Search Results - "Finnicum, Casey T"

Implementation and implications for polygenic risk scores in healthcare by Slunecka, John L, van der Zee, Matthijs D, Beck, Jeffrey J, Johnson, Brandon N, Finnicum, Casey T, Pool, René, Hottenga, Jouke-Jan, de Geus, Eco J C, Ehli, Erik A

“…Increasing amounts of genetic data have led to the development of polygenic risk scores (PRSs) for a variety of diseases. These scores, built from the summary…”
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Genome-Wide DNA Methylation Profiles in Whole-Blood and Buccal Samples-Cross-Sectional, Longitudinal, and across Platforms by Van Asselt, Austin J, Beck, Jeffrey J, Finnicum, Casey T, Johnson, Brandon N, Kallsen, Noah, Hottenga, Jouke Jan, de Geus, Eco J C, Bios Consortium, Boomsma, Dorret I, Ehli, Erik A, van Dongen, Jenny

“…The field of DNA methylation research is rapidly evolving, focusing on disease and phenotype changes over time using methylation measurements from diverse…”
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Pathogenesis of Tobacco-Associated Lung Adenocarcinoma Is Closely Coupled with Changes in the Gut and Lung Microbiomes by Finnicum, Casey T, Rahal, Zahraa, Hassane, Maya, Treekitkarnmongkol, Warapen, Sinjab, Ansam, Morris, Rhiannon, Liu, Yuejiang, Tang, Elizabeth L, Viet, Sarah, Petersen, Jason L, Lorenzi, Philip L, Tan, Lin, Petrosino, Joseph, Hoffman, Kristi L, Fujimoto, Junya, Moghaddam, Seyed Javad, Kadara, Humam

“…Microbial dysbiosis has emerged as a modulator of oncogenesis and response to therapy, particularly in lung cancer. Here, we investigate the evolution of the…”
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Cohabitation is associated with a greater resemblance in gut microbiota which can impact cardiometabolic and inflammatory risk by Finnicum, Casey T, Beck, Jeffrey J, Dolan, Conor V, Davis, Christel, Willemsen, Gonneke, Ehli, Erik A, Boomsma, Dorret I, Davies, Gareth E, de Geus, Eco J C

“…The gut microbiota composition is known to be influenced by a myriad of factors including the host genetic profile and a number of environmental influences…”
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Relative Telomere Repeat Mass in Buccal and Leukocyte-Derived DNA by Finnicum, Casey T, Dolan, Conor V, Willemsen, Gonneke, Weber, Zachary M, Petersen, Jason L, Beck, Jeffrey J, Codd, Veryan, Boomsma, Dorret I, Davies, Gareth E, Ehli, Erik A

“…Telomere length has garnered interest due to the potential role it may play as a biomarker for the cellular aging process. Telomere measurements obtained from…”
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Epigenetic signatures of asthma: a comprehensive study of DNA methylation and clinical markers by Van Asselt, Austin J, Beck, Jeffrey J, Finnicum, Casey T, Johnson, Brandon N, Kallsen, Noah, Viet, Sarah, Huizenga, Patricia, Ligthart, Lannie, Hottenga, Jouke-Jan, Pool, René, der Zee, Anke H. Maitland-van, Vijverberg, S. J, de Geus, Eco, Boomsma, Dorret I, Ehli, Erik A, van Dongen, Jenny

“…Abstract Background Asthma, a complex respiratory disease, presents with inflammatory symptoms in the lungs, blood, and other tissues. We investigated the…”
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Metataxonomic Analysis of Individuals at BMI Extremes and Monozygotic Twins Discordant for BMI by Finnicum, Casey T., Doornweerd, Stieneke, Dolan, Conor V., Luningham, Justin M., Beck, Jeffrey J., Willemsen, Gonneke, Ehli, Erik A., Boomsma, Dorret I., Ijzerman, Richard G., Davies, Gareth E., de Geus, Eco J. C.

“…Objective: The human gut microbiota has been demonstrated to be associated with a number of host phenotypes, including obesity and a number of…”
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Breast Cancer Polygenic Risk Score Validation and Effects of Variable Imputation by Beck, Jeffrey J, Slunecka, John L, Johnson, Brandon N, Van Asselt, Austin J, Finnicum, Casey T, Ageton, Cheryl, Krie, Amy, Nickles, Heidi, Cowan, Kenneth, Maxwell, Jessica, Boomsma, Dorret I, de Geus, Eco, Ehli, Erik A, Hottenga, Jouke-Jan

“…Breast cancer (BC) is a complex disease affecting one in eight women in the USA. Advances in population genomics have led to the development of polygenic risk…”
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Genetic Ancestry Estimates within Dutch Family Units and Across Genotyping Arrays: Insights from Empirical Analysis Using Two Estimation Methods by Beck, Jeffrey J, Ahmed, Talitha, Finnicum, Casey T, Zwinderman, Koos, Ehli, Erik A, Boomsma, Dorret I, Hottenga, Jouke Jan

