Search Results - "Finney, Richard"

CD47-Dependent Regulation of Immune Checkpoint Gene Expression and MYCN mRNA Splicing in Murine CD8 and Jurkat T Cells by Kaur, Sukhbir, Awad, Duha, Finney, Richard P, Meyer, Thomas J, Singh, Satya P, Cam, Margaret C, Karim, Baktiar O, Warner, Andrew C, Roberts, David D

“…Elevated expression of CD47 in some cancers is associated with poor survival related to its function as an innate immune checkpoint when expressed on tumor…”
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Genetic Alterations Activating Kinase and Cytokine Receptor Signaling in High-Risk Acute Lymphoblastic Leukemia by Roberts, Kathryn G., Morin, Ryan D., Zhang, Jinghui, Hirst, Martin, Zhao, Yongjun, Su, Xiaoping, Chen, Shann-Ching, Payne-Turner, Debbie, Churchman, Michelle L., Harvey, Richard C., Chen, Xiang, Kasap, Corynn, Yan, Chunhua, Becksfort, Jared, Finney, Richard P., Teachey, David T., Maude, Shannon L., Tse, Kane, Moore, Richard, Jones, Steven, Mungall, Karen, Birol, Inanc, Edmonson, Michael N., Hu, Ying, Buetow, Kenneth E., Chen, I-Ming, Carroll, William L., Wei, Lei, Ma, Jing, Kleppe, Maria, Levine, Ross L., Garcia-Manero, Guillermo, Larsen, Eric, Shah, Neil P., Devidas, Meenakshi, Reaman, Gregory, Smith, Malcolm, Paugh, Steven W., Evans, William E., Grupp, Stephan A., Jeha, Sima, Pui, Ching-Hon, Gerhard, Daniela S., Downing, James R., Willman, Cheryl L., Loh, Mignon, Hunger, Stephen P., Marra, Marco A., Mullighan, Charles G.

“…Genomic profiling has identified a subtype of high-risk B-progenitor acute lymphoblastic leukemia (B-ALL) with alteration of IKZF1, a gene expression profile…”
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The chromatin remodeling protein Lsh alters nucleosome occupancy at putative enhancers and modulates binding of lineage specific transcription factors by Ren, Jianke, Finney, Richard, Ni, Kai, Cam, Maggie, Muegge, Kathrin

“…Dynamic regulation of chromatin accessibility is a key feature of cellular differentiation during embryogenesis, but the precise factors that control access to…”
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LSH mediates gene repression through macroH2A deposition by Ni, Kai, Ren, Jianke, Xu, Xiaoping, He, Yafeng, Finney, Richard, Braun, Simon M. G., Hathaway, Nathaniel A., Crabtree, Gerald R., Muegge, Kathrin

“…The human Immunodeficiency Centromeric Instability Facial Anomalies (ICF) 4 syndrome is a severe disease with increased mortality caused by mutation in the LSH…”
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Lsh/HELLS is required for B lymphocyte development and immunoglobulin class switch recombination by He, Yafeng, Ren, Jianke, Xu, Xiaoping, Ni, Kai, Schwader, Andrew, Finney, Richard, Wang, Can, Sun, Lei, Klarmann, Kimberly, Keller, Jonathan, Tubbs, Anthony, Nussenzweig, Andre, Muegge, Kathrin

“…Mutation of HELLS (Helicase, Lymphoid-Specific)/Lsh in human DNA causes a severe immunodeficiency syndrome, but the nature of the defect remains unknown. We…”
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The epigenetic regulator LSH maintains fork protection and genomic stability via MacroH2A deposition and RAD51 filament formation by Xu, Xiaoping, Ni, Kai, He, Yafeng, Ren, Jianke, Sun, Chongkui, Liu, Yie, Aladjem, Mirit I., Burkett, Sandra, Finney, Richard, Ding, Xia, Sharan, Shyam K., Muegge, Kathrin

