Search Results - "Firestein, GS"

TLR2 Signaling in Chondrocytes Drives Calcium Pyrophosphate Dihydrate and Monosodium Urate Crystal-Induced Nitric Oxide Generation by Liu-Bryan, Ru, Pritzker, Kenneth, Firestein, Gary S, Terkeltaub, Robert

“…Microcrystals of calcium pyrophosphate dihydrate (CPPD) and monosodium urate (MSU) deposited in synovium and articular cartilage initiate joint inflammation…”
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Regulation of synoviocyte proliferation, apoptosis, and invasion by the p53 tumor suppressor gene by Aupperle, KR, Boyle, DL, Hendrix, M, Seftor, EA, Zvaifler, NJ, Barbosa, M, Firestein, GS

“…Recent studies show that 1) the p53 tumor suppressor protein is overexpressed by rheumatoid arthritis (RA) synovium and fibroblast-like synoviocytes (FLS) and…”
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Quantitative analysis of cytokine gene expression in rheumatoid arthritis [published erratum appears in J Immunol 1990 Aug 1;145(3):1037] by Firestein, GS, Alvaro-Gracia, JM, Maki, R, Alvaro-Garcia JM$[corrected to Alvaro-Gracia, JM]

“…Previous studies of the cytokine profile of rheumatoid arthritis (RA) have been primarily limited to the assessment of the levels of these mediators in…”
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Anticytokine Therapy in Rheumatoid Arthritis by Firestein, Gary S, Zvaifler, Nathan J

“…Only a few years ago, little was known about the role of cytokines in rheumatoid arthritis. The original view of the cytokine milieu in the inflamed joint as a…”
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Evolving concepts of rheumatoid arthritis by Firestein, Gary S

“…Rheumatoid arthritis is the most common inflammatory arthritis and is a major cause of disability. It existed in early Native American populations several…”
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Anti-inflammatory effects of ABT-702, a novel non-nucleoside adenosine kinase inhibitor, in rat adjuvant arthritis by Boyle, D L, Kowaluk, E A, Jarvis, M F, Lee, C H, Bhagwat, S S, Williams, M, Firestein, G S

“…Adenosine (ADO) is a homeostatic inhibitory autocoid that is released at sites of inflammation and tissue injury, and exerts anti-inflammatory effects via…”
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NF-κB: a key role in inflammatory diseases by Tak, Paul P., Firestein, Gary S.

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The T cell cometh: interplay between adaptive immunity and cytokine networks in rheumatoid arthritis by Firestein, Gary S.

“…The etiology of autoimmunity in humans remains poorly defined, and animal models provide a unique opportunity to study potential autoimmune mechanisms. A novel…”
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IL-1 receptor antagonist protein production and gene expression in rheumatoid arthritis and osteoarthritis synovium by Firestein, GS, Berger, AE, Tracey, DE, Chosay, JG, Chapman, DL, Paine, MM, Yu, C, Zvaifler, NJ

“…IL-1 can participate in the perpetuation of arthritis through direct stimulation of synoviocytes and augmentation of matrix degradation. Hence, local…”
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Characterization of the acute and persistent pain state present in K/BxN serum transfer arthritis by Christianson, Christina A., Corr, Maripat, Firestein, Gary S., Mobargha, Anahita, Yaksh, Tony L., Svensson, Camilla I.

“…Rheumatoid arthritis (RA) is a chronic autoimmune arthritis that affects approximately 1% of the population. Synovial inflammation cannot fully explain the…”
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HIF-1α Is Essential for Myeloid Cell-Mediated Inflammation by Cramer, Thorsten, Yamanishi, Yuji, Clausen, Björn E., Förster, Irmgard, Pawlinski, Rafal, Mackman, Nigel, Haase, Volker H., Jaenisch, Rudolf, Corr, Maripat, Nizet, Victor, Firestein, Gary S., Gerber, Hans-Peter, Ferrara, Napoleone, Johnson, Randall S.

“…Granulocytes and monocytes/macrophages of the myeloid lineage are the chief cellular agents of innate immunity. Here, we have examined the inflammatory…”
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Rheumatoid arthritis: regulation of synovial inflammation by Sweeney, Susan E, Firestein, Gary S

“…Rheumatoid arthritis (RA) is a systemic, inflammatory autoimmune disorder that presents as a symmetric polyarthritis associated with swelling and pain in…”
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Immunologic Mechanisms in the Pathogenesis of Rheumatoid Arthritis by Firestein, Gary S

“…Although much is known about the etiology and pathogenesis of rheumatoid arthritis (RA), our understanding of the immune pathways remains incomplete. The…”
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A 24-Week, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study of the Efficacy of Oral SCIO-469, a p38 Mitogen-activated Protein Kinase Inhibitor, in Patients with Active Rheumatoid Arthritis by GENOVESE, Mark C, COHEN, Stanley B, WOFSY, David, WEINBLATT, Michael E, FIRESTEIN, Gary S, BRAHN, Ernest, STRAND, Vibeke, BAKER, Daniel G, TONG, Sandra E

“…To evaluate the efficacy, safety, and tolerability of oral SCIO-469, a p38 MAPK inhibitor that blocks tumor necrosis factor-α, interleukin-1ß, and…”
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Prevention of cold-associated acute inflammation in familial cold autoinflammatory syndrome by interleukin-1 receptor antagonist by Hoffman, Hal M, Rosengren, Sanna, Boyle, David L, Cho, Jae Y, Nayar, Jyothi, Mueller, James L, Anderson, Justin P, Wanderer, Alan A, Firestein, Gary S

“…Familial cold autoinflammatory syndrome (FCAS) is an autosomal dominant disorder characterised by recurrent episodes of rash, arthralgia, and fever after cold…”
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c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis by Han, Z, Boyle, D L, Chang, L, Bennett, B, Karin, M, Yang, L, Manning, A M, Firestein, G S

“…Mitogen-activated protein kinase (MAPK) cascades are involved in inflammation and tissue destruction in rheumatoid arthritis (RA). In particular, c-Jun…”
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A novel spleen tyrosine kinase inhibitor blocks c-Jun N-terminal kinase-mediated gene expression in synoviocytes by Cha, Hoon-Suk, Boyle, David L, Inoue, Tomoyuki, Schoot, Reineke, Tak, Paul P, Pine, Polly, Firestein, Gary S

“…Spleen tyrosine kinase (Syk) is a key regulator of cell signaling induced by cytokines or Fc receptor engagement. However, the role of Syk in rheumatoid…”
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Inhibiting Inflammation in Rheumatoid Arthritis by Firestein, Gary S

“…A kinase inhibitor protected against synovial inflammation and joint destruction in a mouse model of rheumatoid arthritis. A kinase inhibitor protected against…”
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Signal transduction networks in rheumatoid arthritis by Hammaker, D, Sweeney, S, Firestein, G S

“…Signal transduction pathways regulate cellular responses to stress and play a critical role in inflammation. The complexity and specificity of signalling…”
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Signal transduction in rheumatoid arthritis by Sweeney, Susan E, Firestein, Gary S

“…PURPOSESignal transduction pathways are the intracellular mechanism by which cells respond and adapt to environmental stress. Understanding the critical…”
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