Search Results - "Firestein, G S"

Choline kinase inhibition in rheumatoid arthritis by Guma, M, Sanchez-Lopez, E, Lodi, A, Garcia-Carbonell, R, Tiziani, S, Karin, M, Lacal, J C, Firestein, G S

“…Little is known about targeting the metabolome in non-cancer conditions. Choline kinase (ChoKα), an essential enzyme for phosphatidylcholine biosynthesis, is…”
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Assessment of rituximab's immunomodulatory synovial effects (ARISE trial). 1: clinical and synovial biomarker results by Kavanaugh, A, Rosengren, S, Lee, S J, Hammaker, D, Firestein, G S, Kalunian, K, Wei, N, Boyle, D L

“…Treatment with the anti-CD20 monoclonal antibody (mAb) rituximab is effective in rheumatoid arthritis (RA). Marked depletion of circulating B cells, seen in…”
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Mode of action of abatacept in rheumatoid arthritis patients having failed tumour necrosis factor blockade: a histological, gene expression and dynamic magnetic resonance imaging pilot study by Buch, M H, Boyle, D L, Rosengren, S, Saleem, B, Reece, R J, Rhodes, L A, Radjenovic, A, English, A, Tang, H, Vratsanos, G, O'Connor, P, Firestein, G S, Emery, P

“…Abatacept is the only agent currently approved to treat rheumatoid arthritis (RA) that targets the co-stimulatory signal required for full T-cell activation…”
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Mitogen activated protein kinase inhibitors: where are we now and where are we going? by Sweeney, S E, Firestein, G S

“…Orally bioavailable compounds that target key intracellular signalling molecules are receiving increasing attention for the treatment of rheumatic diseases…”
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"Go upstream, young man": lessons learned from the p38 saga by Hammaker, D, Firestein, G S

“…Despite the success of biological therapies in rheumatoid arthritis (RA), orally active small-molecule drugs are desirable. Signal transduction inhibitors have…”
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c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis by Han, Z, Boyle, D L, Chang, L, Bennett, B, Karin, M, Yang, L, Manning, A M, Firestein, G S

“…Mitogen-activated protein kinase (MAPK) cascades are involved in inflammation and tissue destruction in rheumatoid arthritis (RA). In particular, c-Jun…”
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Validated gene expression biomarker analysis for biopsy‐based clinical trials in ulcerative colitis by Boland, B. S., Boyle, D. L., Sandborn, W. J., Firestein, G. S., Levesque, B. G., Hillman, J., Zhang, B., Proudfoot, J., Eckmann, L., Ernst, P. B., Rivera‐Nieves, J., Pola, S., Copur‐Dahi, N., Chang, J. T.

“…Summary Background Accurate and reproducible measurement of expression of pro‐inflammatory cytokines in colonic biopsies from patients with ulcerative colitis…”
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Signal transduction networks in rheumatoid arthritis by Hammaker, D, Sweeney, S, Firestein, G S

“…Signal transduction pathways regulate cellular responses to stress and play a critical role in inflammation. The complexity and specificity of signalling…”
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Enhanced gene transfer to arthritic joints using adeno-associated virus type 5: implications for intra-articular gene therapy by Adriaansen, J, Tas, S W, Klarenbeek, P L, Bakker, A C, Apparailly, F, Firestein, G S, Jorgensen, C, Vervoordeldonk, M J B M, Tak, P P

“…Background: Gene therapy of the joint has great potential as a new therapeutic approach for the treatment of rheumatoid arthritis (RA). The vector chosen is of…”
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The JAK inhibitor tofacitinib suppresses synovial JAK1-STAT signalling in rheumatoid arthritis by Boyle, D L, Soma, K, Hodge, J, Kavanaugh, A, Mandel, D, Mease, P, Shurmur, R, Singhal, A K, Wei, N, Rosengren, S, Kaplan, I, Krishnaswami, S, Luo, Z, Bradley, J, Firestein, G S