“…The Immunodeficiency Centromeric Instability Facial Anomalies (ICF) 4 syndrome is caused by mutations in LSH/HELLS, a chromatin remodeler promoting…”
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Bambino: a variant detector and alignment viewer for next-generation sequencing data in the SAM/BAM format by EDMONSON, Michael N, JINGHUI ZHANG, CHUNHUA YAN, FINNEY, Richard P, MEERZAMAN, Daoud M, BUETOW, Kenneth H

“…Bambino is a variant detector and graphical alignment viewer for next-generation sequencing data in the SAM/BAM format, which is capable of pooling data from…”
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Genetic variations at loci involved in the immune response are risk factors for hepatocellular carcinoma by Clifford, Robert J., Zhang, Jinghui, Meerzaman, Daoud M., Lyu, Myung‐Soo, Hu, Ying, Cultraro, Constance M., Finney, Richard P., Kelley, Jenny M., Efroni, Sol, Greenblum, Sharon I., Nguyen, Cu V., Rowe, William L., Sharma, Sweta, Wu, Gang, Yan, Chunhua, Zhang, Hongen, Chung, Young‐Hwa, Kim, Jeong A., Park, Neung Hwa, Song, Il Han, Buetow, Kenneth H.

“…Primary liver cancer is the third most common cause of cancer‐related death worldwide, with a rising incidence in Western countries. Little is known about the…”
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Chromatic: WebAssembly-Based Cancer Genome Viewer by Finney, Richard, Meerzaman, Daoud

“…Chromatic is a novel web-browser tool that enables researchers to visually inspect genomic variations identified through next-generation sequencing of cancer…”
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Discovery analysis of TCGA data reveals association between germline genotype and survival in ovarian cancer patients by Braun, Rosemary, Finney, Richard, Yan, Chunhua, Chen, Qing-Rong, Hu, Ying, Edmonson, Michael, Meerzaman, Daoud, Buetow, Kenneth

“…Ovarian cancer remains a significant public health burden, with the highest mortality rate of all the gynecological cancers. This is attributable to the late…”
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Development of a bicistronic anti-CD19/CD20 CAR construct including abrogation of unexpected nucleic acid sequence deletions by Lam, Norris, Finney, Richard, Yang, Shicheng, Choi, Stephanie, Wu, Xiaolin, Cutmore, Lauren, Andrade, Jorge, Huang, Lei, Amatya, Christina, Cam, Margaret, Kochenderfer, James N.

“…To address CD19 loss from lymphoma after anti-CD19 chimeric antigen receptor (CAR) T cell therapy, we designed a bicistronic construct encoding an anti-CD19…”
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Combined immune checkpoint inhibition with durvalumab and tremelimumab with and without radiofrequency ablation in patients with advanced biliary tract carcinoma by Monge, Cecilia, Xie, Changqing, Myojin, Yuta, Coffman‐D'Annibale, Kelley L., Hrones, Donna, Brar, Gagandeep, Wang, Sophie, Budhu, Anuradha, Figg, William D., Cam, Maggie, Finney, Richard, Levy, Elliot B., Kleiner, David E., Steinberg, Seth M., Wang, Xin Wei, Redd, Bernadette, Wood, Bradford J., Greten, Tim F.

“…Background Current standard of care for advanced biliary tract cancer (BTC) is gemcitabine, cisplatin plus anti‐PD1/PD‐L1, but response rates are modest. The…”
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Genomic Heterogeneity Within Individual Prostate Cancer Foci Impacts Predictive Biomarkers of Targeted Therapy by VanderWeele, David J., Finney, Richard, Katayama, Kotoe, Gillard, Marc, Paner, Gladell, Imoto, Seiya, Yamaguchi, Rui, Wheeler, David, Lack, Justin, Cam, Maggie, Pontier, Andrea, Nguyen, Yen Thi Minh, Maejima, Kazuhiro, Sasaki-Oku, Aya, Nakano, Kaoru, Tanaka, Hiroko, Vander Griend, Donald, Kubo, Michiaki, Ratain, Mark J., Miyano, Satoru, Nakagawa, Hidewaki

