Search Results - "Finucane, Orla M"

Anti-TLR2 antibody triggers oxidative phosphorylation in microglia and increases phagocytosis of β-amyloid by Rubio-Araiz, Ana, Finucane, Orla M, Keogh, Samuel, Lynch, Marina A

“…Microglia are multifunctional cells that are primarily neuroprotective and a deficit in their functional integrity is likely to be a contributory factor in the…”
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Mechanisms of obesity-induced inflammation and insulin resistance: insights into the emerging role of nutritional strategies by McArdle, Maeve A, Finucane, Orla M, Connaughton, Ruth M, McMorrow, Aoibheann M, Roche, Helen M

“…Obesity and associated chronic inflammation initiate a state of insulin resistance (IR). The secretion of chemoattractants such as MCP-1 and MIF and of…”
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Dietary saturated fatty acids prime the NLRP3 inflammasome via TLR4 in dendritic cells-implications for diet-induced insulin resistance by Reynolds, Clare M., McGillicuddy, Fiona C., Harford, Karen A., Finucane, Orla M., Mills, Kingston H. G., Roche, Helen M.

“…Scope Inflammasome‐mediated inflammation is a critical regulator of obesity‐induced insulin resistance (IR). We hypothesized that saturated fatty acids (SFA)…”
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Macrophage migration inhibitory factor deficiency ameliorates high-fat diet induced insulin resistance in mice with reduced adipose inflammation and hepatic steatosis by Finucane, Orla M, Reynolds, Clare M, McGillicuddy, Fiona C, Harford, Karen A, Morrison, Martine, Baugh, John, Roche, Helen M

“…Macrophage infiltration is a critical determinant of high-fat diet induced adipose tissue inflammation and insulin resistance. The precise mechanisms…”
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The NLRP3 inflammasome modulates glycolysis by increasing PFKFB3 in an IL-1β-dependent manner in macrophages by Finucane, Orla M., Sugrue, Jamie, Rubio-Araiz, Ana, Guillot-Sestier, Marie-Victoire, Lynch, Marina A.

“…Inflammation and metabolism are intricately linked during inflammatory diseases in which activation of the nucleotide-binding domain–like receptors Family…”
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Monounsaturated fatty acid-enriched high-fat diets impede adipose NLRP3 inflammasome-mediated IL-1β secretion and insulin resistance despite obesity by Finucane, Orla M, Lyons, Claire L, Murphy, Aoife M, Reynolds, Clare M, Klinger, Rut, Healy, Niamh P, Cooke, Aoife A, Coll, Rebecca C, McAllan, Liam, Nilaweera, Kanishka N, O'Reilly, Marcella E, Tierney, Audrey C, Morine, Melissa J, Alcala-Diaz, Juan F, Lopez-Miranda, Jose, O'Connor, Darran P, O'Neill, Luke A, McGillicuddy, Fiona C, Roche, Helen M

“…Saturated fatty acid (SFA) high-fat diets (HFDs) enhance interleukin (IL)-1β-mediated adipose inflammation and insulin resistance. However, the mechanisms by…”
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Dietary substitution of SFA with MUFA within high-fat diets attenuates hyperinsulinaemia and pancreatic islet dysfunction by Ralston, Jessica C., Nguyen-Tu, Marie-Sophie, Lyons, Claire L., Cooke, Aoife A., Murphy, Aoife M., Falvey, Aidan, Finucane, Orla M., McGillicuddy, Fiona C., Rutter, Guy A., Roche, Helen M.

“…Preliminary evidence has suggested that high-fat diets (HFD) enriched with SFA, but not MUFA, promote hyperinsulinaemia and pancreatic hypertrophy with insulin…”
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Insights into the role of macrophage migration inhibitory factor in obesity and insulin resistance by Finucane, Orla M., Reynolds, Clare M., McGillicuddy, Fiona C., Roche, Helen M.

“…High-fat diet (HFD)-induced obesity has emerged as a state of chronic low-grade inflammation characterised by a progressive infiltration of immune cells,…”
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FTY720 Attenuates Infection-Induced Enhancement of Aβ Accumulation in APP/PS1 Mice by Modulating Astrocytic Activation by McManus, Róisín M., Finucane, Orla M, Wilk, Mieszko M., Mills, Kingston H. G., Lynch, Marina A.

“…It is well established that infection has a significant detrimental effect on patients with Alzheimer’s disease (AD), accelerating cognitive decline and, even…”
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Interactions between differential fatty acids and inflammatory stressors—impact on metabolic health by Murphy, Aoife M, Lyons, Claire L, Finucane, Orla M, Roche, Helen M

“…Abstract Current interest in obesity has established a clear link between diets high in fat and metabolic complications such as Type 2 Diabetes. Dietary fats…”
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A casein hydrolysate protects mice against high fat diet induced hyperglycemia by attenuating NLRP3 inflammasome-mediated inflammation and improving insulin signaling by Healy, Niamh P., Kirwan, Anna M., McArdle, Maeve A., Holohan, Kieran, Nongonierma, Alice B., Keane, Deirdre, Kelly, Stacey, Celkova, Lucia, Lyons, Claire L., McGillicuddy, Fiona C, Finucane, Orla M, Murray, Brian A., Kelly, Philip M., Brennan, Lorraine, FitzGerald, Richard J., Roche, Helen M.

“…Scope Activation of the nod‐like receptor protein 3 (NLRP3) inflammasome is required for IL‐1β release and is a key component of obesity‐induced inflammation…”
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Dietary saturated fatty acids prime the NLRP 3 inflammasome via TLR 4 in dendritic cells—implications for diet‐induced insulin resistance by Reynolds, Clare M., McGillicuddy, Fiona C., Harford, Karen A., Finucane, Orla M., Mills, Kingston H. G., Roche, Helen M.

“…Scope Inflammasome‐mediated inflammation is a critical regulator of obesity‐induced insulin resistance ( IR ). We hypothesized that saturated fatty acids ( SFA…”
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Monounsaturated Fatty Acid-Enriched High-Fat Diets Impede Adipose NLRP3 Inflammasome-Mediated IL-1[Beta] Secretion and Insulin Resistance Despite Obesity by Finucane, Orla M, Lyons, Claire L, Murphy, Aoife M, Reynolds, Clare M, Klinger, Rut, Healy, Niamh P, Cooke, Aoife A, Coll, Rebecca C, McAllan, Liam, Nilaweera, Kanishka N, O'Reilly, Marcella E, Tierney, Audrey C, Morine, Melissa J, Alcala-Diaz, Juan F, Lopez-Miranda, Jose, O'Connor, Darran P, O'Neill, Luke A, McGillicuddy, Fiona C, Roche, Helen M

“…Saturated fatty acid (SFA) high-fat diets (HFDs) enhance interleukin (IL)-1β-mediated adipose inflammation and insulin resistance. However, the mechanisms by…”
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Macrophage Migration Inhibitory Factor Deficiency Ameliorates High-Fat Diet Induced Insulin Resistance in Mice with Reduced Adipose Inflammation and Hepatic Steatosis: e113369 by Finucane, Orla M, Reynolds, Clare M, McGillicuddy, Fiona C, Harford, Karen A, Morrison, Martine, Baugh, John, Roche, Helen M

“…Macrophage infiltration is a critical determinant of high-fat diet induced adipose tissue inflammation and insulin resistance. The precise mechanisms…”
Get full text