Search Results - "Firestine, Steven"

Isatins Inhibit N5‑CAIR Synthetase by a Substrate Depletion Mechanism by Streeter, Cale C, Lin, Qian, Firestine, Steven M

“…The continued rise of antibiotic-resistant infections coupled with the limited pipeline of new antimicrobials highlights the pressing need for the development…”
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Antibiotic-loaded nanoparticles for the treatment of intracellular methicillin-resistant Staphylococcus Aureus infections: In vitro and in vivo efficacy of a novel antibiotic by Costabile, Gabriella, Baldassi, Domizia, Müller, Christoph, Groß, Birgit, Ungaro, Francesca, Schubert, Sören, Firestine, Steven M., Merkel, Olivia M.

“…Antimicrobial resistance is considered one of the biggest threats to public health worldwide. Methicillin-resistant S. aureus is the causative agent of a…”
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A Fluorescence‐Based Assay for N5‐Carboxyaminoimidazole Ribonucleotide Mutase by Sharma, Marcella F, Sharma, Shiv K, Streeter, Cale C, Firestine, Steven M

“…The enzyme N5‐carboxylaminoinidazole ribonucleotide (N5‐CAIR) mutase is found in microbial de novo purine biosynthesis but is absent in humans making it an…”
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A Fluorescence-Based Assay for N 5 -Carboxyaminoimidazole Ribonucleotide Mutase by Sharma, Marcella F, Sharma, Shiv K, Streeter, Cale C, Firestine, Steven M

“…The enzyme N -carboxylaminoinidazole ribonucleotide (N -CAIR) mutase is found in microbial de novo purine biosynthesis but is absent in humans making it an…”
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Isatins Inhibit N 5 -CAIR Synthetase by a Substrate Depletion Mechanism by Streeter, Cale C, Lin, Qian, Firestine, Steven M

“…The continued rise of antibiotic-resistant infections coupled with the limited pipeline of new antimicrobials highlights the pressing need for the development…”
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Studies on the Importance of the 7α-, and 12α- hydroxyl groups of N-Aryl-3α,7α,12α-trihydroxy-5β-cholan-24-amides on their Antigermination Activity Against a Hypervirulent Strain of Clostridioides (Clostridium) difficile by Sharma, Shiv K., Yip, Christopher, Simon, Matthew P., Phan, Jacqueline, Abel-Santos, Ernesto, Firestine, Steven M.

“…[Display omitted] Chenodeoxycholic acid (CDCA) is a natural germination inhibitor for C. difficile spores. In our previous study (J. Med. Chem., 2018, 61,…”
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The design, synthesis, and inhibition of Clostridioides difficile spore germination by acyclic and bicyclic tertiary amide analogs of cholate by Sharma, Shiv K., Schilke, Angel R., Phan, Jacqueline R., Yip, Christopher, Sharma, Prateek V., Abel-Santos, Ernesto, Firestine, Steven M.

“…Clostridioides difficile infection (CDI) is a major identifiable cause of antibiotic-associated diarrhea. In our previous study (J. Med. Chem., 2018, 61,…”
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The ATP-grasp enzymes by Fawaz, Maria V., Topper, Melissa E., Firestine, Steven M.

“…[Display omitted] ► ATP-grasp enzymes utilize an unique ATP-binding fold. ► These enzymes are found in critical metabolic pathways and are medicinally…”
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An Aniline-Substituted Bile Salt Analog Protects both Mice and Hamsters from Multiple Clostridioides difficile Strains by Phan, Jacqueline R, Do, Dung M, Truong, Minh Chau, Ngo, Connie, Phan, Julian H, Sharma, Shiv K, Schilke, Angel, Mefferd, Chrisabelle C, Villarama, Jacob V, Lai, Dengxun, Consul, Amber, Hedlund, Brian P, Firestine, Steven M, Abel-Santos, Ernesto

“…Clostridioides difficile infection (CDI) is the major identifiable cause of antibiotic-associated diarrhea. The emergence of hypervirulent C. difficile strains…”
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The Design, Synthesis, and Characterizations of Spore Germination Inhibitors Effective against an Epidemic Strain of Clostridium difficile by Sharma, Shiv K, Yip, Christopher, Esposito, Emilio Xavier, Sharma, Prateek V, Simon, Matthew P, Abel-Santos, Ernesto, Firestine, Steven M