“…Most lethal prostate cancers progress from relapse of aggressive primary disease. Recently, the most significant advances in survival benefit from systemic…”
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Systematic analysis of genetic alterations in tumors using Cancer Genome WorkBench (CGWB) by Zhang, Jinghui, Finney, Richard P, Rowe, William, Edmonson, Michael, Yang, Sei Hoon, Dracheva, Tatiana, Jen, Jin, Struewing, Jeffery P, Buetow, Kenneth H

“…Systematic investigations of genetic changes in tumors are expected to lead to greatly improved understanding of cancer etiology. To meet the analytical…”
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Detecting false expression signals in high-density oligonucleotide arrays by an in silico approach by Zhang, Jinghui, Finney, Richard P., Clifford, Robert J., Derr, Leslie K., Buetow, Kenneth H.

“…High-density oligonucleotide arrays have become a popular assay for concurrent measurement of mRNA expression at the genome scale. Much effort has been devoted…”
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Alview: Portable Software for Viewing Sequence Reads in BAM Formatted Files by Finney, Richard P., Chen, Qing-Rong, Nguyen, Cu V., Hsu, Chih Hao, Yan, Chunhua, Hu, Ying, Abawi, Massih, Bian, Xiaopeng, Meerzaman, Daoud M.

“…The name Alview is a contraction of the term Alignment Viewer. Alview is a compiled to native architecture software tool for visualizing the alignment of…”
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Genome-wide transcriptional sequencing identifies novel mutations in metabolic genes in human hepatocellular carcinoma by Meerzaman, Daoud M, Yan, Chunhua, Chen, Qing-Rong, Edmonson, Michael N, Schaefer, Carl F, Clifford, Robert J, Dunn, Barbara K, Dong, Li, Finney, Richard P, Cultraro, Constance M, Hu, Ying, Yang, Zhihui, Nguyen, Cu V, Kelley, Jenny M, Cai, Shuang, Zhang, Hongen, Zhang, Jinghui, Wilson, Rebecca, Messmer, Lauren, Chung, Young-Hwa, Kim, Jeong A, Park, Neung Hwa, Lyu, Myung-Soo, Song, Il Han, Komatsoulis, George, Buetow, Kenneth H

“…We report on next-generation transcriptome sequencing results of three human hepatocellular carcinoma tumor/tumor-adjacent pairs. This analysis robustly…”
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A high-resolution multistrain haplotype analysis of laboratory mouse genome reveals three distinctive genetic variation patterns by Zhang, Jinghui, Hunter, Kent W, Gandolph, Michael, Rowe, William L, Finney, Richard P, Kelley, Jenny M, Edmonson, Michael, Buetow, Kenneth H

“…Understanding of the structure and the origin of genetic variation patterns in the laboratory inbred mouse provides insight into the utility of the mouse model…”
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Development of a Bicistronic Anti-CD19/CD20 CAR Construct Including Optimization to Abrogate Retroviral Recombination Events by Lam, Norris, Choi, Stephanie, Yang, Shicheng, Finney, Richard, Cam, Margaret, Wu, Xiaolin, Kochenderfer, James N.

“…Anti-CD19 chimeric antigen receptor (CAR) T cells can eliminate lymphoma, but CD19 loss from lymphoma can cause anti-CD19 CAR T-cell treatment failure. To…”
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Transcriptional alterations in hereditary and sporadic nonfunctioning pancreatic neuroendocrine tumors according to genotype by Keutgen, Xavier M., Kumar, Suresh, Gara, Sudheer, Boufraqech, Myriem, Agarwal, Sunita, Hruban, Ralph H., Nilubol, Naris, Quezado, Martha, Finney, Richard, Cam, Maggie, Kebebew, Electron

“…BACKGROUND Nonfunctioning pancreatic neuroendocrine tumors (NFPanNETs) may be sporadic or inherited because of germline mutations associated with von…”
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