Search Results - "Fiona Ross"

Global nurse shortages-the facts, the impact and action for change by Drennan, Vari M, Ross, Fiona

“…Nurses comprise half the global health workforce. A nine million shortage estimated in 2014 is predicted to decrease by two million by 2030 but…”
Get full text

AMP‐activated protein kinase: a cellular energy sensor that comes in 12 flavours by Ross, Fiona A., MacKintosh, Carol, Hardie, D. Grahame

“…The AMP‐activated protein kinase (AMPK) is a sensor of cellular energy status that is expressed in essentially all eukaryotic cells, suggesting that it arose…”
Get full text

AMPK: a nutrient and energy sensor that maintains energy homeostasis by Hardie, D. Grahame, Ross, Fiona A., Hawley, Simon A.

“…Key Points AMP-activated protein kinase (AMPK) occurs as heterotrimeric protein complexes that monitor cellular energy status by sensing the concentrations of…”
Get full text

AMP Is a True Physiological Regulator of AMP-Activated Protein Kinase by Both Allosteric Activation and Enhancing Net Phosphorylation by Gowans, Graeme J., Hawley, Simon A., Ross, Fiona A., Hardie, D. Grahame

“…While allosteric activation of AMPK is triggered only by AMP, binding of both ADP and AMP has been reported to promote phosphorylation and inhibit…”
Get full text

Differential regulation by AMP and ADP of AMPK complexes containing different γ subunit isoforms by Ross, Fiona A, Jensen, Thomas E, Hardie, D Grahame

“…The γ subunits of heterotrimeric AMPK complexes contain the binding sites for the regulatory adenine nucleotides AMP, ADP and ATP. We addressed whether…”
Get more information

Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells by Hawley, Simon A, Ross, Fiona A, Gowans, Graeme J, Tibarewal, Priyanka, Leslie, Nicholas R, Hardie, D Grahame

“…The insulin/IGF-1 (insulin-like growth factor 1)-activated protein kinase Akt (also known as protein kinase B) phosphorylates Ser487 in the 'ST loop'…”
Get more information

Raw Life and Respectability: Poverty and Everyday Life in a Postapartheid Community by Ross, Fiona C.

“…Through close ethnographic attention to modes of world making among people living in a very impoverished community in Cape Town, South Africa, in this paper I…”
Get full text

The interplay between diet and the gut microbiome: implications for health and disease by Ross, Fiona C., Patangia, Dhrati, Grimaud, Ghjuvan, Lavelle, Aonghus, Dempsey, Eugene M., Ross, R. Paul, Stanton, Catherine

“…Diet has a pivotal role in shaping the composition, function and diversity of the gut microbiome, with various diets having a profound impact on the stability,…”
Get full text

The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase by Hawley, Simon A., Fullerton, Morgan D., Ross, Fiona A., Schertzer, Jonathan D., Chevtzoff, Cyrille, Walker, Katherine J., Peggie, Mark W., Zibrova, Darya, Green, Kevin A., Mustard, Kirsty J., Kemp, Bruce E., Sakamoto, Kei, Steinberg, Gregory R., Hardie, D. Grahame

“…Salicylate, a plant product, has been in medicinal use since ancient times. More recently, it has been replaced by synthetic derivatives such as aspirin and…”
Get full text

A second-order witness: observing infant observers in South Africa by Ross, Fiona C.

“…Infant mental health is a new field in southern Africa. Some of its premises do not mesh neatly with local social forms and cultural precepts. Infant…”
Get full text

Still Unknown and Overlooked? Anthropologies of Childhood and Infancy in Southern Africa, 1995-2020 by Ross, Fiona C., Pentecost, Michelle

“…In 1995, Pamela Reynolds published a stringent critique of the lack of attention to children in southern African Anthropology. 'Not known because not looked…”
Get full text

Oxidative stress activates AMPK in cultured cells primarily by increasing cellular AMP and/or ADP by Auciello, F. Romana, Ross, Fiona A., Ikematsu, Naoko, Hardie, D. Grahame