“…Accurate inference of genetic ancestry is crucial for population-based association studies, accounting for population heterogeneity and structure. This study…”
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Genetic meta-analysis of twin birth weight shows high genetic correlation with singleton birth weight by Beck, Jeffrey J, Pool, René, van de Weijer, Margot, Chen, Xu, Krapohl, Eva, Gordon, Scott D, Nygaard, Marianne, Debrabant, Birgit, Palviainen, Teemu, van der Zee, Matthijs D, Baselmans, Bart, Finnicum, Casey T, Yi, Lu, Lundström, Sebastian, van Beijsterveldt, Toos, Christiansen, Lene, Heikkilä, Kauko, Kittelsrud, Julie, Loukola, Anu, Ollikainen, Miina, Christensen, Kaare, Martin, Nicholas G, Plomin, Robert, Nivard, Michel, Bartels, Meike, Dolan, Conor, Willemsen, Gonneke, de Geus, Eco, Almqvist, Catarina, Magnusson, Patrik K E, Mbarek, Hamdi, Ehli, Erik A, Boomsma, Dorret I, Hottenga, Jouke-Jan

“…Abstract Birth weight (BW) is an important predictor of newborn survival and health and has associations with many adult health outcomes, including…”
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Genetic Similarity Assessment of Twin-Family Populations by Custom-Designed Genotyping Array by Beck, Jeffrey J., Hottenga, Jouke-Jan, Mbarek, Hamdi, Finnicum, Casey T., Ehli, Erik A., Hur, Yoon-Mi, Martin, Nicholas G., de Geus, Eco J.C., Boomsma, Dorret I., Davies, Gareth E.

“…Twin registries often take part in large collaborative projects and are major contributors to genome-wide association (GWA) meta-analysis studies. In this…”
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The Nigerian Twin and Sibling Registry: An Update by Hur, Yoon-Mi, Jeong, Hoe-Uk, Kang, Man Chull, Ajose, Frances, Kim, Jong Woo, Beck, Jeffrey J, Hottenga, Jouke-Jan, Mbarek, Hamdi, Finnicum, Casey T, Ehli, Erik A, Martin, Nicholas G, de Geus, Eco J, Boomsma, Dorret I, Davies, Gareth E, Bates, Timothy

“…Here we provide an update of the 2013 report on the Nigerian Twin and Sibling Registry (NTSR). The major aim of the NTSR is to understand genetic and…”
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Large-scale association analyses identify host factors influencing human gut microbiome composition by Kurilshikov, Alexander, Medina-Gomez, Carolina, Bacigalupe, Rodrigo, Radjabzadeh, Djawad, Wang, Jun, Demirkan, Ayse, Le Roy, Caroline I., Raygoza Garay, Juan Antonio, Finnicum, Casey T., Liu, Xingrong, Zhernakova, Daria V., Bonder, Marc Jan, Hansen, Tue H., Frost, Fabian, Rühlemann, Malte C., Turpin, Williams, Moon, Jee-Young, Kim, Han-Na, Lüll, Kreete, Barkan, Elad, Shah, Shiraz A., Fornage, Myriam, Szopinska-Tokov, Joanna, Wallen, Zachary D., Borisevich, Dmitrii, Agreus, Lars, Andreasson, Anna, Bang, Corinna, Bedrani, Larbi, Bell, Jordana T., Bisgaard, Hans, Boehnke, Michael, Boomsma, Dorret I., Burk, Robert D., Claringbould, Annique, Croitoru, Kenneth, Davies, Gareth E., van Duijn, Cornelia M., Duijts, Liesbeth, Falony, Gwen, Fu, Jingyuan, van der Graaf, Adriaan, Hansen, Torben, Homuth, Georg, Hughes, David A., Ijzerman, Richard G., Jackson, Matthew A., Jaddoe, Vincent W. V., Joossens, Marie, Jørgensen, Torben, Keszthelyi, Daniel, Knight, Rob, Laakso, Markku, Laudes, Matthias, Launer, Lenore J., Lieb, Wolfgang, Lusis, Aldons J., Masclee, Ad A. M., Moll, Henriette A., Mujagic, Zlatan, Qibin, Qi, Rothschild, Daphna, Shin, Hocheol, Sørensen, Søren J., Steves, Claire J., Thorsen, Jonathan, Timpson, Nicholas J., Vieira-Silva, Sara, Völker, Uwe, Völzke, Henry, Võsa, Urmo, Wade, Kaitlin H., Walter, Susanna, Watanabe, Kyoko, Weiss, Stefan, Weiss, Frank U., Weissbrod, Omer, Westra, Harm-Jan, Willemsen, Gonneke, Payami, Haydeh, Jonkers, Daisy M. A. E., Arias Vasquez, Alejandro, de Geus, Eco J. C., Stokholm, Jakob, Segal, Eran, Kim, Hyung-Lae, Kaplan, Robert C., Spector, Tim D., Uitterlinden, Andre G., Rivadeneira, Fernando, Franke, Andre, Lerch, Markus M., Franke, Lude, Sanna, Serena, D’Amato, Mauro, Pedersen, Oluf, Paterson, Andrew D., Kraaij, Robert, Raes, Jeroen, Zhernakova, Alexandra

