Search Results - "Fire, A"

RNA-triggered gene silencing by Fire, Andrew

“…Double-stranded RNA (dsRNA) has recently been shown to trigger sequence-specific gene silencing in a wide variety of organisms, including nematodes, plants,…”
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MicroRNA expression signature of human sarcomas by Subramanian, S, Lui, W O, Lee, C H, Espinosa, I, Nielsen, T O, Heinrich, M C, Corless, C L, Fire, A Z, van de Rijn, M

“…MicroRNAs (miRNAs) are ∼22 nucleotide-long noncoding RNAs involved in several biological processes including development, differentiation and proliferation…”
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Specific interference by ingested dsRNA by Timmons, Lisa, Fire, Andrew

“…A genetic interference phenomenon in the nematode Caenorhabditis elegans has been described in which expression of an individual gene can be specifically…”
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Gene silencing by double-stranded RNA by Fire, Andrew Z

“…Thanks to the Nobel Foundation for permission to publish this Lecture. We report here the Nobel Lecture delivered by Professor Andrew Z Fire. Together with the…”
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Ingestion of bacterially expressed dsRNAs can produce specific and potent genetic interference in Caenorhabditis elegans by Timmons, L, Court, D L, Fire, A

“…Genetic interference mediated by double-stranded RNA (RNAi) has been a valuable tool in the analysis of gene function in Caenorhabditis elegans. Here we report…”
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Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans by Fire, Andrew, Xu, SiQun, Montgomery, Mary K, Kostas, Steven A, Driver, Samuel E, Mello, Craig C

“…Experimental introduction of RNA into cells can be used in certain biological systems to interfere with the function of an endogenous gene,. Such effects have…”
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Essential roles for Caenorhabditis elegans lamin gene in nuclear organization, cell cycle progression, and spatial organization of nuclear pore complexes by Liu, J, Rolef Ben-Shahar, T, Riemer, D, Treinin, M, Spann, P, Weber, K, Fire, A, Gruenbaum, Y

“…Caenorhabditis elegans has a single lamin gene, designated lmn-1 (previously termed CeLam-1). Antibodies raised against the lmn-1 product (Ce-lamin) detected a…”
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Overlapping roles of two Hox genes and the exd ortholog ceh-20 in diversification of the C. elegans postembryonic mesoderm by Liu, J, Fire, A

“…Members of the Hox family of homeoproteins and their cofactors play a central role in pattern formation of all germ layers. During postembryonic development of…”
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Rolling Replication of Short DNA Circles by Fire, Andrew, Xu, Si-Qun

“…Natural genes and proteins often contain tandemly repeated sequence motifs that dramatically increase physiological specificity and activity. Given the…”
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Chromatin silencing and the maintenance of a functional germline in Caenorhabditis elegans by Kelly, W G, Fire, A

“…The germline of the nematode Caenorhabditis elegans exhibits a remarkable ability to specifically silence transgenic DNA. We have shown that this silencing…”
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Soma-germline asymmetry in the distributions of embryonic RNAs in Caenorhabditis elegans by SEYDOUX, G, FIRE, A

“…Early embryogenesis in Caenorhabditis elegans is characterized by a series of unequal cleavages that mark the stepwise separation of somatic and germ lineages…”
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Double-stranded RNA as a mediator in sequence-specific genetic silencing and co-suppression by Montgomery, Mary K, Fire, Andrew

“…Many fundamental natural processes have been uncovered not by pre-planned scientific enquiry, but serendipitously by engineers and scientists who observed…”
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Regulation of apoptosis by C. elegans CED-9 in the absence of the C-terminal transmembrane domain by Tan, F J, Fire, A Z, Hill, R B

“…Bcl-2 proteins regulate apoptosis in organisms as diverse as mammals and nematodes. These proteins are often localized at mitochondria by a C-terminal…”
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RECOGNITION AND SILENCING OF REPEATED DNA by Hsieh, Jenny, Fire, Andrew

“…Mechanisms for repetition of DNA pose both opportunities and challenges to a functional genome: opportunities for increasing gene expression by amplification…”
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Sequence Requirements for Myosin Gene Expression and Regulation in Caenorhabditis elegans by Okkema, P. G, Harrison, S. W, Plunger, V, Aryana, A, Fire, A

“…Four Caenorhabditis elegans genes encode muscle-type specific myosin heavy chain isoforms: myo-1 and myo-2 are expressed in the pharyngeal muscles; unc-54 and…”
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The RING finger/B-box factor TAM-1 and a retinoblastoma-like protein LIN-35 modulate context-dependent gene silencing in Caenorhabditis elegans by Hsieh, J, Liu, J, Kostas, S A, Chang, C, Sternberg, P W, Fire, A

“…Context-dependent gene silencing is used by many organisms to stably modulate gene activity for large chromosomal regions. We have used tandem array transgenes…”
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Repression of gene expression in the embryonic germ lineage of C. elegans by Seydoux, Geraldine, Mello, Craig C, Pettitt, Jonathan, Wood, William B, Priess, James R, Fire, Andrew

“…The distinction between soma and germline was recognized more than a century ago: somatic cells form the body of an organism, whereas germ cells serve to…”
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The Caenorhabditis elegans NK-2 class homeoprotein CEH-22 is involved in combinatorial activation of gene expression in pharyngeal muscle by OKKEMA, P. G, FIRE, A

“…The pharyngeal muscles of Caenorhabditis elegans are single sarcomere muscles used for feeding. Like vertebrate cardiac and smooth muscles, C. elegans…”
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Identification and molecular-genetic characterization of a LAMP/CD68-like protein from Caenorhabditis elegans by Kostich, M, Fire, A, Fambrough, D M

“…Lysosome associated membrane proteins (LAMPs) constitute a family of vertebrate proteins located predominantly in lysosomes, with lesser amounts present in…”
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347: Generation of Genetically Engineered Low-Antigenicity MHC I Knock-Down Human Embryonic Stem Cells To Prevent Immune Rejection by Deuse, T, Seifert, M, Fire, A, Phillips, N, Kay, M, Reichenspurner, H, Robbins, R.C, Schrepfer, S

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