“…Clostridium difficile infections (CDI), particularly those caused by the BI/NAP1/027 epidemic strains, are challenging to treat. One method to address this…”
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Design, Synthesis, and Structure−Activity Relationships of Benzophenone-Based Tetraamides as Novel Antibacterial Agents by Vooturi, Sunil K, Cheung, Chrissy M, Rybak, Michael J, Firestine, Steven M

“…The increase in the incidence of both hospital- and community-acquired antibiotic-resistant infections is a major concern to the healthcare community. There…”
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PAICS ubiquitination recruits UBAP2 to trigger phase separation for purinosome assembly by Chou, Ming-Chieh, Wang, Yi-Hsuan, Chen, Fei-Yun, Kung, Chun-Ying, Wu, Kuen-Phon, Kuo, Jean-Cheng, Chan, Shu-Jou, Cheng, Mei-Ling, Lin, Chih-Yu, Chou, Yu-Chi, Ho, Meng-Chiao, Firestine, Steven, Huang, Jie-rong, Chen, Ruey-Hwa

“…Purinosomes serve as metabolons to enhance de novo purine synthesis (DNPS) efficiency through compartmentalizing DNPS enzymes during stressed conditions…”
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Thieno[2,3-d]pyrimidinedione derivatives as antibacterial agents by Dewal, Mahender B., Wani, Amit S., Vidaillac, Celine, Oupický, David, Rybak, Michael J., Firestine, Steven M.

“…Several thieno[2,3-d]pyrimidinediones have been synthesized and examined for antibacterial activity against a range of Gram-positive and Gram-negative…”
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Site-directed mutagenesis of catalytic residues in N(5)-carboxyaminoimidazole ribonucleotide synthetase by Dewal, Mahender B, Firestine, Steven M

“…N(5)-CAIR synthetase, an essential enzyme in microorganisms, converts 5-aminoimidazole ribonucleotide (AIR) and bicarbonate to N(5)-CAIR with the aid of ATP…”
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Site-Directed Mutagenesis of Catalytic Residues in N 5‑Carboxyaminoimidazole Ribonucleotide Synthetase by Dewal, Mahender B, Firestine, Steven M

“…N 5-CAIR synthetase, an essential enzyme in microorganisms, converts 5-aminoimidazole ribonucleotide (AIR) and bicarbonate to N 5-CAIR with the aid of ATP…”
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Cyclam-Based Polymeric Copper Chelators for Gene Delivery and Potential PET Imaging by Li, Jing, Zhu, Yu, Hazeldine, Stuart T, Firestine, Steven M, Oupický, David

“…A series of reducible polycationic copper chelators (RPCs) based on 1,4,8,11-tetraazacyclotetradecane (cyclam) were synthesized by Michael addition. Molecular…”
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Intramolecular Charge-Assisted Hydrogen Bond Strength in Pseudochair Carboxyphosphate by Kochanek, Sarah E, Clymer, Traci M, Pakkala, Venkata S, Hebert, Sebastien P, Reeping, Kyle, Firestine, Steven M, Evanseck, Jeffrey D

“…Carboxyphosphate, a suspected intermediate in ATP-dependent carboxylases, has not been isolated nor observed directly by experiment. Consequently, little is…”
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Physicochemical and In Vitro Evaluation of Drug Delivery of an Antibacterial Synthetic Benzophenone in Biodegradable PLGA Nanoparticles by Costabile, Gabriella, Gasteyer, Kathrin I., Nadithe, Venkatereddy, Van Denburgh, Katherine, Lin, Qian, Sharma, Shiv, Reineke, Joshua J., Firestine, Steven M., Merkel, Olivia M.

“…Due to the increasing incidents of antimicrobial-resistant pathogens, the development of new antibiotics and their efficient formulation for suitable…”
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Benzo(h)quinoline derivatives as G-quadruplex binding agents by PARITALA, Hanumantharao, FIRESTINE, Steven M

“…G-quadruplexes are unusual structures formed from guanine-rich sequences of nucleic acids. G-quadruplexes have been postulated to play important roles in a…”
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Examination of a synthetic benzophenone membrane-targeted antibiotic by Vooturi, Sunil K, Dewal, Mahender B, Firestine, Steven M

“…The enormous success of antibiotics is seriously threatened by the development of resistance to most of the drugs available on the market. Thus, novel…”
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