“…To study the effect of host genetics on gut microbiome composition, the MiBioGen consortium curated and analyzed genome-wide genotypes and 16S fecal microbiome…”
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Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative by Wang, Jun, Kurilshikov, Alexander, Radjabzadeh, Djawad, Turpin, Williams, Croitoru, Kenneth, Bonder, Marc Jan, Jackson, Matthew A, Medina-Gomez, Carolina, Frost, Fabian, Homuth, Georg, Rühlemann, Malte, Hughes, David, Kim, Han-Na, Spector, Tim D, Bell, Jordana T, Steves, Claire J, Timpson, Nicolas, Franke, Andre, Wijmenga, Cisca, Meyer, Katie, Kacprowski, Tim, Franke, Lude, Paterson, Andrew D, Raes, Jeroen, Kraaij, Robert, Zhernakova, Alexandra

“…In recent years, human microbiota, especially gut microbiota, have emerged as an important yet complex trait influencing human metabolism, immunology, and…”
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Abstract 6204: Differential gut microbiome alpha diversity in endometrial and ovarian carcinoma patients by Finnicum, Casey T., Meissner, Tobias, Davis, Christel, Viet, Sarah, Petersen, Jason L., Deaton, McKenna, Solomon, Benjamin, Spanos, William, Starks, David, Elsey, Rachel, Ehli, Erik A., Williams, Casey

“…Abstract Background: Emerging research underscores the gut microbiome's critical role in cancer development, progression, and response to treatment. As a part…”
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Large-scale association analyses identify host factors influencing human gut microbiome composition by Kurilshikov, Alexander, Medina-Gomez, Carolina, Bacigalupe, Rodrigo, Radjabzadeh, Djawad, Demirkan, Ayse, Le Roy, Caroline I, Garay, Juan Antonio Raygoza, Finnicum, Casey T, Liu, Xingrong, Zhernakova, Daria V, Bonder, Marc Jan, Hansen, Tue H, Frost, Fabian, Rühlemann, Malte C, Turpin, Williams, Moon, Jee-Young, Kim, Han-Na, Lüll, Kreete, Barkan, Elad, nage, Myriam, Szopinska-Tokov, Joanna, Wallen, Zachary D, Borisevich, Dmitrii, Agreus, Lars, Andreasson, Anna, Bang, Corinna, Bedrani, Larbi, Bell, Jordana T, Bisgaard, Hans, Boehnke, Michael, Burk, Robert D, Claringbould, Annique, Croitoru, Kenneth, Davies, Gareth E, van Duijn, Cornelia M, Duijts, Liesbeth, Falony, Gwen, Fu, Jingyuan, van der Graaf, Adriaan, Hansen, Torben, Homuth, Georg, Hughes, David A, Ijzerman, Richard G, Jackson, Matthew A, Jaddoe, Vincent W V, Joossens, Marie, Jørgensen, Torben, Keszthelyi, Daniel, Knight, Rob, Laakso, Markku, Laudes, Matthias, Launer, Lenore J, Lieb, Wolfgang, Lusis, Aldons J, Masclee, Ad A M, Moll, Henriette A, Mujagic, Zlatan, Qibin, Qi, Rothschild, Daphna, Shin, Hocheol, Sørensen, Søren J, Steves, Claire J, Thorsen, Jonathan, Timpson, Nicholas J, Tito, Raul Y, Vieira-Silva, Sara, Völker, Uwe, Võsa, Urmo, Wade, Kaitlin H, Walter, Susanna, Watanabe, Kyoko, Weiss, Stefan, Weiss, Frank U, Weissbrod, Omer, Westra, Harm-Jan, Willemsen, Gonneke, Payami, Haydeh, Jonker, Daisy M A E, Vasquez, Alejandro Arias, de Geus, Eco J C, Meyer, Katie A, Stokholm, Jakob, Segal, Eran, Org, Elin, Wijmenga, Cisca, Kim, Hyung-Lae, Kaplan, Robert C, Spector, Tim D, Uitterlinden, Andre G, Rivadeneira, Fernando, Franke, Andre, Lerch, Markus M, Franke, Lude, Sanna, Serena, D'Amato, Mauro, Pedersen, Oluf, Paterson, Andrew D, Kraaij, Robert, Raes, Jeroen, Zhernakova, Alexandra

“…To study the effect of host genetics on gut microbiome composition, the MiBioGen consortium curated and analyzed genome-wide genotypes and 16S fecal microbiome…”
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Genetically Informative Designs for the Study of Aging and Health Associated Biomarkers by Finnicum, Casey T

“…Genetically informative study designs have long been of great importance for helping to determine the role the environment and genetic susceptibility play in…”
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