Search Results - "Fiore, Anna Di"

Thermostable Carbonic Anhydrases in Biotechnological Applications by Di Fiore, Anna, Alterio, Vincenzo, Monti, Simona M, De Simone, Giuseppina, D'Ambrosio, Katia

“…Carbonic anhydrases are ubiquitous metallo-enzymes which catalyze the reversible hydration of carbon dioxide in bicarbonate ions and protons. Recent years have…”
Get full text

Protective Role of Carbonic Anhydrases III and VII in Cellular Defense Mechanisms upon Redox Unbalance by De Simone, Giuseppina, Scaloni, Andrea, Monti, Daria Maria, Di Fiore, Anna, Monti, Simona Maria

“…Under oxidative stress conditions, several constitutive cellular defense systems are activated, which involve both enzymatic systems and molecules with…”
Get full text

Biochemical and structural characterisation of a protozoan beta-carbonic anhydrase from Trichomonas vaginalis by Urbański, Linda J., Di Fiore, Anna, Azizi, Latifeh, Hytönen, Vesa P., Kuuslahti, Marianne, Buonanno, Martina, Monti, Simona M., Angeli, Andrea, Zolfaghari Emameh, Reza, Supuran, Claudiu T., De Simone, Giuseppina, Parkkila, Seppo

“…We report the biochemical and structural characterisation of a beta-carbonic anhydrase (β-CA) from Trichomonas vaginalis, a unicellular parasite responsible…”
Get full text

Carbonic anhydrase inhibitors as emerging drugs for the treatment of obesity by Supuran, Claudiu T, Di Fiore, Anna, De Simone, Giuseppina

“…Obesity is a widespread disease in both the developed and developing world. Few pharmacological approaches for its treatment exist at this time. This review…”
Get more information

Hydrophobic Substituents of the Phenylmethylsulfamide Moiety Can Be Used for the Development of New Selective Carbonic Anhydrase Inhibitors by Alterio, Vincenzo, Supuran, Claudiu T., Trapencieris, Pēteris, Vozny, Igor, Ivanova, Jekaterina, Di Fiore, Anna, Monti, Simona Maria, Pizika, Ginta, De Simone, Giuseppina, Zalubovskis, Raivis

“…A new series of compounds containing a sulfamide moiety as zinc-binding group (ZBG) has been synthesized and tested for determining inhibitory properties…”
Get full text

Multiple Binding Modes of Inhibitors to Carbonic Anhydrases: How to Design Specific Drugs Targeting 15 Different Isoforms? by Alterio, Vincenzo, Di Fiore, Anna, D’Ambrosio, Katia, Supuran, Claudiu T, De Simone, Giuseppina

“…Alterio et al examine the structural studies of alpha-carbonic anhydrases, with regard to several binding states of inhibitors and drugs that target 15 unique…”
Get full text

Inhibition of carbonic anhydrase IX targets primary tumors, metastases, and cancer stem cells: Three for the price of one by Supuran, Claudiu T., Alterio, Vincenzo, Di Fiore, Anna, D’ Ambrosio, Katia, Carta, Fabrizio, Monti, Simona Maria, Simone, Giuseppina

“…Human carbonic anhydrase (CA) IX is a tumor‐associated protein, since it is scarcely present in normal tissues, but highly overexpressed in a large number of…”
Get full text

Structure–Activity Relationships of C-17 Cyano-Substituted Estratrienes as Anticancer Agents by Leese, Mathew P, Jourdan, Fabrice L, Gaukroger, Keira, Mahon, Mary F, Newman, Simon P, Foster, Paul A, Stengel, Chloe, Regis-Lydi, Sandra, Ferrandis, Eric, Fiore, Anna Di, De Simone, Giuseppina, Supuran, Claudiu T, Purohit, Atul, Reed, Michael J, Potter, Barry V. L

“…The synthesis, SAR, and preclinical evaluation of 17-cyanated 2-substituted estra-1,3,5(10)-trienes as anticancer agents are discussed…”
Get full text

Post-translational modifications in tumor-associated carbonic anhydrases by Di Fiore, Anna, Supuran, Claudiu T., Scaloni, Andrea, De Simone, Giuseppina

“…Human carbonic anhydrases IX (hCA IX) and XII (hCA XII) are two proteins associated with tumor formation and development. These enzymes have been largely…”
Get full text

Crystal Structure of the Catalytic Domain of the Tumor-Associated Human Carbonic Anhydrase IX by Alterio, Vincenzo, Hilvo, Mika, Di Fiore, Anna, Supuran, Claudiu T., Pan, Peiwen, Parkkila, Seppo, Scaloni, Andrea, Pastorek, Jaromir, Pastorekova, Silvia, Pedone, Carlo, Scozzafava, Andrea, Monti, Simona Maria, De Simone, Giuseppina, Sly, William S.

