…”
Get more information

Using computers to diagnose and plan treatment of approximal caries. Detected in radiographs by Duncan, R C, Heaven, T, Weems, R A, Firestone, A R, Greer, D F, Patel, J R

“…Two of the authors developed a computer-based software system that is capable of diagnosing approximal caries and making decisions about restorative care. The…”
Get more information

A comparison of the reliability and validity of 3 occlusal indexes of orthodontic treatment need by Beglin, Frank M., Firestone, Allen R., Vig, Katherine W.L., Beck, F.Michael, Kuthy, Raymond A., Wade, Dale

“…Several occlusal indexes are currently used to ascertain eligibility for orthodontic treatment. A comparison of 3 indexes of orthodontic treatment need was…”
Get full text

Patients' anticipation of pain and pain-related side effects, and their perception of pain as a result of orthodontic treatment with fixed appliances by Firestone, AR, Scheurer, PA, Bürgin, WB

“…The aim of this study was to investigate the relationship between (i) the pain and its side effects, anticipated by patients before orthodontic therapy, and…”
Get full text