Search Results - "Finnilä, Mikko A"

Histochemical quantification of collagen content in articular cartilage by Rieppo, Lassi, Janssen, Lauriane, Rahunen, Krista, Lehenkari, Petri, Finnilä, Mikko A J, Saarakkala, Simo

“…Articular cartilage (AC) is mainly composed of water, type II collagen, proteoglycans (PGs) and chondrocytes. The amount of PGs in AC is routinely quantified…”
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Osteogenic Differentiation of Human Mesenchymal Stem cells in a 3D Woven Scaffold by Persson, Maria, Lehenkari, Petri P., Berglin, Lena, Turunen, Sanna, Finnilä, Mikko A. J., Risteli, Juha, Skrifvars, Mikael, Tuukkanen, Juha

“…Fiber-based scaffolds produced by textile manufacturing technology offer versatile materials for tissue engineering applications since a wide range of crucial…”
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Chemical imaging of human teeth by a time-resolved Raman spectrometer based on a CMOS single-photon avalanche diode line sensor by Kekkonen, Jere, Finnilä, Mikko A J, Heikkilä, Jarkko, Anttonen, Vuokko, Nissinen, Ilkka

“…Raman spectroscopy is a powerful analytical tool to be used in many biomedical applications and could be potentially translated into clinical work. The…”
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Association between subchondral bone structure and osteoarthritis histopathological grade by Finnilä, Mikko A. J., Thevenot, Jérôme, Aho, Olli‐Matti, Tiitu, Virpi, Rautiainen, Jari, Kauppinen, Sami, Nieminen, Miika T., Pritzker, Kenneth, Valkealahti, Maarit, Lehenkari, Petri, Saarakkala, Simo

“…ABSTRACT Despite increasing evidence that subchondral bone contributes to osteoarthritis (OA) pathogenesis, little is known about local changes in bone…”
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Micro-computed Tomography-Based Collagen Orientation and Anisotropy Analysis of Rabbit Articular Cartilage by Ojanen, Simo P., Finnilä, Mikko A. J., Herzog, Walter, Saarakkala, Simo, Korhonen, Rami K., Rieppo, Lassi

“…The collagen network is the highly organized backbone of articular cartilage providing tissue tensile stiffness and restricting proteoglycan bleaching out of…”
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Mineralization of dental tissues and caries lesions detailed with Raman microspectroscopic imaging by Das Gupta, Shuvashis, Killenberger, Markus, Tanner, Tarja, Rieppo, Lassi, Saarakkala, Simo, Heikkilä, Jarkko, Anttonen, Vuokko, Finnilä, Mikko A J

“…Dental caries is the most common oral disease that causes demineralization of the enamel and later of the dentin. Depth-wise assessment of the demineralization…”
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Near infrared spectroscopic evaluation of biochemical and crimp properties of knee joint ligaments and patellar tendon by Torniainen, Jari, Ristaniemi, Aapo, Sarin, Jaakko K, Prakash, Mithilesh, Afara, Isaac O, Finnilä, Mikko A J, Stenroth, Lauri, Korhonen, Rami K, Töyräs, Juha

“…Knee ligaments and tendons play an important role in stabilizing and controlling the motions of the knee. Injuries to the ligaments can lead to abnormal…”
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Clinical Super-Resolution Computed Tomography of Bone Microstructure: Application in Musculoskeletal and Dental Imaging by Rytky, Santeri J. O., Tiulpin, Aleksei, Finnilä, Mikko A. J., Karhula, Sakari S., Sipola, Annina, Kurttila, Väinö, Valkealahti, Maarit, Lehenkari, Petri, Joukainen, Antti, Kröger, Heikki, Korhonen, Rami K., Saarakkala, Simo, Niinimäki, Jaakko

“…Purpose Clinical cone-beam computed tomography (CBCT) devices are limited to imaging features of half a millimeter in size and cannot quantify the tissue…”
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Elastic, Viscoelastic and Fibril-Reinforced Poroelastic Material Properties of Healthy and Osteoarthritic Human Tibial Cartilage by Ebrahimi, Mohammadhossein, Ojanen, Simo, Mohammadi, Ali, Finnilä, Mikko A., Joukainen, Antti, Kröger, Heikki, Saarakkala, Simo, Korhonen, Rami K., Tanska, Petri

“…Articular cartilage constituents (collagen, proteoglycans, fluid) are significantly altered during osteoarthritis (OA). A fibril-reinforced poroelastic (FRPE)…”
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Elastic, Dynamic Viscoelastic and Model-Derived Fibril-Reinforced Poroelastic Mechanical Properties of Normal and Osteoarthritic Human Femoral Condyle Cartilage by Ebrahimi, Mohammadhossein, Finnilä, Mikko A. J., Turkiewicz, Aleksandra, Englund, Martin, Saarakkala, Simo, Korhonen, Rami K., Tanska, Petri

“…Osteoarthritis (OA) degrades articular cartilage and weakens its function. Modern fibril-reinforced poroelastic (FRPE) computational models can distinguish the…”
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Structure–Function Relationships of Healthy and Osteoarthritic Human Tibial Cartilage: Experimental and Numerical Investigation by Ebrahimi, Mohammadhossein, Turunen, Mikael J., Finnilä, Mikko A., Joukainen, Antti, Kröger, Heikki, Saarakkala, Simo, Korhonen, Rami K., Tanska, Petri

“…Relationships between composition, structure and constituent-specific functional properties of human articular cartilage at different stages of osteoarthritis…”
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Multiparametric MR imaging reveals early cartilage degeneration at 2 and 8 weeks after ACL transection in a rabbit model by Kajabi, Abdul Wahed, Casula, Victor, Ojanen, Simo, Finnilä, Mikko A., Herzog, Walter, Saarakkala, Simo, Korhonen, Rami K., Nissi, Mikko J., Nieminen, Miika T.