“…•AMPK is activated by oxidative stress generated using glucose oxidase.•Activation is largely, but not solely, mediated by increases in AMP and/or…”
Get full text

Response to Commentary: 'Why are black South African students less likely to consider studying biological sciences?' by Ross, Fiona C

“…The Commentary 'Why are black South African students less likely to consider studying biological sciences?' offers a mistaken description of a problem which it…”
Get full text

Mechanism of Activation of AMPK by Cordycepin by Hawley, Simon A, Ross, Fiona A, Russell, Fiona M, Atrih, Abdelmadjid, Lamont, Douglas J, Hardie, D Grahame

“…Cordycepin (3'-deoxyadenosine) is a major bioactive agent in Cordyceps militaris, a fungus used in traditional Chinese medicine. It has been proposed to have…”
Get more information

Artificial intelligence technologies and compassion in healthcare: A systematic scoping review by Morrow, Elizabeth, Zidaru, Teodor, Ross, Fiona, Mason, Cindy, Patel, Kunal D, Ream, Melissa, Stockley, Rich

“…Advances in artificial intelligence (AI) technologies, together with the availability of big data in society, creates uncertainties about how these…”
Get full text

Minimal Residual Disease Assessed by Multiparameter Flow Cytometry in Multiple Myeloma: Impact on Outcome in the Medical Research Council Myeloma IX Study by RAWSTRON, Andy C, CHILD, J. Anthony, ROSS, Fiona M, COOK, Gordon, JACKSON, Graham H, MORGAN, Gareth J, OWEN, Roger G, DE TUTE, Ruth M, DAVIES, Faith E, GREGORY, Walter M, BELL, Sue E, SZUBERT, Alexander J, NAVARRO-COY, Nuria, DRAYSON, Mark T, FEYLER, Sylvia

“…To investigate the prognostic value of minimal residual disease (MRD) assessment in patients with multiple myeloma treated in the MRC (Medical Research…”
Get full text

Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders by Cross, Nicholas C P, Ernst, Thomas, Chase, Andrew J, Score, Joannah, Hidalgo-Curtis, Claire E, Bryant, Catherine, Jones, Amy V, Waghorn, Katherine, Zoi, Katerina, Ross, Fiona M, Reiter, Andreas, Hochhaus, Andreas, Drexler, Hans G, Duncombe, Andrew, Cervantes, Francisco, Oscier, David, Boultwood, Jacqueline, Grand, Francis H

“…Abnormalities of chromosome 7q are common in myeloid malignancies, but no specific target genes have yet been identified. Here, we describe the finding of…”
Get full text

Frequent loss-of-function mutations in the AMPK-α2 catalytic subunit suggest a tumour suppressor role in human skin cancers by Ross, Fiona A, Hawley, Simon A, Russell, Fiona M, Goodman, Nicola, Hardie, D Grahame

“…The AMP-activated protein kinase (AMPK) is a sensor of cellular energy status activated by increases in AMP or ADP relative to ATP. Once activated, it…”
Get more information

Use of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK Activation by Hawley, Simon A., Ross, Fiona A., Chevtzoff, Cyrille, Green, Kevin A., Evans, Ashleigh, Fogarty, Sarah, Towler, Mhairi C., Brown, Laura J., Ogunbayo, Oluseye A., Evans, A. Mark, Hardie, D. Grahame

“…A wide variety of agents activate AMPK, but in many cases the mechanisms remain unclear. We generated isogenic cell lines stably expressing AMPK complexes…”
Get full text

BAY-3827 and SBI-0206965: Potent AMPK Inhibitors That Paradoxically Increase Thr172 Phosphorylation by Hawley, Simon A, Russell, Fiona M, Ross, Fiona A, Hardie, D Grahame

“…AMP-activated protein kinase (AMPK) is the central component of a signalling pathway that senses energy stress and triggers a metabolic switch away from…”
Get full text