“…Carbonic anhydrase (CA) IX is a plasma membrane-associated member of the α-CA enzyme family, which is involved in solid tumor acidification. It is a marker of…”
Get full text

Benzoxaborole as a new chemotype for carbonic anhydrase inhibition by Alterio, Vincenzo, Cadoni, Roberta, Esposito, Davide, Vullo, Daniela, Fiore, Anna Di, Monti, Simona Maria, Caporale, Andrea, Ruvo, Menotti, Sechi, Mario, Dumy, Pascal, Supuran, Claudiu T, De Simone, Giuseppina, Winum, Jean-Yves

“…In this paper we report the synthesis of a series of benzoxaborole derivatives, their inhibition properties against some carbonic anhydrases (CAs), recognized…”
Get more information

Biochemical and Structural Insights into the Winged Helix Domain of P150, the Largest Subunit of the Chromatin Assembly Factor 1 by Ayoub, Joëlle, Buonanno, Martina, Di Fiore, Anna, De Simone, Giuseppina, Monti, Simona Maria

“…The Chromatin Assembly Factor 1 is a heterotrimeric complex responsible for the nucleosome assembly during DNA replication and DNA repair. In humans, the…”
Get full text

Human carbonic anhydrases and post-translational modifications: a hidden world possibly affecting protein properties and functions by Di Fiore, Anna, Supuran, Claudiu T., Scaloni, Andrea, De Simone, Giuseppina

“…Human carbonic anhydrases (CAs) have become a well-recognized target for the design of inhibitors and activators with biomedical applications. Accordingly, an…”
Get full text

α-CAs from Photosynthetic Organisms by Langella, Emma, Di Fiore, Anna, Alterio, Vincenzo, Monti, Simona Maria, De Simone, Giuseppina, D’Ambrosio, Katia

“…Carbonic anhydrases (CAs) are ubiquitous enzymes that catalyze the reversible carbon dioxide hydration reaction. Among the eight different CA classes existing…”
Get full text

Probing Molecular Interactions between Human Carbonic Anhydrases (hCAs) and a Novel Class of Benzenesulfonamides by Bruno, Elvira, Buemi, Maria Rosa, Di Fiore, Anna, De Luca, Laura, Ferro, Stefania, Angeli, Andrea, Cirilli, Roberto, Sadutto, Daniele, Alterio, Vincenzo, Monti, Simona Maria, Supuran, Claudiu T, De Simone, Giuseppina, Gitto, Rosaria

“…On the basis of X-ray crystallographic studies of the complex of hCA II with 4-(3,4-dihydro-1H-isoquinoline-2-carbonyl)­benzenesulfonamide (3) (PDB code 4Z1J),…”
Get full text

Biochemical Characterization of CA IX, One of the Most Active Carbonic Anhydrase Isozymes by Hilvo, Mika, Baranauskiene, Lina, Salzano, Anna Maria, Scaloni, Andrea, Matulis, Daumantas, Innocenti, Alessio, Scozzafava, Andrea, Monti, Simona Maria, Di Fiore, Anna, De Simone, Giuseppina, Lindfors, Mikaela, Jänis, Janne, Valjakka, Jarkko, Pastoreková, Silvia, Pastorek, Jaromir, Kulomaa, Markku S., Nordlund, Henri R., Supuran, Claudiu T., Parkkila, Seppo

“…Carbonic anhydrase IX (CA IX) is an exceptional member of the CA protein family; in addition to its classical role in pH regulation, it has also been proposed…”
Get full text

Are carbonic anhydrase inhibitors suitable for obtaining antiobesity drugs? by De Simone, Giuseppina, Di Fiore, Anna, Supuran, Claudiu T

“…Obesity is widespread disease both in the developed and developing world, which currently affects over 300 million individuals worldwide and is associated with…”
Get more information

The Crystal Structure of a hCA VII Variant Provides Insights into the Molecular Determinants Responsible for Its Catalytic Behavior by Buonanno, Martina, Di Fiore, Anna, Langella, Emma, D'Ambrosio, Katia, Supuran, Claudiu T, Monti, Simona Maria, De Simone, Giuseppina

“…Although important progress has been achieved in understanding the catalytic mechanism of Carbonic Anhydrases, a detailed picture of all factors influencing…”
Get full text

Insights into the role of reactive sulfhydryl groups of Carbonic Anhydrase III and VII during oxidative damage by Monti, Daria M., De Simone, Giuseppina, Langella, Emma, Supuran, Claudiu T., Di Fiore, Anna, Monti, Simona M.

“…Carbonic anhydrases (CAs) III and VII are two cytosolic isoforms of the α-CA family which catalyze the physiological reaction of carbon dioxide hydration to…”
Get full text

Inhibition of the β-carbonic anhydrase from the protozoan pathogen Trichomonas vaginalis with sulphonamides by Urbański, Linda J, Angeli, Andrea, Hytönen, Vesa P, Di Fiore, Anna, De Simone, Giuseppina, Parkkila, Seppo, Supuran, Claudiu T

“…Sulphonamides and their isosteres are classical inhibitors of the carbonic anhydrase (CAs, EC 4.2.1.1) metalloenzymes. The protozoan pathogen encodes two such…”
Get full text