“…In this study, the rabbit model with anterior cruciate ligament transection (ACLT) was used to investigate early degenerative changes in cartilage using…”
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A single intra-articular dose of vitamin D analog calcipotriol alleviates synovitis without adverse effects in rats by Huhtakangas, Johanna A, Huovinen, Jere, Laaksonen, Sakari, Voipio, Hanna-Marja, Vuolteenaho, Olli, Finnilä, Mikko A J, Thevenot, Jérôme, Lehenkari, Petri P

“…1,25-dihydroxyvitamin-D3 and its derivatives have shown anti-arthritic and chondroprotective effects in experimental animal models with prophylactic dosing…”
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Adaptation of Fibril-Reinforced Poroviscoelastic Properties in Rabbit Collateral Ligaments 8 Weeks After Anterior Cruciate Ligament Transection by Orozco, Gustavo A., Ristaniemi, Aapo, Haghighatnejad, Mehrnoush, Mohammadi, Ali, Finnilä, Mikko A. J., Saarakkala, Simo, Herzog, Walter, Isaksson, Hanna, Korhonen, Rami K.

“…Ligaments of the knee provide stability and prevent excessive motions of the joint. Rupture of the anterior cruciate ligament (ACL), a common sports injury,…”
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Osteological profiling of femoral diaphysis and neck in aquatic, semiaquatic, and terrestrial carnivores and rodents: effects of body size and locomotor habits by Nieminen, Petteri, Finnilä, Mikko A. J., Hämäläinen, Wilhelmiina, Lehtiniemi, Saara, Jämsä, Timo, Tuukkanen, Juha, Kunnasranta, Mervi, Henttonen, Heikki, Mustonen, Anne-Mari

“…The increased limb bone density documented previously for aquatic tetrapods has been proposed to be an adaptation to overcome buoyancy during swimming and…”
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Site-specific glycosaminoglycan content is better maintained in the pericellular matrix than the extracellular matrix in early post-traumatic osteoarthritis by Ojanen, Simo P, Finnilä, Mikko A J, Reunamo, Aino E, Ronkainen, Ari P, Mikkonen, Santtu, Herzog, Walter, Saarakkala, Simo, Korhonen, Rami K

“…One of the characteristics of early osteoarthritis (OA) is the loss of fixed charged density (FCD) of glycosaminoglycans in the superficial zone of articular…”
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Age and anatomical region‐related differences in vascularization of the porcine meniscus using microcomputed tomography imaging by Karjalainen, Ville‐Pauli, Herrera Millar, Valentina R., Modina, Silvia, Peretti, Giuseppe M., Pallaoro, Margherita, Elkhouly, Khaled, Saarakkala, Simo, Mobasheri, Ali, Di Giancamillo, Alessia, Finnilä, Mikko A. J.

“…Meniscal lesions in vascularized regions are known to regenerate while lack of vascular supply leads to poor healing. Here, we developed and validated a novel…”
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Lack of collagen XVIII leads to lipodystrophy and perturbs hepatic glucose and lipid homeostasis by Petäistö, Tiina, Vicente, David, Mäkelä, Kari A., Finnilä, Mikko A., Miinalainen, Ilkka, Koivunen, Jarkko, Izzi, Valerio, Aikio, Mari, Karppinen, Sanna‐Maria, Devarajan, Raman, Thevenot, Jerome, Herzig, Karl‐Heinz, Heljasvaara, Ritva, Pihlajaniemi, Taina

“…Key points Extracellular matrix is highly remodelled in obesity and associates with the development of metabolic disorders, such as insulin resistance…”
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Early changes in osteochondral tissues in a rabbit model of post‐traumatic osteoarthritis by Huang, Lingwei, Riihioja, Ilari, Tanska, Petri, Ojanen, Simo, Palosaari, Sanna, Kröger, Heikki, Saarakkala, Simo J., Herzog, Walter, Korhonen, Rami K., Finnilä, Mikko A. J.

“…Concurrent osteoarthritic (OA) manifestations in bone and cartilage are poorly known. To shed light on this issue, this study aims to investigate changes in…”
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Effects of Articular Cartilage Constituents on Phosphotungstic Acid Enhanced Micro-Computed Tomography by Karhula, Sakari S, Finnilä, Mikko A, Lammi, Mikko J, Ylärinne, Janne H, Kauppinen, Sami, Rieppo, Lassi, Pritzker, Kenneth P H, Nieminen, Heikki J, Saarakkala, Simo

“…Contrast-enhanced micro-computed tomography (CEμCT) with phosphotungstic acid (PTA) has shown potential for detecting collagen distribution of articular…”
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