Search Results - "Fiorillo, Alyson"

Muscle Weakness in Myositis: MicroRNA‐Mediated Dystrophin Reduction in a Myositis Mouse Model and Human Muscle Biopsies by Kinder, Travis B., Heier, Christopher R., Tully, Christopher B., Van der Muelen, Jack H., Hoffman, Eric P., Nagaraju, Kanneboyina, Fiorillo, Alyson A.

“…Objective Muscle inflammation is a feature in myositis and Duchenne muscular dystrophy (DMD). Autoimmune mechanisms are thought to contribute to muscle…”
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Serum miRNAs Are Pharmacodynamic Biomarkers Associated With Therapeutic Response in Pediatric Inflammatory Bowel Disease by Batra, Suruchi K, Heier, Christopher R, Diaz-Calderon, Lina, Tully, Christopher B, Fiorillo, Alyson A, van den Anker, John, Conklin, Laurie S

“…Abstract Background We sought to identify microRNAs (miRNAs) associated with response to anti-TNF-α or glucocorticoids in children with inflammatory bowel…”
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TNF-α-Induced microRNAs Control Dystrophin Expression in Becker Muscular Dystrophy by Fiorillo, Alyson A., Heier, Christopher R., Novak, James S., Tully, Christopher B., Brown, Kristy J., Uaesoontrachoon, Kitipong, Vila, Maria C., Ngheim, Peter P., Bello, Luca, Kornegay, Joe N., Angelini, Corrado, Partridge, Terence A., Nagaraju, Kanneboyina, Hoffman, Eric P.

“…The amount and distribution of dystrophin protein in myofibers and muscle is highly variable in Becker muscular dystrophy and in exon-skipping trials for…”
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Myoblasts and macrophages are required for therapeutic morpholino antisense oligonucleotide delivery to dystrophic muscle by Novak, James S., Hogarth, Marshall W., Boehler, Jessica F., Nearing, Marie, Vila, Maria C., Heredia, Raul, Fiorillo, Alyson A., Zhang, Aiping, Hathout, Yetrib, Hoffman, Eric P., Jaiswal, Jyoti K., Nagaraju, Kanneboyina, Cirak, Sebahattin, Partridge, Terence A.

“…Exon skipping is a promising therapeutic strategy for Duchenne muscular dystrophy (DMD), employing morpholino antisense oligonucleotides (PMO-AO) to exclude…”
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Estrogen Receptor, Inflammatory, and FOXO Transcription Factors Regulate Expression of Myasthenia Gravis-Associated Circulating microRNAs by Fiorillo, Alyson A, Heier, Christopher R, Huang, Yu-Fang, Tully, Christopher B, Punga, Tanel, Punga, Anna Rostedt

“…MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate important intracellular biological processes. In myasthenia gravis (MG), a disease-specific…”
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The glucocorticoid receptor acts locally to protect dystrophic muscle and heart during disease by Oliver, Trinitee, Nguyen, Nhu Y, Tully, Christopher B, McCormack, Nikki M, Sun, Christina M, Fiorillo, Alyson A, Heier, Christopher R

“…Absence of dystrophin results in muscular weakness, chronic inflammation and cardiomyopathy in Duchenne muscular dystrophy (DMD). Pharmacological…”
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The X‐linked Becker muscular dystrophy (bmx) mouse models Becker muscular dystrophy via deletion of murine dystrophin exons 45–47 by Heier, Christopher R., McCormack, Nikki M., Tully, Christopher B., Novak, James S., Newell‐Stamper, Breanne L., Russell, Alan J., Fiorillo, Alyson A.

“…Background Becker muscular dystrophy (BMD) is a genetic neuromuscular disease of growing importance caused by in‐frame, partial loss‐of‐function mutations in…”
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HDAC6 Deacetylates HMGN2 to Regulate Stat5a Activity and Breast Cancer Growth by Medler, Terry R, Craig, Justin M, Fiorillo, Alyson A, Feeney, Yvonne B, Harrell, J Chuck, Clevenger, Charles V

“…Stat5a is a transcription factor utilized by several cytokine/hormone receptor signaling pathways that promotes transcription of genes associated with…”
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Deletion of miR-146a enhances therapeutic protein restoration in model of dystrophin exon skipping by McCormack, Nikki M., Calabrese, Kelsey A., Sun, Christina M., Tully, Christopher B., Heier, Christopher R., Fiorillo, Alyson A.

“…Duchenne muscular dystrophy (DMD) is a progressive muscle disease caused by the absence of dystrophin protein. One current DMD therapeutic strategy, exon…”
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Morpholino‐induced exon skipping stimulates cell‐mediated and humoral responses to dystrophin in mdx mice by Vila, Maria C, Novak, James S, Benny Klimek, Margaret, Li, Ning, Morales, Melissa, Fritz, Alexander G, Edwards, Katie, Boehler, Jessica F, Hogarth, Marshall W, Kinder, Travis B, Zhang, Aiping, Mazala, Davi, Fiorillo, Alyson A, Douglas, Bonnie, Chen, Yi‐Wen, van den Anker, John, Lu, Qi L, Hathout, Yetrib, Hoffman, Eric P, Partridge, Terence A, Nagaraju, Kanneboyina

“…Exon skipping is a promising genetic therapeutic strategy for restoring dystrophin expression in the treatment of Duchenne muscular dystrophy (DMD). The…”
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Muscle miRNAome shows suppression of chronic inflammatory miRNAs with both prednisone and vamorolone by Fiorillo, Alyson A, Tully, Christopher B, Damsker, Jesse M, Nagaraju, Kanneboyina, Hoffman, Eric P, Heier, Christopher R

“…Corticosteroids are highly prescribed and effective anti-inflammatory drugs but the burden of side effects with chronic use significantly detracts from patient…”
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Vamorolone improves Becker muscular dystrophy and increases dystrophin protein in bmx model mice by McCormack, Nikki M., Nguyen, Nhu Y., Tully, Christopher B., Oliver, Trinitee, Fiorillo, Alyson A., Heier, Christopher R.