“…Tofacitinib is an oral Janus kinase (JAK) inhibitor for the treatment of rheumatoid arthritis (RA). The pathways affected by tofacitinib and the effects on…”
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Starving the synovium: angiogenesis and inflammation in rheumatoid arthritis by Firestein, G S

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MKK3, an upstream activator of p38, contributes to formalin phase 2 and late allodynia in mice by Sorkin, L.S, Boyle, D.L, Hammaker, D, Herman, D.S, Vail, E, Firestein, G.S

“…Abstract Spinal p38 mitogen activated (MAP) kinase plays a key role in chronic pain behavior. However, clinical development of p38 inhibitors has been hindered…”
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Acid-sensing ion channel 3 expressed in type B synoviocytes and chondrocytes modulates hyaluronan expression and release by Kolker, S J, Walder, R Y, Usachev, Y, Hillman, J, Boyle, D L, Firestein, G S, Sluka, K A

“…Rheumatoid arthritis is an inflammatory disease marked by intra-articular decreases in pH, aberrant hyaluronan regulation and destruction of bone and…”
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Evolving concepts of rheumatoid arthritis by Firestein, Gary S

“…Rheumatoid arthritis is the most common inflammatory arthritis and is a major cause of disability. It existed in early Native American populations several…”
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Apoptosis in rheumatoid arthritis: p53 overexpression in rheumatoid arthritis synovium by Firestein, GS, Nguyen, K, Aupperle, KR, Yeo, M, Boyle, DL, Zvaifler, NJ

“…DNA damage induces p53 tumor suppressor gene expression and protein production, which in turn facilitates DNA repair or apoptosis. Wild-type p53 protein has a…”
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Regulation of synoviocyte proliferation, apoptosis, and invasion by the p53 tumor suppressor gene by Aupperle, KR, Boyle, DL, Hendrix, M, Seftor, EA, Zvaifler, NJ, Barbosa, M, Firestein, GS

“…Recent studies show that 1) the p53 tumor suppressor protein is overexpressed by rheumatoid arthritis (RA) synovium and fibroblast-like synoviocytes (FLS) and…”
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Quantitative analysis of cytokine gene expression in rheumatoid arthritis [published erratum appears in J Immunol 1990 Aug 1;145(3):1037] by Firestein, GS, Alvaro-Gracia, JM, Maki, R, Alvaro-Garcia JM$[corrected to Alvaro-Gracia, JM]

“…Previous studies of the cytokine profile of rheumatoid arthritis (RA) have been primarily limited to the assessment of the levels of these mediators in…”
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Eosinophils express interleukin 5 and granulocyte macrophage-colony-stimulating factor mRNA at sites of allergic inflammation in asthmatics by BROIDE, D. H, PAINE, M. M, FIRESTEIN, G. S

“…IL-5 and granulocyte macrophage-colony-stimulating factor (GM-CSF) are important regulators of eosinophil survival, proliferation, and effector function. To…”
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Intra-articular IL-4 gene therapy in arthritis : anti-inflammatory effect and enhanced Th2 activity by BOYLE, D. L, NGUYEN, K. H. Y, ZHUANG, S, SHI, Y, MCCORMACK, J. E, CHADA, S, FIRESTEIN, G. S

“…Gene therapy has been explored as a potential method for treating chronic inflammatory diseases such as rheumatoid arthritis. To determine the efficacy of…”
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p53 in rheumatoid arthritis synovial fibroblasts at sites of invasion by Seemayer, C A, Kuchen, S, Neidhart, M, Kuenzler, P, Řihošková, V, Neumann, E, Pruschy, M, Aicher, W K, Müller-Ladner, U, Gay, R E, Michel, B A, Firestein, G S, Gay, S

“…Objective: To analyse the functional response of p53 in rheumatoid arthritis synovial fibroblasts (RASF) in vitro and in vivo and to investigate whether…”
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