Search Results - "Fiorito, Jole"

Synaptic Therapy in Alzheimer’s Disease: A CREB-centric Approach by Teich, Andrew F., Nicholls, Russell E., Puzzo, Daniela, Fiorito, Jole, Purgatorio, Rosa, Fa’, Mauro, Arancio, Ottavio

“…Therapeutic attempts to cure Alzheimer’s disease (AD) have failed, and new strategies are desperately needed. Motivated by this reality, many laboratories…”
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Synaptic and memory dysfunction induced by tau oligomers is rescued by up-regulation of the nitric oxide cascade by Acquarone, Erica, Argyrousi, Elentina K, van den Berg, Manon, Gulisano, Walter, Fà, Mauro, Staniszewski, Agnieszka, Calcagno, Elisa, Zuccarello, Elisa, D'Adamio, Luciano, Deng, Shi-Xian, Puzzo, Daniela, Arancio, Ottavio, Fiorito, Jole

“…Soluble aggregates of oligomeric forms of tau protein (oTau) have been associated with impairment of synaptic plasticity and memory in Alzheimer's disease…”
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Antiangiogenic Effect of (±)-Haloperidol Metabolite II Valproate Ester [(±)-MRJF22] in Human Microvascular Retinal Endothelial Cells by Olivieri, Melania, Amata, Emanuele, Vinciguerra, Shila, Fiorito, Jole, Giurdanella, Giovanni, Drago, Filippo, Caporarello, Nunzia, Prezzavento, Orazio, Arena, Emanuela, Salerno, Loredana, Rescifina, Antonio, Lupo, Gabriella, Anfuso, Carmelina Daniela, Marrazzo, Agostino

“…(±)-MRJF22 [(±)-2], a novel prodrug of haloperidol metabolite II (sigma-1 receptor antagonist/sigma-2 receptor agonist ligand) obtained by conjugation to…”
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Correction: Synaptic and memory dysfunction induced by tau oligomers is rescued by up-regulation of the nitric oxide cascade by Acquarone, Erica, Argyrousi, Elentina K, van den Berg, Manon, Gulisano, Walter, Fà, Mauro, Staniszewski, Agnieszka, Calcagno, Elisa, Zuccarello, Elisa, D'Adamio, Luciano, Deng, Shi-Xian, Puzzo, Daniela, Arancio, Ottavio, Fiorito, Jole

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Development of novel phosphodiesterase 5 inhibitors for the therapy of Alzheimer’s disease by Zuccarello, Elisa, Acquarone, Erica, Calcagno, Elisa, Argyrousi, Elentina K., Deng, Shi-Xian, Landry, Donald W., Arancio, Ottavio, Fiorito, Jole

“…[Display omitted] Nitric oxide (NO) is a gaseous molecule that plays a multifactorial role in several cellular processes. In the central nervous system, the NO…”
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Identification of a Novel 1,2,3,4-Tetrahydrobenzo[b][1,6]naphthyridine Analogue as a Potent Phosphodiesterase 5 Inhibitor with Improved Aqueous Solubility for the Treatment of Alzheimer’s Disease by Fiorito, Jole, Vendome, Jeremie, Saeed, Faisal, Staniszewski, Agnieszka, Zhang, Hong, Yan, Shijun, Deng, Shi-Xian, Arancio, Ottavio, Landry, Donald W

“…Phosphodiesterase 5 (PDE5) hydrolyzes cyclic guanosine monophosphate (cGMP) leading to increased levels of the cAMP response element binding protein (CREB), a…”
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Optimizing metabolic stability of phosphodiesterase 5 inhibitors: Discovery of a potent N-(pyridin-3-ylmethyl)quinoline derivative targeting synaptic plasticity by Zuccarello, Elisa, Zhang, Hong, Acquarone, Erica, Pham, Dang, Staniszewski, Anna, Deng, Shi-Xian, Landry, Donald W., Arancio, Ottavio, Fiorito, Jole

“…[Display omitted] Phosphodiesterase 5 (PDE5) is a cyclic guanosine monophosphate-degrading enzyme involved in numerous biological pathways. Inhibitors of PDE5…”
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Histone Acetyltransferase (HAT) Activator, YF2, Modulates the p53:BCL6 Axis and Antigen Presentation in Diffuse Large B-Cell Lymphomas by Estrella, Brian, Liu, Yuxuan, Ricker, Edd C, Pazos, Manuel A, Fiorito, Jole, Zuccarello, Elisa, Calcagno, Elisa, Honig, Barry, Arancio, Ottavio, Amengual, Jennifer E.