“…There is no approved therapy for Becker muscular dystrophy (BMD), a genetic muscle disease caused by in-frame dystrophin deletions. We previously developed the…”
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Editorial: Genome and transcriptome editing to understand and treat neuromuscular diseases by Maruyama, Rika, Fiorillo, Alyson, Heier, Christopher, Duan, Dongsheng, Yokota, Toshifumi

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Identification of Pathway-Specific Serum Biomarkers of Response to Glucocorticoid and Infliximab Treatment in Children with Inflammatory Bowel Disease by Heier, Christopher R, Fiorillo, Alyson A, Chaisson, Ellen, Gordish-Dressman, Heather, Hathout, Yetrib, Damsker, Jesse M, Hoffman, Eric P, Conklin, Laurie S

“…Serum biomarkers may serve to predict early response to therapy, identify relapse, and facilitate drug development in inflammatory bowel disease (IBD)…”
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Vamorolone targets dual nuclear receptors to treat inflammation and dystrophic cardiomyopathy by Heier, Christopher R, Yu, Qing, Fiorillo, Alyson A, Tully, Christopher B, Tucker, Asya, Mazala, Davi A, Uaesoontrachoon, Kitipong, Srinivassane, Sadish, Damsker, Jesse M, Hoffman, Eric P, Nagaraju, Kanneboyina, Spurney, Christopher F

“…Cardiomyopathy is a leading cause of death for Duchenne muscular dystrophy. Here, we find that the mineralocorticoid receptor (MR) and glucocorticoid receptor…”
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Vamorolone, a dissociative steroidal compound, reduces collagen antibody-induced joint damage and inflammation when administered after disease onset by Damsker, Jesse M., Cornish, Michaelyn R., Kanneboyina, Priya, Kanneboyina, Ila, Yu, Qing, Lipson, Rachel, Phadke, Aditi, Knoblach, Susan M., Panchapakesan, Karuna, Morales, Melissa, Fiorillo, Alyson A., Partridge, Terence, Nagaraju, Kanneboyina

“…Objective and design The objective of this study was to assess the effect of vamorolone, a first-in-class dissociative steroidal compound, to inhibit…”
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Author Correction: Myoblasts and macrophages are required for therapeutic morpholino antisense oligonucleotide delivery to dystrophic muscle by Novak, James S., Hogarth, Marshall W., Boehler, Jessica F., Nearing, Marie, Vila, Maria C., Heredia, Raul, Fiorillo, Alyson A., Zhang, Aiping, Hathout, Yetrib, Hoffman, Eric P., Jaiswal, Jyoti K., Nagaraju, Kanneboyina, Cirak, Sebahattin, Partridge, Terence A.

“…The originally published version of this Article contained an error in Figure 6. In panel b, the top graph (BrdU 21–24d) and the bottom graph (BrdU 28–31d)…”
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Author Correction: Myoblasts and macrophages are required for therapeutic morpholino antisense oligonucleotide delivery to dystrophic muscle by Novak, James S., Hogarth, Marshall W., Boehler, Jessica F., Nearing, Marie, Vila, Maria C., Heredia, Raul, Fiorillo, Alyson A., Zhang, Aiping, Hathout, Yetrib, Hoffman, Eric P., Jaiswal, Jyoti K., Nagaraju, Kanneboyina, Cirak, Sebahattin, Partridge, Terence A.

“…In the original version of this Article, financial support was not fully acknowledged. The PDF and HTML versions of the Article have now been corrected to…”
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Interrogation of Dystrophin and Dystroglycan Complex Protein Turnover After Exon Skipping Therapy by Novak, James S, Spathis, Rita, Dang, Utkarsh J, Fiorillo, Alyson A, Hindupur, Ravi, Tully, Christopher B, Mázala, Davi A G, Canessa, Emily, Brown, Kristy J, Partridge, Terence A, Hathout, Yetrib, Nagaraju, Kanneboyina

“…Recently, the Food and Drug Administration granted accelerated approvals for four exon skipping therapies -Eteplirsen, Golodirsen, Viltolarsen, and Casimersen…”
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The Prolactin Receptor Transactivation Domain Is Associated with Steroid Hormone Receptor Expression and Malignant Progression of Breast Cancer by Fiorillo, Alyson A, Medler, Terry R, Feeney, Yvonne B, Wetz, Suzanne M, Tommerdahl, Kalie L, Clevenger, Charles V

“…The polypeptide hormone prolactin (PRL) stimulates breast epithelial cell growth, differentiation, and motility through its cognate receptor, PRLr. PRLr is…”
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