“…A hallmark of DLBCL is epigenetic derangements characterized by monoallelic mutations in histone acetyltransferases (HATs); EP300 (p300) and CREBBP (CBP). The…”
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PDE5 Exists in Human Neurons and is a Viable Therapeutic Target for Neurologic Disease by Teich, Andrew F, Sakurai, Mikako, Patel, Mitesh, Holman, Cameron, Saeed, Faisal, Fiorito, Jole, Arancio, Ottavio

“…Phosphodiesterase 5 (PDE5) is a critical component of the cGMP-PKG axis of cellular signaling in neurons, and inhibition of PDE5 has been shown to be…”
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PDE5 inhibitors against synaptic and cognitive impairment in Alzheimer’s disease and related dementia by Arancio, Ottavio, Zuccarello, Elisa, Fiorito, Jole, Acquarone, Erica, Argyrousi, Elentina, Staniszewski, Agnieszka, Calcagno, Elisa, Puzzo, Daniela, Deng, Shi‐Xian, Landry, Donald

“…Background Gene transcription mechanisms leading to synaptic plasticity and memory formation, including phosphorylation of the transcription factor CREB, are…”
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Synthesis of quinoline derivatives: Discovery of a potent and selective phosphodiesterase 5 inhibitor for the treatment of Alzheimer's disease by Fiorito, Jole, Saeed, Faisal, Zhang, Hong, Staniszewski, Agnieszka, Feng, Yan, Francis, Yitshak I., Rao, Sudha, Thakkar, Devarshi M., Deng, Shi-Xian, Landry, Donald W., Arancio, Ottavio

“…Phosphodiesterase type 5 (PDE5) mediates the degradation of cGMP in a variety of tissues including brain. Recent studies have demonstrated the importance of…”
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Strategy for Overcoming Crebbp and EP300 Mutations in Lymphoma: Development of First-in-Class HAT Activators by Liu, Yuxuan, Fiorito, Jole, Gonzalez, Yulissa, Estrella, Brian, Calcagno, Elisa, Zuccarello, Elisa, Hwang, Howook, Honig, Barry, Deng, Shixian, Landry, Donald, O'Connor, Owen A., Arancio, Ottavio, Amengual, Jennifer E

“…Epigenetic dysregulation is a hallmark of germinal center derived B cell lymphomas. In particular, the monoallelic mutations in histone acetyltransferases…”
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Haloperidol metabolite II prodrug: Asymmetric synthesis and biological evaluation on rat C6 glioma cells by Sozio, Piera, Fiorito, Jole, Di Giacomo, Viviana, Di Stefano, Antonio, Marinelli, Lisa, Cacciatore, Ivana, Cataldi, Amelia, Pacella, Stephanie, Turkez, Hasan, Parenti, Carmela, Rescifina, Antonio, Marrazzo, Agostino

“…In a previous work we reported the antiproliferative effects of (±)-MRJF4, a novel haloperidol metabolite II (HP-mII) (a sigma-1 antagonist and sigma-2…”
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Development of First-in-Class Histone Acetyltransferase (HAT) Activators for Precision Targeting of Epigenetic Derangements in Lymphoma by Liu, Yuxuan, Fiorito, Jole, Gonzalez, Yulissa, Zuccarello, Elisa, Calcagno, Elisa, Mazzeo, Adolfo, Abshiru, Nebiyu Ali, Camarillo, Jeannie, Kelleher, Neil L, Qiao, Changhong, Nandakumar, Renu, Serge, Cremers, Deng, Shixian, Landry, Donald, O'Connor, Owen A., Arancio, Ottavio, Amengual, Jennifer E

“…Monoalleleic inactivating mutations in histone acetyltransferase (HAT) enzymes promote lymphomagenesis in germinal center derived B-cell lymphomas, follicular…”
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Antiproliferative activity of phenylbutyrate ester of haloperidol metabolite II [(±)-MRJF4] in prostate cancer cells by Marrazzo, Agostino, Fiorito, Jole, Zappalà, Laura, Prezzavento, Orazio, Ronsisvalle, Simone, Pasquinucci, Lorella, Scoto, Giovanna M., Bernardini, Renato, Ronsisvalle, Giuseppe

“…Complex mechanisms of prostate cancer progression prompt to novel therapeutic strategies concerning a combination of drugs or of single molecules able to…”
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Effect of MRJF4 on C6 Glioma Cells Proliferation and Migration by Pacella, Stephanie, Fiorito, Jole, Cacciatore, Ivana, di Giacomo, Viviana, Patruno, Antonia, Rapino, Monica, Di Stefano, Antonio, Marinelli, Lisa, Fornasari, Erika, Cataldi, Amelia, Prezzavento, Orazio, Marrazzo, Agostino

“…MRJF4, a novel haloperidol metabolite II prodrug, was obtained through the esterification of the secondary hydroxyl group of haloperidol metabolite II with…”
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